Diosgenin _STAT 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDiosgeninCat. No.: HY-N0177CAS No.: 512-04-9分式: CHO分量: 414.62作靶点: STAT作通路: JAK/STAT Signaling; Stem Cell/Wnt储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 Ethanol : 6.67 mg/mL (16.09 mM; Need ult

2、rasonic)DMSO : 40% PEG300 5% Tween-80 45% salineSolubility: 0.67 mg/mL (1.62 mM); Clear solution2. 请依序添加每种溶剂： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 0.67 mg/mL (1.62 mM); Clear solution3. 请依序添加每种溶剂： 10% EtOH 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 0.67 mg/mL

3、(1.62 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Diosgenin，种甾体皂苷，能够抑制 STAT3 信号通路。Diosgenin是Pdia3/ERp57 的激活剂 4。IC50 & Target STAT3体外研究 In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 M, may represent agood candidate as a steroidal moiety in our bivalent compounds

4、 against AD pathology 1. Diosgenin inhibitsthe constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibitionoccurring at around 100 M 2.体内研究 Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenintreatment signi

5、ficantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice 3.户使本产品发表的科研献 Cell Physiol Biochem. 2016;39(4):1626-37.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin as

6、multifunctional compounds against Alzheimersdisease. Bioorganic & Medicinal Chemistry, 23 (2015) 732473312. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation andchemosensitization of human hepatocellular carcinoma cells. Cancer Lett

7、. 2010 Jun 28;292(2):197-207.3. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ER in the regulation of PPAR. Toxicol Appl Pharmacol. 2015 Dec1;289(2):286-96.4. Tohda C, et al. Diosgenin is an exogenous activator of 1,25D-MARRS/Pdia3/ERp57 and improves Alzheimers disease pathologies in 5XFADmice. Sci Rep. 2012;2:535.McePdfHeightCaution: Product has not been fully validated for medical applications.For research