MK-6240-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMK-6240Cat. No.: HY-101186CAS No.: 1841078-87-2分式: CHFN分量: 278.28作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 12.5 mg/mL (44.92 mM; Need ultrasonic)Mass Solvent1 mg

2、 5 mg 10 mg Concentration制备储备液1 mM 3.5935 mL 17.9675 mL 35.9350 mL5 mM 0.7187 mL 3.5935 mL 7.1870 mL10 mM 0.3594 mL 1.7968 mL 3.5935 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液

3、中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.25 mg/mL (4.49 mM); Suspended solution; Need ultrasonicBIOLOGICAL ACTIVITY物活性MK-6240 种针对 神经纤维缠结 (NFTs) 的正电发射断层显像 (PET) 踪剂，对 NFT 的结合具有较的特1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE异性和选择性。IC50 & Target Ki: NFT 1.REFEREN

4、CES1. Walji AM, et al. Discovery of 6-(Fluoro-(18)F)-3- (1H-pyrrolo 2,3-cpyridin-1-yl) isoquinolin-5-amine (18)F-MK-6240): A PositronEmission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02