氯前列烯醇纳作用机制 - Medchemexpress - MCE中国

1、Product Data SheetCloprostenol sodium saltCat. No.: HY-108415CAS No.: 55028-72-3分式: CHClNaO分量: 446.9作靶点: Prostaglandin Receptor作通路: GPCR/G Protein储存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 months; -20C, 1 month (sealed storage, away frommoisture)溶解性数据体外实验 H2O : 150 mg/mL (335.

2、65 mM)* means soluble, but saturation unknown.SolventMass1 mg 5 mg 10 mgConcentration制备储备液1 mM 2.2376 mL 11.1882 mL 22.3764 mL5 mM 0.4475 mL 2.2376 mL 4.4753 mL10 mM 0.2238 mL 1.1188 mL 2.2376 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存式和期限：-80C, 6 months; -20C, 1 month (sealed st

3、orage, away from moisture)。-80C 储存时，请在 6 个内使，-20C 储存时，请在 1 个内使。BIOLOGICAL ACTIVITY物活性 Cloprostenol sodium salt (ICI 80996 sodium salt) PGF2 receptor 的激动剂2。种合成的、有效的前列腺素类似物，具有黄体溶解性1，为IC & Target PGF2 receptor2体外研究 Cloprostenol is a PGF2 receptor agonist2.Cloprostenol (0.1 M) counteracts the adipogenic

4、 effects of statil, on both intracellular lipid accumulation andexpression of transcripts for proadipogenic factors C/EBP and PPAR after treatment for 6 days2.体内研究 Cloprostenol sodium salt (25 g) decreases plasma progesterone in pregnant rats1.Page 1 of 2 www.MedChemEREFERENCES1. Salazar H, et al. L

5、uteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. BiolReprod. 1976 May;14(4):458-72.2. Pastel E, et al. Aldose reductases influence prostaglandin F2 levels and adipocyte differentiation in male mouse and human species. Endocrinology.2015 May;156(5):1671-84.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792;Fax: 02