抗生素ppt课件(1)

1、ROHOHOHOHOOCH3RN(CH3)2OHHHCONH2123456789101112OHOOHOCONH2OHOHHHOHNABCD123456789101112OHOOHOCONH2OHOHHHOHNOH5-OHOHOOHOCONH2OHOHHHOHNCl7-ClROHOHOHOHOOCH3RN(CH3)2OHCONH2123456789101112OHOOHOCONH2OHCH3OHHHOHNHH2O_OHOHOOCONH2OHHOHNCH3OHOOHOCONH2OHCH3OHHHOHNOHOHOOCONH2OHHOHNCH3PH2-64N(CH3)24N(CH3)2OHOOHOC

2、ONH2OHOHOHNOHOHOOHOCONH2OHCH3OHHHOHNOHOHOOHOCONH2OHH3COHOHNOHOOOCONH2OHH3COHNOHHOHOOOCONH2OHOHHHOHN123561112Ca 鉴别鉴别: Fe-: Fe-四环素四环素 红色红色 Al- Al-四环素四环素 黄色黄色 Ca- Ca-四环素四环素 黄色黄色 与血液中金属离子结合影响血药物浓度与血液中金属离子结合影响血药物浓度 与牙、骨骼中钙络合，导致四环素牙；影响骨骼生长与牙、骨骼中钙络合，导致四环素牙；影响骨骼生长OHOOHOCONH2OHNOHCH3OHHOOHOOHOCONH2OHNOHCH2OH

3、3 3二甲胺四环素米诺环素二甲胺四环素米诺环素 作用添加作用添加, ,对各种耐药菌有效对各种耐药菌有效OHOOHOCONH2OHHHOHNOHCH3OHOOHOCONH2OHHHOHNNROHOHOHOHOOCH3RN(CH3)2OHHHCONH2123456789101112OCH2NH2HOHOOHOHOH2NNH2OHOH2NOHONH2()CH2OHOCH2NH2HOHOOHOHOH2NNHCOCH(CH2)2NH2OHOH2NOHOOHH HO OH H2 2C COCH2NH2HOONH2HOH2NNH2OHOH2NOHOCH2OHOCH3OOCH3H3COHOHCH3HOH3CC

4、H3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3O6912 1克拉定糖11108脱氧氨基HO3NOROOHCH3OH3CCH3CH3CH3H3CCH3OOCH3CH3CH3ORH3COHCH3OR1CH3OOCH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3O6912CH3OOCH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3O6912CH3OOCH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3C

5、H3O2.-H2OCH3OCH3H3COHOCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3OCH3OCH3H3CHOOCH3OH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3OCH3OCH3H3CHOOCH3OH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3OH+HO1.H+6912CH3OOCH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3RONCH3CH3CH3O红霉素碳酸乙酯红霉素硬脂酸酯依托红霉素琥乙红霉素R=COOCH2CH3R=CO(CH2)16CH3R=CO(C

6、H2)2OCOCH2CH3R=CO2CH2CH3.C12H25SO3HCH3OOCH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3O6912CH3OOCH3H3COHOCH3CH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3OCH3ONOCH2OCH2CH2OCH3CH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3OCH3OOCH3H3COHOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3OFCH3OCH3H3CO

7、HOHCH3HOH3CCH3OH3COOOCH3OHCH3OCH3HONCH3CH3CH3ONH3COOOCH3H3COR1CHOOOOHONCH3CH3CH3OOR2CH3H3COR3OH3CONCH3CH3CH3螺旋霉素 R1=H R2=H R3=H螺旋霉素 R1=COCH3 R2=H R3=H螺旋霉素 R1=COC2H5 R2=H R3=H乙酰螺旋霉素 R1=H R2=H R3=COCH3乙酰螺旋霉素 R1=COCH3 R2=H R3=COCH3乙酰螺旋霉素 R1=COC2H5 R2=COCH3 R3=COCH3麦迪霉素 A1OROCH3H3COCH3CHOOOOHONCH3CH3CH3