THZ1-R - CDK 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETHZ1-RCat. No.: HY-19988CAS No.: 1621523-07-6分式: CHClNO分量: 568.07作靶点: CDK作通路: Cell Cycle/DNA Damage储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (176.03 mM)H2O : 40% PEG300 5% T

2、ween-80 45% salineSolubility: 2.5 mg/mL (4.40 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.40 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 THZ1-RTHZ1的半胱氨酸反应性类似物，对 CDK7 抑制的活性降低。 THZ1-R与 CDK7 结合的 Kd 为142nM。IC50 & Target CD

3、K7146 nM (IC50)体外研究 THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM 1.PROTOCOLCell Assay 1 Cells are seeded in 384-well microplates at 15% confluency in medium with 5% FBS andpenicillin/streptavidin. Cells are treated with THZ1 or DMSO for 72 hrs and cell viability is determined u

4、singresazurin.MCE has not independently confirmed the accuracy of these methods. They are for reference only.户使本产品发表的科研献 Proc Natl Acad Sci U S A. 2019 Jun 10. Cell Death Dis. 2019 Aug 9;10(8):602.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;