MMV008138 _Parasite 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMMV008138Cat. No.: HY-123561CAS No.: 1679333-73-3分式: CHClNO分量: 361.22作靶点: Parasite作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (346.05 mM; Need ultrasonic)Ma

2、ss Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7684 mL 13.8420 mL 27.6840 mL5 mM 0.5537 mL 2.7684 mL 5.5368 mL10 mM 0.2768 mL 1.3842 mL 2.7684 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的

3、百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.76 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.76 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 MMV008

4、138种物种选择性抗疟剂，靶向 MEP 途径中的 IspD 酶，对恶性疟原 Dd2 株作的 IC50 值为 250 nM 1 2。IC50 & Target IC50: 250 nM (P. falciparum Dd2 strain) 1REFERENCES1. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3

5、S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559.2. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initialstructure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-