MB05032-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMB05032Cat. No.: HY-16307CAS No.: 261365-11-1分式: CHNOPS分量: 302.29作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (165.40 mM; Need ultrasonic)Mass Solvent1 mg

2、5 mg 10 mg Concentration制备储备液1 mM 3.3081 mL 16.5404 mL 33.0808 mL5 mM 0.6616 mL 3.3081 mL 6.6162 mL10 mM 0.3308 mL 1.6540 mL 3.3081 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中

3、的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.27 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.27 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.27 mM); Clear solution1/2 Master of

4、 Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 MB05032是GNG 抑制剂，能靶向果糖-1，6-双磷酸酯酶的AMP结合位点，IC50为 16 nM。IC50 & Target IC50: 16 nM (Human Liver FBPase) 1体内研究 MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZD

5、F rats with mild diabetes and aged ZDF rats with overt diabetes 1.Animal Model: ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes) 1Dosage: 3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats)Administration: Oral administration; onceResult: R

6、esults in dose-dependent glucose lowering.户使本产品发表的科研献 Nat Med. 2018 Sep;24(9):1395-1406. Cell Metab. 2018 Aug 7;28(2):243-255.e5.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase fo

7、r controlling gluconeogenesis intype 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.2. Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.Endocrinology. 2010 Oct;151(10):4688-95.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use