Cinchonidine-α-Quinidine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECinchonidineCat. No.: HY-N0173CAS No.: 485-71-2Synonyms: -Quinidine分式: CHNO分量: 294.39作靶点: Serotonin Transporter作通路: Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 33.33 m

2、g/mL (113.22 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3969 mL 16.9843 mL 33.9685 mL5 mM 0.6794 mL 3.3969 mL 6.7937 mL10 mM 0.3397 mL 1.6984 mL 3.3969 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您

3、现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.49 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.49 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master

4、of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (8.49 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Cinchonidine (-Quinidine)在鸡纳和蒿中发现的鸡纳物碱。 Cinchonidine (-Quinidine) 于有机化学中不对称合成的砌块。 素转运蛋 (SERT)的弱抑制剂，对于dSERT，hSERT，hSERTI172M，hSERT S438T，hSERT Y95F的 Ki 分别为330，4.2，36，196，15 M。有抗疟活性 1.。IC50 & Ta

5、rget Ki: 330 M (dSERT), 4.2 M (hSERT), 36 M (hSERT I172M), 196 M (hSERT S438T), 15 M (hSERTY95F) 1体外研究 Cinchonidine (-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Abuilding block used in asymmetric synthesis in organic chemistry. Weak inhibitor of seroto

6、nin transporter(SERT) with Kis of 330, 4.2, 36, 196, 15 M for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERTY95F, respectively 1.REFERENCES1. Beckman ML, et al. Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochem Int. 2014 Jul;73:98-106.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400