EP1013-F1013-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEP1013Cat. No.: HY-10397CAS No.: 223568-55-6Synonyms: F1013分式: CHFNO分量: 382.38作靶点: Caspase作通路: Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 60 mg/mL (156.91 mM)* means soluble,

2、but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6152 mL 13.0760 mL 26.1520 mL5 mM 0.5230 mL 2.6152 mL 5.2304 mL10 mM 0.2615 mL 1.3076 mL 2.6152 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 EP1013种谱的 caspase 选择性抑制剂，可于 1 型糖尿病研究。IC50 & Target Caspase体

3、内研究EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEEP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group isnot significantly different from

4、the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function 1.REFERENCES1. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islettransplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F