8-Bromo-cAMP-sodium-salt-8-Br-Camp-sodium-salt-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE8-Bromo-cAMP sodium saltCat. No.: HY-12306CAS No.: 76939-46-3Synonyms: 8-Br-Camp sodium salt分式: CHBrNNaOP分量: 430.08作靶点: PKA作通路: Protein Tyrosine Kinase/RTK; Stem Cell/Wnt储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months

2、-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (290.64 mM; Need ultrasonic)H2O : 33.33 mg/mL (77.50 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3251 mL 11.6257 mL 23.2515 mL5 mM 0.4650 mL 2.3251 mL 4.6503 mL10 mM 0.2325 mL 1.1626 mL 2.3251 mL请根据产品在不同溶剂中的溶解

3、度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.84 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD

4、in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (4.84 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.84 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt)种环 AMP 类似物， 种环 AMP 依赖性蛋激酶(PKA) 激活剂 1。IC

5、50 & Target PKA 1体外研究 8-Bromo-cAMP sodium salt is a brominated derivative of cyclic AMP. 8-Bromo-cAMP sodium salt enhancesthe efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiencyof human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium sa

6、lt inhibits proliferation, inducedifferentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109) 1.REFERENCES1. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011Jun;7(2):331-41.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4