Telratolimod-MEDI-9197-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETelratolimodCat. No.: HY-109104CAS No.: 1359993-59-1Synonyms: MEDI 9197; 3M 052分式: CHNO分量: 593.89作靶点: Toll-like Receptor (TLR)作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数

2、据体外实验 DMSO : 5 mg/mL (8.42 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 0.5 mg/mL (0.84 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 0.5 mg/mL (0.84 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3

3、. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 0.5 mg/mL (0.84 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Telratolimod种 TLR7/8 激动剂，具有抗肿瘤活性。IC50 & Target TLR7/8 1体外研究 Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity 1.体内研究 Telratolimod (50 g) inhibits the tum

4、or volume, and more potently blocks tumor gowth in combination withCpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 g) plus 200 g of CpGODN slows tumor growth and prolongs survival of mice bearing large tumors 1.REFERENCES1. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer.2014 May 13;2:12.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;