补肾活血汤论文：补肾活血汤心理因素卵巢功能减退肝郁肾虚

1、肾虚【中文摘要】阐明补肾活血疗法对外界不良刺激后心理精神因素导致卵巢功能减退的影响，研究补肾活血汤对此类患者的干预作用，阐明作用机理，为中医药防治卵巢功能衰退提供科学依据。方法：将40例有不良心理刺激诱因、中医辨证为肝郁肾虚型的卵巢功能减退患者，随机分为治疗组20例（予补肾活血汤口服治疗3个月）和对照组20例（倍美力+安宫黄体酮序贯疗法治疗3个周期）。观察治疗前后临床症状、体征的改善情况，治疗前后E2、FSHLH水平及治疗前后OVDAFGRI的变化及安全观察；观察治疗后治疗组与对照组组间的差异性。结果：1、治疗后治疗组综合疗效有效率为85%,中医症状疗效有效率为85%对照组综合疗效有效率为70

2、%,中医症状疗效有效率为75%两组统计无显著差异（P>0.05）。治疗后两组在调经及临床症状上均有所改善，且治疗组对腰膝酸软的改善作用明显优于对照组（P0.05）;治疗后两组组间比较FSHLH有显著差异（P0.05）。3、治疗组与对照组OVD台疗前后均无显著性差异（P0.05）;治疗组与对照组AFCRI治疗前后均有极显著差异（PvO.001）,两组组间比较亦有显著差异（PV0.05）。结论：补肾活血汤具有调经及改善心因性卵巢功能减退患者临床症状的作用，改善腰膝酸软的作用优于HRTB;补肾活血汤能调整下丘脑-垂体-卵巢轴的功能，降低FSHLH水平，升高E2水平,促进卵泡发育，改善卵巢血供，

3、从而可以改善卵巢功能。【英文摘要】：Toobservetheinflueneethatthetherapyoftonifyingkidneyandaetivatingtheeireulationofbloodonthedecreasedovarianreserve(DOR)indueedbypsychologicalstress.Toinvestigatetheelinicaleffeetandmeehanismofbu-shen-huo-xuedeeoetiontreatingthosepatients.Thestudyexpecttoprovideaneffectivenewbasisfo

4、rpreventingdecreasedovarianreserve.Methods:FortywomenwithDORnducedbyexcessiveemotions(distinetion:renaldefieiencyandliverstagnation)weredividedrandomlyintotwogroups:therapy-group(20eases,treatedwithbu-shen-huo-xuedeeoetion)andeontroled-group(20eases,hormonereplaeementtherapy:estradiolvalerateandmedr

5、oxyprogesterone).Theehangesofelinicalsymptomsandsigns,serumhormones(E2、FSHLH),ovarybloodflowindiees(OVD、AFCRI)andsafetyindiceswereobservedbeforeandaftertreatment.Andthedifferencesbetweentherapy-groupandeontroled-groupwereobserved.Results:1、Thetotaleffectiverateofthetherapy-groupwas85%,whiletheeontro

6、led-groupwas70%.Bymeansofstatisticalanalysis,therewasnosignificantdiffereneebetweentwogroups(P>0.05).Aftertreatment,themenstrualfunetionandelinicalsymptomsoftwogroupswereimproved,andthesymptomsofwaistandkneesourandweakintherapy-groupwereobviouslybetterthancontroled-group(P0.05).Thetherapy-groupwa

7、ssuperiortothecontroled-grouponthelevelofFSHandLH(P<0.05).3、TheAFCandRIhaveextremelysignificantdifferencesinbothgroupsaftertreatment(P<0.001).Therewerealsosignificantdifferencesbetweentherapy-groupandcontroled-group(P<0.05).ButOVDdidn't.Conclusion:Bu-shen-huo-xuedecoctioncaneffectivelyt

8、reatfemalemenstrualdisorderandclinicalsymptomsofdecreasedovarianreserve,anditisobviouslybetterthancontroled-grouponimprovingthesymptomsofwaistandkneesourandweak.Bu-shen-huo-xuedecoctioncanregulatethefunctionofhypothalamus-pituitary-ovaryaxis,decreasethelevelofgonadotropin,increasethelevelofestrogen,promoteovulation,andimprovetheovarybloodsupply,thereforeimprovetheovarianfunction.【关键词】补肾活血汤心理因素卵巢功能减退肝郁肾虚【英文关键词】bu-shen-huo-xued