血管祖细胞在动脉粥样硬化发病中的作用

1、烦恼有何惧怕，既然躲不掉，就调好心态与它共存。心向阳光，何惧风霜。茫茫人海你我相遇就是缘分，欢迎下载！2021/4/262血管祖细胞在动脉粥样硬化发病中的作用血管祖细胞在动脉粥样硬化发病中的作用Vascular Progenitor Cells Contribute to Pathogenesis of Atherosclerosis 2021/4/263nAccumulation of smooth muscle cells (SMCs) plays a principal role in atherogenesisnIt generally is believed that neointi

2、mal SMCs in vascular lesions originate locally from SMCs of the medial layer. nHowever, several phenomena could not be explained by this hypothesis.preface2021/4/264nVery few articles have documented SMCs migrating across the internal elastic lamina from the media into the subendothelial layer. Bloo

3、d cells attach to the luminal side of the injured artery prior to the development of neointimal hyperplasia.nNeointima could be formed in the absence of medial cells.2021/4/265nSMC hyperplasia could be prevented by blocking chemokines or adhesion molecules, which play a crucial role in recruiting bl

4、ood cells but have no effect on migration and proliferation of differentiated SMCs.nNeointimal SMCs are quite distinct from medial SMCs in phenotype and gene expression patterns.2021/4/266Some of the SMC-like cells in vascular lesions are derived from blood cells rather than from medial cells.Hypoth

5、esis2021/4/267Express various markers for SMCs心脏移植心脏移植2021/4/268These results indicatedthat the majority of the neointimalcells derived from the recipient cells,but not from the medial cells of donor origin.源于受者细胞源于受者细胞2021/4/269骨髓移植骨髓移植These results indicatedthat bone marrow cells give rise to vasc

6、ularcells, thereby contributing to arterialremodeling after mechanical injury.源于骨髓细胞源于骨髓细胞2021/4/2610These results indicate that bone marrow cells give rise to SMC-like cells observed in hyperlipidemia-induced atherosclerotic plaques.高脂致高脂致AS斑块中斑块中SMC样细胞源于骨髓样细胞源于骨髓2021/4/2611骨髓多能细胞骨髓多能细胞（Pluripotent

7、 cells）造血干细胞造血干细胞（hematopoietic stem cells ，HSCs)间叶干细胞间叶干细胞（mesenchymal stem cells）n9、 人的价值，在招收诱惑的一瞬间被决定。2022-3-232022-3-23Wednesday, March 23, 2022n10、低头要有勇气，抬头要有低气。2022-3-232022-3-232022-3-233/23/2022 9:16:49 PMn11、人总是珍惜为得到。2022-3-232022-3-232022-3-23Mar-2223-Mar-22n12、人乱于心，不宽余请。2022-3-232022-3-23

8、2022-3-23Wednesday, March 23, 2022n13、生气是拿别人做错的事来惩罚自己。2022-3-232022-3-232022-3-232022-3-233/23/2022n14、抱最大的希望，作最大的努力。2022年3月23日星期三2022-3-232022-3-232022-3-23n15、一个人炫耀什么，说明他内心缺少什么。2022年3月2022-3-232022-3-232022-3-233/23/2022n16、业余生活要有意义，不要越轨。2022-3-232022-3-23March 23, 2022n17、一个人即使已登上顶峰，也仍要自强不息。2022-

9、3-232022-3-232022-3-232022-3-232021/4/2613HSC (c-Kit, Sca-1, Lin) was isolated from the bone marrow of LacZ mice 3,000 cells were injected into lethally irradiated wild-type mice (LacZ) -. Four weeks after bone marrow reconstitution, the femoral arteries of the recipient mice were injured mechanical

10、ly At 4 weeks, the injured arteries showed neointimal hyperplasia.The neointima and the media contained many LacZ-positive cells. Some LacZ positive cells expressed -SMA. Some LacZ positive cells expressed CD31.2021/4/2614These findings indicate that the c-Kit, Sca-1,Lin fraction of bone marrow cell

11、s has the potential to differentiate into either SMCs or ECs, thereby contributing to vascular remodeling.血管祖细胞血管祖细胞造血干细胞造血干细胞血管重塑血管重塑Smooth muscle progenitor cells Endothelial progenitor cell2021/4/2615治疗靶点治疗靶点2021/4/2616n内皮祖细胞参与出生后的血管发生和缺内皮祖细胞参与出生后的血管发生和缺血组织的血管新生，参与损伤血管内皮血组织的血管新生，参与损伤血管内皮的修复。的修复。

12、n血管内皮损伤是血管内皮损伤是ASAS发生的始动因素。冠发生的始动因素。冠心病患者外周血内皮祖细胞的数量减少，心病患者外周血内皮祖细胞的数量减少，功能减退。功能减退。n内皮祖细胞有可能通过对损伤血管内皮内皮祖细胞有可能通过对损伤血管内皮的修复，抑制的修复，抑制ASAS的发生。的发生。 2021/4/2617谢谢！谢谢！2021/4/2618n9、 人的价值，在招收诱惑的一瞬间被决定。2022-3-232022-3-23Wednesday, March 23, 2022n10、低头要有勇气，抬头要有低气。2022-3-232022-3-232022-3-233/23/2022 9:16:50 PMn11、人总是珍惜为得到。2022-3-232022-3-232022-3-23Mar-2223-Mar-22n12、人乱于心，不宽余请。2022-3-232022-3-232022-3-23Wednesday, March 23, 2022n13、生气是拿别人做错的事来惩罚自己。2022-3-232022-3-232022-3-232022-3-233/23/2022n14、抱最大的希望，作最大的努力。2022年3月23日星期三2022-3-2