ML367 _ATAD5 Stabilization 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEML367Cat. No.: HY-122198CAS No.: 381168-77-0分式: CHFN分量: 334.32作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (373.89 mM)* means soluble, but saturation unkn

2、own.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9911 mL 14.9557 mL 29.9115 mL5 mM 0.5982 mL 2.9911 mL 5.9823 mL10 mM 0.2991 mL 1.4956 mL 2.9911 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以

3、下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.22 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.22 mM); Suspended solution; Need ultrasonic3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Sma

4、ll Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (6.22 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 ML367种 ATPase 家族 AAA 结构域蛋 5 (ATAD5) 稳定的有效抑制剂，作为个探针分，具有低摩尔抑制浓度。ML367 阻断 DNA 的修复通路，抑制般的 DNA 损伤反应，包括应对紫外照射产的 RPA32 和CHK1 的磷酸化 1。IC50 & Target ATAD5 1体外研究 ML367 (0-40 M, 16 hours) inhibits FLAG-ATAD5 s

5、tabilization in HEK293T cells in the presence or absenceof 20 M 5-FUrd 1.Western Blot Analysis 1Cell Line: HEK293T cellsConcentration: 0-40 M in the presence or absence of 20 M 5-FurdIncubation Time: 16 hoursResult: Inhibited the increased ATAD5 protein levels induced by 5-Furd.REFERENCES1. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379