SARS-CoV-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html SARS-CoVSARS coronavirusSARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). CoVs are enveloped viruses with apositive-sense, single-stranded RNA and can cause health-threatening outbreaks by targeting human resp

2、iratory system, includingnot only SARS, but also Middle East respiratory syndrome (MERS) and SARS-CoV-2 (the cause of COVID-19).CoVs have four main structural proteins: spike(S), membrane (M), envelope (E), and nucleocapsid (N) proteins. An S proteinmediates the CoV entry into host cells by attachin

3、g to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 forMERS-CoV), followed by fusion between virus and host cell membranes. Genome replication and subgenomic RNA transcriptionafter entry carry on with the participation of many nonstructural proteins such as Mpro (main protease or 3CLpro

4、), PLpro(papain-like protease) and RdRp (RNA-dependent RNA polymerase). Then the structural proteins are translated, assembled intomature virions, and released via vesicles by exocytosis. It is worth mentioning that a protease called TMPRSS2 (transmembraneprotease, serine 2) play important roles thr

5、oughout the whole life of CoVs (such as attachment, assembling and release) by cleavingS protein. All the proteins and subcellular structures participated in the life cycle of CoVs are promising targets for treatment ofdisease caused by CoVs.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/SARS-

6、CoV.html SARS-CoV HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html Modulators HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html

7、 HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html & HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html HYPERLINK https:/www.MedChemE/Targets/SARS-CoV.html Chemicals HYPERLINK https:/www.MedChemE/r-hydroxychloroquine.html (R)-Hydroxychloroquine(R)-HCQ) Cat. No.: HY-B1370B HYPERLINK https:/www.Med

8、ChemE/rac-x77.html (Rac)-X77Cat. No.: HY-136298(R)-Hydroxychloroquine is the enantiomer ofHydroxychloroquine. Hydroxychloroquine is asynthetic antimalarial drug which can also inhibitToll-like receptor 7/9 (TLR7/9) signaling.Hydroxychloroquine is efficiently inhibitsSARS-CoV-2 infection in vitro.(Ra

9、c)-X77 is a racemate of X77. X77 is apotent non-covalent inhibitor of the main proteaseof SARS-CoV-2 (SARS-CoV-2 Mpro). X77 binds toSARS-CoV-2 Mpro with a K value of 0.057 M.dPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mgPurity: 99.65%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 m

10、g, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/s-hydroxychloroquine.html (S)-Hydroxychloroquine(S)-HCQ) Cat. No.: HY-B1370A HYPERLINK https:/www.MedChemE/racemic-alliin.html ()-Alliin()-L-Alliin) Cat. No.: HY-126085(S)-Hydroxychloroquine (S)-HCQ) is the enantiomerof Hydroxychloroquine. Hydroxychloro

11、quine, asynthetic antimalarial drug, inhibits Toll-likereceptor 7/9 (TLR7/9) signaling, and showsefficiently inhibits SARS-CoV-2 infection invitro.()-Alliin is the main active component of garlic.()-Alliin is a putative inhibitor of the mainprotease of SARS-CoV-2 (M ).proPurity: 98%Clinical Data: La

12、unchedSize: 1 mg, 5 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/2-hydroxyacetophenone.html 2-Hydroxyacetophenone HYPERLINK https:/www.MedChemE/2-hydroxyacetophenone.html HYPERLINK https:/www.MedChemE/2-hydroxycinnamic-acid.html 2-Hydroxycinnam

13、ic HYPERLINK https:/www.MedChemE/2-hydroxycinnamic-acid.html HYPERLINK https:/www.MedChemE/2-hydroxycinnamic-acid.html acidCat. No.: HY-W002198 Cat. No.: HY-W0125312-Hydroxyacetophenone is a principal root volatileof the Carissa edulis. 2-Hydroxyacetophenone showsinhibitory effects on infection of H

