Influenza-Virus-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html Influenza HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html VirusInfluenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded nega

2、tive sense RNAviruses. The group includes three types of influenza viruses, A, B and C. Type B and C viruses only infect humans, but the type Aviruses infect humans, horses, swine, other mammals, and a wide variety of domesticated and wild birds. Human influenza A and Bviruses cause seasonal epidemi

3、cs of disease almost every winter in the United States. The emergence of a new and very differentinfluenza virus to infect people can cause an influenza pandemic. Influenza type C infections cause a mild respiratory illness and arenot thought to cause epidemics. Each virus subtype has mutated into a

4、 variety of strains with differing pathogenic profiles; someare pathogenic to one species but not others, some are pathogenic to multiple species.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html Influenza HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html HYPERLINK h

5、ttps:/www.MedChemE/Targets/Influenza Virus.html Virus HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html Inhibitors HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html

6、 & HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html HYPERLINK https:/www.MedChemE/Targets/Influenza Virus.html Antagonists HYPERLINK https:/www.MedChemE/1-deoxymannojirimycin-hydrochloride.html 1-Deoxymannojirimycin HYPERLINK https:/www.MedChemE/1-deoxymannojirimycin-hydrochloride.html HYP

7、ERLINK https:/www.MedChemE/1-deoxymannojirimycin-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/1-deoxymannojirimycin-hydrochloride.html HYPERLINK https:/www.MedChemE/2-deoxy-2-fluorocytidine.html 2-Deoxy-2-fluorocytidineCat. No.: HY-W009783 Cat. No.: HY-W0120091-Deoxymannojirimycin

8、hydrochloride is a selectiveclass I 1,2-mannosidase inhibitor with an IC50of 20 M. 1-Deoxymannojirimycin hydrochloride isalso a N-linked glycosylation inhibitor and inhibitsHIV1 strains. 1-Deoxymannojirimycin hydrochloridehas antiviral activity.2-Deoxy-2-fluorocytidine, an nucleoside analog,is a pot

9、ent inhibitor of Crimean-Congohemorrhagic fever virus (CCHFV) replication.Purity: 98.28%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mgPurity: 99.09%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/2-deoxy-2-fluorouridine.html 2-Deoxy-2-fluoro

10、uridineCat. No.: HY-W013403 HYPERLINK https:/www.MedChemE/2-3-dehydro-2-deoxy-n-acetylneuraminic-acid.html 2,3-Dehydro-2-deoxy-N-acetylneuraminic HYPERLINK https:/www.MedChemE/2-3-dehydro-2-deoxy-n-acetylneuraminic-acid.html HYPERLINK https:/www.MedChemE/2-3-dehydro-2-deoxy-n-acetylneuraminic-acid.h

11、tml acid(Neu5Ac2en; DANA) Cat. No.: HY-1257982-Deoxy-2-fluorouridine can be used as anintermediate for antiinfluenza virus agentssynthesis.N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid(Neu5Ac2en) is a potent neuraminidase(sialidase) inhibitor.Purity: 99.71%Clinical Data: No Development ReportedSize: 1

12、0 mM 1 mL, 500 mgPurity: 95.0%Clinical Data: No Development ReportedSize: 5 mg HYPERLINK https:/www.MedChemE/2-deoxy-2-fluoroguanosine.html 2-Deoxy-2-fluoroguanosineCat. No.: HY-W011518 HYPERLINK https:/www.MedChemE/3,4_acute_-Dihydroxyflavone.html 3,4-Dihydroxyflavone(3,4-DHF) Cat. No.: HY-1118022-

13、Deoxy-2-fluoroguanosine, a nucleoside analog,is a potent inhibitor of influenza virus strains,with an EC90 of 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/3m-011.html 3M-011 HYPERLINK https:/www.MedChemE/3m-011.html HYPERLINK https:/www.MedChemE/5-a

14、minouridine.html 5-AminouridineCat. No.: HY-121496 Cat. No.: HY-1308023M-011 is a potent dual toll-like receptor TLR7/8agonist and a cytokine inducer. 3M-011significantly inhibits H3N2 influenza viralreplication in the nasal cavity.5-Aminouridine can modify nucleobases and can beincorporated into th

15、e target DNA. 5-Aminouridineexhibits a wide range of biological activity andit inhibits the growth of tumors, fungi and viruses.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Emai

