PF-4840154 _TRP Channel Agonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPF-4840154Cat. No.: HY-18779CAS No.: 1332708-14-1分式: CHNO分量: 466.62作靶点: TRP Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 5

2、0 mg/mL (107.15 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1431 mL 10.7154 mL 21.4307 mL5 mM 0.4286 mL 2.1431 mL 4.2861 mL10 mM 0.2143 mL 1.0715 mL 2.1431 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液

3、，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.36 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.36 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubil

4、ity: 2.5 mg/mL (5.36 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 PF-4840154有效，选择性的和 TrpA1 通道激动剂， EC50分别为97和23nM。IC50 & Target IC50: 97 nM (rTrpA1), 23 nM (hTrpA1) 1REFERENCES1. Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;