14、IV/SARS-CoV Spseudovirus with an IC of 1.8 mM.502-Hydroxycinnamic acid is isolated from themethanol extract of Cinnamomum cassia.2-Hydroxycinnamic acid shows inhibitory effects oninfection of HIV/SARS-CoV S pseudovirus with an ICof 0.3 mM.50Purity: 99.74%Clinical Data: No Development ReportedSize: 1

15、0 mM 1 mL,Purity: 97.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mg HYPERLINK https:/www.MedChemE/3cplro-in-1.html 3CPLro-IN-1 HYPERLINK https:/www.MedChemE/3cplro-in-1.html HYPERLINK https:/www.MedChemE/3cplro-in-2.html 3CPLro-IN-2Cat. No.: HY-144260 Cat. No.: HY-1442633CPLro-IN-1

16、 (compound A17) is a potent and orallyactive inhibitor of SARS-CoV-2 3CLpro with anIC of 5.65 M. 3-Chymotrypsin-like cysteine50protease (3CLpro) is an indispensable protein inviral replication and represents an attractivedrug target for fighting COVID-19.3CPLro-IN-2 (compound C1) is a potent and ora

17、llyactive inhibitor of SARS-CoV-2 3CLpro with anIC50 and Ki of 1.55 and 6.09 M, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/4-o-methylbavachalcone.html 4-O-Methylbavachal

18、cone HYPERLINK https:/www.MedChemE/4-o-methylbavachalcone.html HYPERLINK https:/www.MedChemE/6-Thioguanine.html 6-ThioguanineCat. No.: HY-N1910(Thioguanine; 2-Amino-6-purinethiol) Cat. No.: HY-137654-O-Methylbavachalcone is a chalcone isolatedfrom Psoralea corylifolia, inhibits severe acuterespirato

19、ry syndrome coronavirus (SARS-CoV)papain-like protease (PLpro) activity, with anIC of 10.1 M.506-Thioguanine (Thioguanine; 2-Amino-6-purinethiol)is an anti-leukemia and immunosuppressant agent,acts as an inhibitor of SARS and MERS coronaviruspapain-like proteases (PLpros) and also potentlyinhibits U

20、SP2 activity, with IC s of 25 M and5040 M for Plpros and recombinant humanPurity: 99.85%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/

21、acriflavine-hydrochloride.html Acriflavine HYPERLINK https:/www.MedChemE/acriflavine-hydrochloride.html HYPERLINK https:/www.MedChemE/acriflavine-hydrochloride.html hydrochloride(Acriflavinium chloride hydrochloride) Cat. No.: HY-W088075 HYPERLINK https:/www.MedChemE/alc-0315.html ALC-0315Cat. No.:

22、HY-138170Acriflavine hydrochloride (Acriflavinium chloridehydrochloride) is a fluorescent acridine dye thatcan be used to label nucleic acid. Acriflavinehydrochloride is an antiseptic. Acriflavinehydrochloride is a potent HIF-1 inhibitor, withantitumor activity.ALC-0315 is an ionisable aminolipid th

23、at isresponsible for mRNA compaction and aids mRNAcellular delivery and its cytoplasmic releasethrough suspected endosomal destabilization.ALC-0315 can be used to form lipid nanoparticle(LNP) delivery vehicles.Purity: 97.0%Clinical Data: No Development ReportedSize: 500 mgPurity: 98.0%Clinical Data:

24、 No Development ReportedSize: 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Aloxistatin.html Aloxistatin(E64d; E64c ethyl ester) Cat. No.: HY-100229 HYPERLINK https:/www.MedChemE/Amprenavir.html Amprenavir(VX-478) Cat. No.: HY-17430Aloxistatin (E64d) is a cell-permeable andirreversible broad-sp

25、ectrum cysteine proteaseinhibitor. Aloxistatin (E64d) exhibitsentry-blocking effect for MERS-CoV.Amprenavir (VX-478) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.Amprenavir is also a SARS-CoV 3CLpro inhibitorwith an IC of 1.09 M.50Purity: 99.55%Clinical Data: No Development Rep

26、ortedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.58%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 25 mg, 50 mg HYPERLINK https:/www.MedChemE/amprenavir-d4.html Amprenavir-d4Cat. No.: HY-17430S HYPERLINK https:/www.MedChemE/amprenavir-d4-1.html Amprenavir-d4-1(VX-478-d4-1) Cat. No.