16、l: salesMedChemE HYPERLINK https:/www.MedChemE/6-azathymine.html 6-AzathymineCat. No.: HY-136559 HYPERLINK https:/www.MedChemE/6-diazo-5-oxo-l-nor-leucine.html 6-Diazo-5-oxo-L-nor-Leucine(L-6-Diazo-5-oxonorleucine; DON) Cat. No.: HY-1083576-Azathymine, a 6-nitrogen analog of thymine, is apotent D-3-

17、aminoisobutyrate-pyruvateaminotransferase inhibitor. 6-Azathymineinhibits the biosynthesis of DNA, and hasantibacterial and antiviral activities.L-6-Diazo-5-oxonorleucine(L-6-Diazo-5-oxonorleucine) is a glutaminasesantagonist with a K of 6 M.iL-6-Diazo-5-oxonorleucine exhibits antibacterial,antivira

18、l and anticancer properties.Purity: 98%Clinical Data: No Development ReportedSize: 100 mg, 250 mg, 500 mgPurity: 99.92%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg HYPERLINK https:/www.MedChemE/abma.html ABMACat. No.: HY-124801 HYPERLINK https:/www.MedChemE/Acetylcysteine.html

19、Acetylcysteine(N-Acetylcysteine; N-Acetyl-L-cysteine; NAC) Cat. No.: HY-B0215ABMA is a broad-spectrum inhibitor ofintracellular toxins and pathogens. ABMAefficiently protects cells against various toxinsand pathogens including viruses, intracellularbacteria and parasite.Acetylcysteine (N-Acetylcyste

20、ine) is amucolytic agent which reduces the thickness ofthe mucus. Acetylcysteine is a ROS inhibitor.Purity: 99.61%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98.0%Clinical Data: LaunchedSize: 500 mg, 5 g, 10 g HYPERLINK https:/www.MedChemE/acetylcysteine-15n.h

21、tml Acetylcysteine-15N(N-Acetylcysteine-15N; N-Acetyl-L-cysteine-15N; NAC-15N) Cat. No.: HY-B0215S1 HYPERLINK https:/www.MedChemE/acetylcysteine-d3.html Acetylcysteine-d3(N-Acetylcysteine-d3; N-Acetyl-L-cysteine-d3; NAC-d3) Cat. No.: HY-B0215SAcetylcysteine-15N (N-Acetylcysteine-15N) is the15N-label

22、ed Acetylcysteine. Acetylcysteine(N-Acetylcysteine) is a mucolytic agent whichreduces the thickness of the mucus. Acetylcysteineis a ROS inhibitor.Acetylcysteine-d3 (N-Acetylcysteine-d3) is thedeuterium labeled Acetylcysteine. Acetylcysteine(N-Acetylcysteine) is a mucolytic agent whichreduces the th

23、ickness of the mucus. Acetylcysteineis a ROS inhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/AEBSF.html AEBSF HYPERLINK https:/www.MedChemE/AEBSF.html HYPERLINK https:/www.MedCh

24、emE/AEBSF.html hydrochloride HYPERLINK https:/www.MedChemE/AEBSF.html HYPERLINK https:/www.MedChemE/ag-1478.html AG-1478Cat. No.: HY-12821(Tyrphostin AG-1478; NSC 693255) Cat. No.: HY-13524AEBSF hydrochloride is an irreversible inhibitorof serine proteases, such as chymotrypsin,kallikrein, plasmin,

25、thrombin, and trypsin.AG-1478 (Tyrphostin AG-1478) is a selective EGFRtyrosine kinase inhibitor with IC of 3 nM.50AG-1478 has antiviral effects against HCV andencephalomyocarditis virus (EMCV).Purity: 99.90%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg, 200 mgPurity: 99.22%Clinical

26、Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/ag-1478-hydrochloride.html AG-1478 HYPERLINK https:/www.MedChemE/ag-1478-hydrochloride.html HYPERLINK https:/www.MedChemE/ag-1478-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/ag-

27、1478-hydrochloride.html (Tyrphostin AG-1478 hydrochloride; NSC HYPERLINK https:/www.MedChemE/amantadine.html Amantadine693255 hydrochloride) Cat. No.: HY-13524A (1-Adamantanamine; 1-Aminoadamantane) Cat. No.: HY-B0402AG-1478 hydrochloride (Tyrphostin AG-1478hydrochloride) is a selective EGFR tyrosin

28、ekinase inhibitor with IC of 3 nM. AG-147850hydrochloride has antiviral effects against HCVand encephalomyocarditis virus (EMCV).Amantadine (1-Adamantanamine) is an antiviralagent with activity against influenza A viruses.Amantadine blocks the proton flow through the M2ion channel (M2 proton channel

