MGCD-265-analog-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMGCD-265 analogCat. No.: HY-10991CAS No.: 875337-44-3分式: CHFNOS分量: 517.6作靶点: c-Met/HGFR; VEGFR作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (193.

2、20 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9320 mL 9.6600 mL 19.3199 mL5 mM 0.3864 mL 1.9320 mL 3.8640 mL10 mM 0.1932 mL 0.9660 mL 1.9320 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性

3、，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (5.31 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (5.31 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn

4、oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.75 mg/mL (5.31 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 MGCD265-analog结构上与MGCD-265相似, MGCD265-analog种有效的多靶点酪氨酸激酶抑制剂,作于c-Met, VEGFR2， IC50值分别为29 nM和10 nM。IC50 & Target VEGFR2 c-Met10 nM (IC50) 29 nM (IC50)户使本产品发表的科研献 Harvard Medical S

5、chool LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Claridge S, et al. Discovery of a novel and potent series of thieno3,2-bpyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-