27、: HY-17430S1Amprenavir-d4 is the deuterium labeled Amprenavir.Amprenavir (VX-478) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.Amprenavir is also a SARS-CoV 3CLpro inhibitorwith an IC of 1.09 M.50Amprenavir-d4-1 is deuterium labeled Amprenavir.Amprenavir (VX-478) is a HIV prote

28、ase inhibitor(Ki=0.6 nM) used to treat HIV infection.Amprenavir is also a SARS-CoV 3CLpro inhibitorwith an IC50 of 1.09 M.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mgPurity: 98%Clinical Data:Size: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/amy-101.html AMY-101 HYPERLINK https:/ww

29、w.MedChemE/amy-101.html HYPERLINK https:/www.MedChemE/amy-101-acetate.html AMY-101 HYPERLINK https:/www.MedChemE/amy-101-acetate.html HYPERLINK https:/www.MedChemE/amy-101-acetate.html acetate(Cp40) Cat. No.: HY-P1717 (Cp40 acetate) Cat. No.: HY-P1717BAMY-101 (Cp40), a peptidic inhibitor of thecentr

30、al complement component C3 (K = 0.5DnM), inhibits naturally occurring periodontitis innon-human primates (NHPs).AMY-101 acetate (Cp40 acetate), a peptidicinhibitor of the central complement componentC3 (K = 0.5 nM), inhibits naturally occurringDperiodontitis in non-human primates (NHPs).Purity: 98%C

31、linical Data: Phase 2Size: 1 mg, 5 mg, 10 mgPurity: 99.93%Clinical Data: Phase 2Size: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/amy-101-tfa.html AMY-101 HYPERLINK https:/www.MedChemE/amy-101-tfa.html HYPERLINK https:/www.MedChemE/amy-101-tfa.html TFA HYPERLINK https:/www.MedChemE/amy-101-tfa.h

32、tml HYPERLINK https:/www.MedChemE/andrographolide.html Andrographolide(Cp40 TFA) Cat. No.: HY-P1717A (Andrographis) Cat. No.: HY-N0191AMY-101 TFA (Cp40 TFA), a peptidic inhibitor ofthe central complement component C3 (K =D0.5 nM), inhibits naturally occurringperiodontitis in non-human primates (NHPs

33、).Andrographolide is a NF-B inhibitor, whichinhibits NF-B activation through covalentmodification of a cysteine residue on p50 inendothelial cells without affecting IBdegradation or p50/p65 nuclear translocation.Andrographolide has antiviral effects.Purity: 99.94%Clinical Data: Phase 2Size: 1 mg, 5

34、mg, 10 mgPurity: 98.57%Clinical Data: LaunchedSize: 100 mg, 500 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/ansabananin.html AnsabananinCat. No.: HY-145116 HYPERLINK https:/www.MedChemE/anti-mers-2e6-mab.html Anti-MERS-2E6 HYPERLINK https:/www.MedChemE/anti-mers-2e6-mab.html HYPERLINK https:/www.

35、MedChemE/anti-mers-2e6-mab.html mAb(MERS-2E6; MERS Antibody-2E6) Cat. No.: HY-P9804Ansabananin is a weak inhibitor of the ATPaseactivity of the SARS Coronavirus helicase with anIC value of 51 M.50Anti-MERS-2E6 mAb (MERS-2E6; MERS Antibody-2E6), ahuman neutralizing antibody IgG1 (CHO expressed)that c

36、an compete for the binding of the virusSpike protein to the receptor (CD26), therebyinhibiting virus invasion into host cells.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 100 g, 500 g HYPERLINK https:/www.MedChemE/anti-mers-3