29、 of influenza A) andthus prevents the release of viral RNA into thecytoplasm of the infected cells.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/Amantadine-hydrochloride.html A

30、mantadine HYPERLINK https:/www.MedChemE/Amantadine-hydrochloride.html HYPERLINK https:/www.MedChemE/Amantadine-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/Amantadine-hydrochloride.html (1-Adamantanamine hydrochloride;1-Adamantylamine hydrochloride; ) Cat. No.: HY-B0402A HYPERLINK

31、https:/www.MedChemE/amantadine-d15.html Amantadine-d15(1-Adamantanamine-d15; 1-Aminoadamantane-d15) Cat. No.: HY-B0402SAmantadine (1-Adamantanamine) hydrochloride is anantiviral agent with activity against influenza Aviruses. Amantadine hydrochloride blocks theproton flow through the M2 ion channel

32、and thusprevents the release of viral RNA into thecytoplasm of the infected cells.Amantadine-d15 (1-Adamantanamine-d15) is thedeuterium labeled Amantadine. Amantadine(1-Adamantanamine) is an antiviral agent withactivity against influenza A viruses.Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL

33、, 500 mg, 5 g, 10 g, 50 gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/amitivir.html Amitivir(LY 217896) Cat. No.: HY-106817 HYPERLINK https:/www.MedChemE/andrographolide.html Andrographolide(Andrographis) Cat. No.: HY-N0191Amitivir (LY 217896), a th

34、iadiazole derivative,possesses broad antiviral activity againstorthomyxo- and paramyxoviruses. Amitivir iseffective against influenza A and B viruses.Andrographolide is a NF-B inhibitor, whichinhibits NF-B activation through covalentmodification of a cysteine residue on p50 inendothelial cells witho

35、ut affecting IBdegradation or p50/p65 nuclear translocation.Andrographolide has antiviral effects.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.57%Clinical Data: LaunchedSize: 100 mg, 500 mg HYPERLINK https:/www.MedChemE/Aprotinin.html AprotininCat. No.: HY-P0017 HYPERL

36、INK https:/www.MedChemE/Arctigenin.html Arctigenin(-)-Arctigenin) Cat. No.: HY-N0035Aprotinin is a bovine pancreatic trypsin inhibitor(BPTI) inhibitor which inhibits trypsin andchymotrypsin with Ks of 0.06 pM and 9 nM,irespectively.Arctigenin (-)-Arctigenin), a biologically activelignan, can be used

37、 as an antitumor agent.Arctigenin exhibits potent antioxidant,anti-inflammatory and antiviral (influenza A virus)activities.Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.69%Clinical Data: Phase 2Size: 10 mM 1 mL, 10 mg, 50 mg, 100 mg HYPERLINK http

38、s:/www.MedChemE/aurintricarboxylic-acid.html Aurintricarboxylic HYPERLINK https:/www.MedChemE/aurintricarboxylic-acid.html HYPERLINK https:/www.MedChemE/aurintricarboxylic-acid.html acid HYPERLINK https:/www.MedChemE/aurintricarboxylic-acid.html HYPERLINK https:/www.MedChemE/azadirachtin-b.html Azad

39、irachtin HYPERLINK https:/www.MedChemE/azadirachtin-b.html HYPERLINK https:/www.MedChemE/azadirachtin-b.html BCat. No.: HY-122575 Cat. No.: HY-133108Aurintricarboxylic acid is a nanomolar-potency,allosteric antagonist with selectivity towards-methylene-ATP-sensitive P2X1Rs and P2X3Rs,with IC s of 8.

40、6 nM and 72.9 nM for rP2X1R and50rP2X3R, respectively.Azadirachtin B is an limonoid isolated from seedkernels of Azadirachta indica. Azadirachtin Bincreases alkaline phosphatase (ALP) activity andstimulates osteoblast differentiation.Azadirachtin B is active against the Epstein-Barrvirus early antig

41、en (EBV-EA).Purity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/Baicalein.html Baicalein HYPERLINK https:/www.MedChemE/Baicalein.html HYPERLINK https:/www.MedChemE/Baloxavir.ht

42、ml Baloxavir(5,6,7-Trihydroxyflavone) Cat. No.: HY-N0196 (Baloxavir acid; S-033447) Cat. No.: HY-109025ABaicalein (5,6,7-Trihydroxyflavone) is a xanthineoxidase inhibitor with an IC value of 3.12 M.50Baloxavir (Baloxavir acid), derived from theprodrug Baloxavir marboxil, is a first-in-class,potent a

43、nd selective cap-dependent endonuclease(CEN) inhibitor within the polymerase PA subunitof influenza A and B viruses.Purity: 99.13%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mgPurity: 99.80%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg4 Tel: 609-228-6898

