Embelin-Embelic-acid-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEmbelinCat. No.: HY-17473CAS No.: 550-24-3Synonyms: Embelic acid; Emberine; NSC 91874分式: CHO分量: 294.39作靶点: IAP作通路: Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (169.84

2、mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3969 mL 16.9843 mL 33.9685 mL5 mM 0.6794 mL 3.3969 mL 6.7937 mL10 mM 0.3397 mL 1.6984 mL 3.3969 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，

3、体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.49 mM); Suspended solution; Need ultrasonic2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.49 mM); Clear solution1/2 Master of Small Molecule

4、s 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Embelin可渗透细胞的，有抗癌特性的苯醌化合物。户使本产品发表的科研献 Mol Neurobiol. 2014 Apr;49(2):1087-101.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Siegel C, et al. miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences

5、in the response to cerebralischemia. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.2. Hu R, et al. Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. Med Oncol. 2011 Dec;28(4):1584-8.3. Siegelin MD, et al. The XIAP inhibitor Embelin enhances TRAIL-mediated apo

6、ptosis in malignant glioma cells by down-regulation of theshort isoform of FLIP. Neurochem Int. 2009 Nov;55(6):423-30.4. Kalyan Kumar G, et al. Embelin reduces cutaneous TNF- level and ameliorates skin edema in acute and chronic model of skininflammation in mice. Eur J Pharmacol. 2011 Jul 15;662(1-3

7、):63-9.5. Kumar G K, et al. Embelin ameliorates dextran sodium sulfate-induced colitis in mice. Int Immunopharmacol. 2011 Jun;11(6):724-31.6. Xue Z, et al. Embelin suppresses dendritic cell functions and limits autoimmune encephalomyelitis through the TGF-/-catenin andSTAT3 signaling pathways. Mol Neurobiol. 2014 Apr;49(2):1087-101.McePdfHeightCaution: Product has not been fully validated for medical applications.For research