Astragalin-Astragaline-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAstragalinCat. No.: HY-N0015CAS No.: 480-10-4Synonyms: Astragaline; 3-Glucosylkaempferol; Kaempferol 3-D-glucopyranoside分式: CHO分量: 448.38作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性数据体外实验 DMSO : 100 mg/mL (223.03 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2303 mL 11.1513 mL 22.3025 mL5 mM 0.4461 mL 2.2303 mL 4.4605 mL10 mM 0.2230 mL 1.1151 mL 2.2303 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，

3、配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.58 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChe

4、mESolubility: 2.5 mg/mL (5.58 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.58 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 紫云英苷（奈酚-3-O-葡萄糖苷）种黄酮类化合物，具有抗炎活性。REFERENCES1. Cho IH, et al. Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modula

5、ting oxidative stress-responsiveMAPK signaling. BMC Pulm Med. 2014 Jul 29;14:122.2. Li F, et al. Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells. JSurg Res. 2014 Dec;192(2):573-81.3. Li F, et al. Astragalin suppresses inflammator

6、y responses via down-regulation of NF-B signaling pathway in lipopolysaccharide-inducedmastitis in a murine model. Int Immunopharmacol. 2013 Oct;17(2):478-82.4. Kim MS, et al. Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-B inmacrophage

7、s. Arch Pharm Res. 2011 Dec;34(12):2101-7.5. Soromou LW, et al. Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-B signalingpathway. Biochem Biophys Res Commun. 2012 Mar 9;419(2):256-61.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use