44、Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Baloxavir_marboxil.html Baloxavir HYPERLINK https:/www.MedChemE/Baloxavir_marboxil.html HYPERLINK https:/www.MedChemE/Baloxavir_marboxil.html marboxil(S-033188) Cat. No.: HY-109025 HYPERLINK https:/www.MedChemE/baloxavir-d5.html Ba

45、loxavir-d5(Baloxavir acid-d5; S-033447-d5) Cat. No.: HY-109025ASBaloxavir marboxil (S-033188) is a selectiveinhibitor of influenza cap-dependent endonuclease.Baloxavir marboxil, a potent antiviral agent,shows activity against influenza A and B virus.Baloxavir-d5 is deuterium labeled Baloxavir.Baloxa

46、vir (Baloxavir acid), derived from theprodrug Baloxavir marboxil, is a first-in-class,potent and selective cap-dependent endonuclease(CEN) inhibitor within the polymerase PA subunitof influenza A and B viruses.Purity: 98.94%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPu

47、rity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Camphor.html Camphor()-Camphor) Cat. No.: HY-N0808 HYPERLINK https:/www.MedChemE/camphor-d6.html Camphor-d6()-Camphor-d6) Cat. No.: HY-N0808SCamphor ()-Camphor) is a topical anti-infectiveand anti-pruritic

48、and internally as a stimulantand carminative. However, Camphor is poisonouswhen ingested. Antiviral, antitussive, andanticancer activities. Camphor is a TRPV3agonist.Camphor-d6 ()-Camphor-d6) is the deuteriumlabeled Camphor. Camphor ()-Camphor) is atopical anti-infective and anti-pruritic andinterna

49、lly as a stimulant and carminative.However, Camphor is poisonous when ingested.Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Campathecin.html Camptothecin(Campathecin; (S)-(+)-Camptothecin;

50、CPT) Cat. No.: HY-16560 HYPERLINK https:/www.MedChemE/camptothecin-d5.html Camptothecin-d5(Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5) Cat. No.: HY-16560SCamptothecin (CPT), a kind of alkaloid, is a DNAtopoisomerase I (Topo I) inhibitor with an IC of50679 nM.Camptothecin-d5 (Campathecin-d5) is

51、the deuteriumlabeled Camptothecin. Camptothecin (CPT), a kindof alkaloid, is a DNA topoisomerase I (Topo I)inhibitor with an IC of 679 nM.50Purity: 99.69%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedC

52、hemE/cap-dependent-endonuclease-in-10.html Cap-dependent HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-10.html HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-10.html endonuclease-IN-10 HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-10.html HYPERLINK https:/www

53、.MedChemE/cap-dependent-endonuclease-in-11.html Cap-dependent HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-11.html HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-11.html endonuclease-IN-11Cat. No.: HY-143757 Cat. No.: HY-143760Cap-dependent endonuclease-IN-10 is a potenti

54、nhibitor of cap-dependent endonuclease (CEN).Cap-dependent endonuclease-IN-11 is a potentinhibitor of cap-dependent endonuclease (CEN).Cap-dependent endonuclease-IN-11 has the potentialfor the research of viral infections (extractedfrom patent WO2021129602A1, compound DSC126).Purity: 98%Clinical Dat

55、a: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-12.html Cap-dependent HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-12.html HYPERLINK https:/www.MedChemE/cap-dependen

56、t-endonuclease-in-12.html endonuclease-IN-12 HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-12.html HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-13.html Cap-dependent HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-13.html HYPERLINK https:/www.MedChemE/cap-dep

57、endent-endonuclease-in-13.html endonuclease-IN-13Cat. No.: HY-143762 Cat. No.: HY-143766Cap-dependent endonuclease-IN-12 (EXP-35) is apotent Cap-dependent endonuclease inhibitor withlow cytotoxicity. Cap-dependent endonuclease-IN-12shows inhibitory activity against H1N1.Cap-dependent endonuclease-IN

58、-13 is a potentinhibitor of cap-dependent endonuclease (CEN).Cap-dependent endonuclease-IN-13 has the potentialfor the research of influenza virus infection(only influenza A) (extracted from patentWO2021180147A1, compound I-1).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity:

59、98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 5 HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-14.html Cap-dependent HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-14.html HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-14.html endonuclea

60、se-IN-14 HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-14.html HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-15.html Cap-dependent HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-15.html HYPERLINK https:/www.MedChemE/cap-dependent-endonuclease-in-15.html endon