37、a1-mab.html Anti-MERS-3A1 HYPERLINK https:/www.MedChemE/anti-mers-3a1-mab.html HYPERLINK https:/www.MedChemE/anti-mers-3a1-mab.html mAb(MERS-3A1; MERS Antibody-3A1) Cat. No.: HY-P9805 HYPERLINK https:/www.MedChemE/anti-mers-d12-mab.html Anti-MERS-D12 HYPERLINK https:/www.MedChemE/anti-mers-d12-mab.h

38、tml HYPERLINK https:/www.MedChemE/anti-mers-d12-mab.html mAb(MERS-D12; MERS Antibody-D12) Cat. No.: HY-P9806Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonalIgG1 antibody with the high binding affinityproduced in CHO cells. Anti-MERS-3A1 mAb bocks thebinding of MERS-CoV spike protein to DPP4recepto

39、r.Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) isa human monoclonal IgG1. Anti-MERS-D12 mAb bindsdirectly to the DPP4 interacting region of theMERS-CoV Spike receptor binding domain (RBD) andeffect neutralization by directly blockingreceptor binding.Purity: 98%Clinical Data: No Development Report

40、edSize: 100 g, 500 gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/anti-sars-80r-mab.html Anti-SARS-80R HYPERLINK https:/www.MedChemE/anti-sars-80r-mab.html HYPERLINK https:/www.MedChemE/anti-sars-80r-mab.html mAb(SARS-80R; SARS Antibody-80R) Cat. No.

41、: HY-P9803 HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.html Anti-SARS-CoV-2 HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.html HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.html Spike HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.

42、html HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.html mAb HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.html HYPERLINK https:/www.MedChemE/anti-sars-cov-2-spike-mab-cr3022.html (CR3022)(SARS-CR3022; SARS-CoV-2 Antibody-CR3022) Cat. No.: HY-P9807Anti-SARS-80R mAb (

43、SARS-80R) is a human monoclonalIgG1 antibody produced in CHO cells. Anti-SARS-80RmAb can specifically bind to Spike (S1) protein toprevent SARS virus infection of susceptiblecells.Anti-SARS-CoV-2 Spike mAb (CR3022) is a a CHO cellderived human monoclonal IgG1 antibody. It bindsto both S1 domain of S

44、ARS-CoV/SARS-CoV-2 Spikeprotein.Purity: 95.00%Clinical Data: No Development ReportedSize: 100 g, 500 gPurity: 95.00%Clinical Data: No Development ReportedSize: 100 g, 500 g HYPERLINK https:/www.MedChemE/anti-spike-rbd-mab.html Anti-Spike-RBD HYPERLINK https:/www.MedChemE/anti-spike-rbd-mab.html HYPE

45、RLINK https:/www.MedChemE/anti-spike-rbd-mab.html mAb HYPERLINK https:/www.MedChemE/anti-spike-rbd-mab.html HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-domain-mab.html Anti-Spike-RBD HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-domain-mab.html HYPERLINK https:/www.MedChemE/anti-spike-

46、rbd-single-domain-mab.html Single HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-domain-mab.html HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-domain-mab.html Domain HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-domain-mab.html HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-dom

47、ain-mab.html mAb HYPERLINK https:/www.MedChemE/anti-spike-rbd-single-domain-mab.html (SARS-CoV-2 (2019-nCoV)(SARS-CoV-2 (2019-nCoV) Spike RBD Antibody) Cat. No.: HY-P9801 Single-Domain Antibodies; ) Cat. No.: HY-P9802Anti-Spike-RBD mAb is a CHO cell derived humanmonoclonal IgG1 antibody. Blocking th

48、e interactionof Spike protein and ACE2. Anti-Spike-RBD mAb is apotential therapeutic approach for SARS-CoV-2treatment.Anti-Spike-RBD Single Domain mAb is a CHO cellderived Alpaca monoclonal VHH-huFc antibody,specifically binds to SARS-CoV-2 RBD with highaffinity.Purity: 95.0%Clinical Data: No Develo

