磁性氧化铁纳米颗粒及其在MRI中的应用

1、Contents第五章第五章 阿瑞匹坦固体分散体和纳米混悬剂离体肠吸收研究阿瑞匹坦固体分散体和纳米混悬剂离体肠吸收研究第三章第三章 阿瑞匹坦纳米混悬剂的制备及药剂学性质研究阿瑞匹坦纳米混悬剂的制备及药剂学性质研究第一章第一章 阿瑞匹坦体外分析方法的建立和理化性质研究阿瑞匹坦体外分析方法的建立和理化性质研究前言前言第四章第四章 阿瑞匹坦固体分散体和纳米混悬剂体内药动学研究阿瑞匹坦固体分散体和纳米混悬剂体内药动学研究第六章第六章 阿瑞匹坦固体分散体和纳米混悬剂阿瑞匹坦固体分散体和纳米混悬剂Caco-2细胞跨膜转运研究细胞跨膜转运研究第二章第二章 阿瑞匹坦纳米混悬剂的制备及药剂学性质研究阿瑞匹坦纳米

2、混悬剂的制备及药剂学性质研究前言前言第一章阿瑞匹坦体外分析方法的建立及理化性质研究第一章阿瑞匹坦体外分析方法的建立及理化性质研究Company LogoSIntroductionStructure of MRI functioned magnetic nanoparticlesIntroductionPreparation of MRI functioned magnetic nanoparticlesPreparation of the core of the particleProtection/Stabilization of particlesFunctionalizationProt

3、ection/Stabilization of Magnetic ParticlesSurface Passivation by Mild OxidationSurfactant and Polymer CoatingPrecious-Metal CoatingMatrix-Dispersed Magnetic NanoparticlesSilica CoatingCarbon CoatingForm a core-shell structurethat isolate the core with the environmentProtection/Stabilization of Magne

4、tic ParticlesSurfactant and Polymer CoatingSurfactants or polymers can be chemically anchored or physically adsorbed on magnetic nanoparticles to form a single or double layer which creates repulsive(mainly as steric repulsion) forces to balance the magnetic and the van der Waals attractive forces a

5、cting on the nanoparticles. Polymers containing functional groups, such as carboxylic acids, phosphates, and sulfates, can bind to the surface of magnetite.Protection/Stabilization of Magnetic ParticlesSurfactant and Polymer CoatingProtection/Stabilization of Magnetic ParticlesSurfactant and Polymer

6、 Coating(chemical combination)Example: FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agentsProtection/Stabilization of Magnetic ParticlesSurfactant and Polymer Coating(chemical combination)Protection/Stabilization of Magnetic ParticlesSurfactant and Polym

7、er Coating(chemical combination)Protection/Stabilization of Magnetic Particles Example: Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probesSurfactant and Polymer Coating(physical combination)Protection/Stabilization of Magnetic ParticlesSurfactant and Polymer Coating(phys

8、ical combination)Protection/Stabilization of Magnetic ParticlesExample: Maghemite Nanoparticles Protectively Coated with Poly(ethylene imine) and Poly(ethylene oxide)-block-poly(glutamic acid)Surfactant and Polymer Coating(physical combination)Protection/Stabilization of Magnetic ParticlesA:before i

9、njectionB:after injection maghemite nanoparticles(0.6 mg of Fe/kg)C:before injectionD:after injection Resovist(0.6 mg of Fe/kg)Magnetic resonance signal intensity of liver parenchymaof rats in T2-weighted sequences.Surfactant and Polymer Coating(physical combination)Protection/Stabilization of Magne

10、tic ParticlesSilica CoatingThis coating stabilizes the magnetite nanoparticles in two different ways. One is by shielding the magnetic dipole interaction with the silica shell. On the other hand, the silica nanoparticles are negatively charged. Therefore, the silica coating enhances the coulomb repu

11、lsion of the magnetic nanoparticles.Silica coatings have several advantages arising from their stability under aqueous conditions (at least if the pH value is sufficiently low), easy surface modification, and easy control of interparticle interactions, both in solution and within structures, through

12、variation of the shell thickness.Protection/Stabilization of Magnetic ParticlesSilica CoatingProtection/Stabilization of Magnetic ParticlesCarbon CoatingCarbon-based materials have many advantages over polymer or silica, such as much higher chemical and thermal stability as well as biocompatibility.

13、Though carbon-coated magnetic nanoparticles have manyadvantageous properties, such particles are often obtained asagglomerated clusters, owing to the lack of effective syntheticmethods, and a low degree of understanding of the formationmechanism. The synthesis of dispersible, carbon-coated nanoparti

14、cles in isolated form is currently one of the challenges in this field.Protection/Stabilization of Magnetic ParticlesMatrix-Dispersed Magnetic NanoparticlesProtection/Stabilization of Magnetic ParticlesMatrix-Dispersed Magnetic NanoparticlesSPIO-loaded Carbon nanotubesStructural and Physicochemical

15、CharacterizationMagnetic Properties CharacterizationSize, Polydispersity, Shape, Surface CharacterizationCharacterizationStructural and Physicochemical Characterization Size, Polydispersity, Shape, and Surface CharacterizationTransmission electron microscope（TEM）High-Resolution Transmission electron

16、 microscope（HRTEM）Structural and Physicochemical Characterization Size, Polydispersity, Shape, and Surface CharacterizationX-Ray diffraction（XRD） Dynamic light scattering（DLS）Scanning electron microscope（SEM）Structural and Physicochemical Characterization Magnetic Properties Characterization superpa

17、ramagnetismSaturation magnetizationCoercive field strengthRemained magnetic field strengthStructural and Physicochemical Characterization Magnetic Properties Characterization T2 relaxivityStructural and Physicochemical Characterization Other Properties Characterization Magnetic content Stability Aci

18、d and alkali resistance Functionalization and Applications of Magnetic Nanoparticles Functionalization and Applications of Magnetic Nanoparticles Functionalization and Applications of Magnetic Nanoparticles Example: A novel strategy for surface modification of superparamagnetic iron oxide nanopartic

19、les for lung cancer imaging Functionalization and Applications of Magnetic Nanoparticles Functionalization and Applications of Magnetic Nanoparticles Functionalization and Applications of Magnetic Nanoparticles Functionalization and Applications of Magnetic Nanoparticles Conclusions and PerspectivesFor in vitro and in vivo stabilization, the surfaces of magnetic iron oxide nanoparticles are usually coated with various hydrophilic/amphiph