49、pment ReportedSize: 100 g, 500 gPurity: 98%Clinical Data: No Development ReportedSize: 100 g, 500 g HYPERLINK https:/www.MedChemE/antiviral-agent-15.html Antiviral HYPERLINK https:/www.MedChemE/antiviral-agent-15.html HYPERLINK https:/www.MedChemE/antiviral-agent-15.html agent HYPERLINK https:/www.M

50、edChemE/antiviral-agent-15.html HYPERLINK https:/www.MedChemE/antiviral-agent-15.html 15 HYPERLINK https:/www.MedChemE/antiviral-agent-15.html HYPERLINK https:/www.MedChemE/antiviral-agent-5.html Antiviral HYPERLINK https:/www.MedChemE/antiviral-agent-5.html HYPERLINK https:/www.MedChemE/antiviral-a

51、gent-5.html agent HYPERLINK https:/www.MedChemE/antiviral-agent-5.html HYPERLINK https:/www.MedChemE/antiviral-agent-5.html 5Cat. No.: HY-144623 Cat. No.: HY-139683Antiviral agent 15 (Compound 15f) is a Clofaziminederivative with antiviral effects. Antiviral agent15 inhibits both rabies virus and ps

52、eudo-typedSARS-CoV-2 with EC values of 1.45 M and 14.650M, respectively.Antiviral agent 5 is an intermediate used inantiviral agents targeting 3C and 3CL proteasesincluding SARS-CoV-2 Mpro.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development Repor

53、tedSize: 1 mg, 5 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/arteannuin-b.html Arteannuin HYPERLINK https:/www.MedChemE/arteannuin-b.html HYPERLINK https:/www.MedChemE/arteannuin-b.html BCat. No.: HY-N2016 HYPERLINK https:/www.MedChemE/Asunaprevir.html

54、Asunaprevir(BMS-650032) Cat. No.: HY-14434Arteannuin B co-occurs with artemisinin, which isthe potent antimalarial principle of the Chinesemedicinal herb Artemisia annua (Asteraceae).Arteannuin B shows anti-SARS-CoV-2 potential withan EC of 10.28 M.50Asunaprevir (BMS-650032) is a potent and orallybi

55、oavailable hepatitis C virus (HCV) NS3 proteaseinhibitor, with IC of 0.2 nM-3.5 nM. Asunaprevir50inhibits SARS-CoV-2 3CLpro activity.Purity: 99.27%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.71%Clinical Data: LaunchedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 50 mg HYPERLINK https:/w

56、ww.MedChemE/at-9010.html AT-9010 HYPERLINK https:/www.MedChemE/at-9010.html HYPERLINK https:/www.MedChemE/at-9010-tetrasodium.html AT-9010 HYPERLINK https:/www.MedChemE/at-9010-tetrasodium.html HYPERLINK https:/www.MedChemE/at-9010-tetrasodium.html tetrasodiumCat. No.: HY-139165 Cat. No.: HY-139165A

57、AT-9010, a triphosphate active metabolite ofAT-527, is a potent inhibitor of NiRAN (a functionessential for viral replication). AT-9010 caninhibit SARS-CoV-2 replication.AT-9010 tetrasodium, a triphosphate activemetabolite of AT-527, is a potent inhibitor ofNiRAN (a function essential for viral repl

58、ication).AT-9010 tetrasodium can inhibit SARS-CoV-2replication.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.74%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/at-9010-triethylamine.html AT-9010 HYPERLINK https:/www.MedChemE/a

59、t-9010-triethylamine.html HYPERLINK https:/www.MedChemE/at-9010-triethylamine.html triethylamineCat. No.: HY-139165B HYPERLINK https:/www.MedChemE/atazanavir.html Atazanavir(BMS-232632) Cat. No.: HY-17367AT-9010 triethylamine, a triphosphate activemetabolite of AT-527, is a potent inhibitor ofNiRAN

60、(a function essential for viral replication).AT-9010 triethylamine can inhibit SARS-CoV-2replication.Atazanavir (BMS-232632), a highly selective HIV-1protease inhibitor, is the first proteaseinhibitor approved for once-daily administration.Atazanavir (BMS-232632) is a substrate andinhibitor of CYP3A