壳聚糖论文：壳聚糖的改性研究

1、壳聚糖论文：壳聚糖的改性研究【中文摘要】本论文首先利用甲氧基聚乙二醇(mPEG)改善壳聚糖的水溶性。将不同分子量的mPEG的羟基羧化后,与壳聚糖分子链上3位羟基发生酯化反应,制备出梳形可分散于水的甲氧基聚乙二醇接枝壳聚糖(CS-g-mPEG)。采用红外光谱(IR)、核磁共振(1H-NMR)对CS-g-mPEG的结构进行了表征,结果表明这种方法可以成功制备CS-g-mPEG。接枝共聚物水溶性实验表明,CS-g-mPEG接枝共聚物的溶解性得到显著提高。为了改善壳聚糖的脂溶性,本论文在壳聚糖上面引入聚乳酸,壳聚糖上的羟基引发丙交酯开环聚合得到壳聚糖-聚乳酸(CS-g-PLA)接枝共聚物。采用红外光谱

2、(IR)和核磁共振(1H-NMR)表征了接枝共聚物的结构。共聚物的脂溶性实验表明,壳聚糖接枝聚乳酸后可以溶解在部分有机溶剂中。另外,本文还利用胺解技术在聚乳酸膜表面引入自由氨基,再利用戊二醛将氨基转化为自由醛基,然后用壳聚糖涂层的方法,制备了壳聚糖表面改性的聚乳酸膜载体。采用红外光谱(IR)对改性聚乳酸膜的结构进行分析表征。结果表明,壳聚糖可以成功固定在聚乳酸膜表面。壳聚糖接枝聚乳酸膜表面后可以改善聚乳酸的生物相容性。【英文摘要】Firstly, water solubility of the chitosan was improved by methoxy poly(ethylene gly

3、col)(mPEG) in this paper. mPEG with different molecular weights after carboxylated was occurred esterification reaction to the hydroxyl groups at C-3on the chitosan backbone, and the comb-shaped methoxypoly(ethylene glycol) grafted chitosan(CS-g-mPEG) which can be dispersed in water was prepared. Th

4、e structure of CS-g-mPEG was characterized by infrared spectroscopy (IR) and nuclear magnetic resonance(H-NMR), and the results showed that CS-g-mPEG can be successfully prepared by this method.Water-soluble experiment of the graft copolymer showed that the solubility of the CS-g-mPEG graft copolyme

5、r was improved significantly.polylactide(PLA) was introduced to chitosan, and the graft copolymer of chitosan-g-polylactide(CS-g-PLA) was synthesized successfully through ringopeningpolymerization by the hydroxyl group of the chitosan initiated, in order to improve fat solubility. The structure of t

6、his graft copolymer was characterized by IR and 1H-NMR. Fat-soluble experiment of the copolymer showed that chitosan grafted PLA can dissolve in partial organic solvents.In addition, in this paper, the free amino was introducd to the surface of the PLA membrane by using aminolysis technique, and ami

7、no group was transformed into adehyde group by using glutaraldehyde, then chitosan-modified PLA membrane was fabricated bychitosan-coating technique. The structure of the modified PLA was characterized by IR. The results showed that chitosan canbe successfully fixed in the surface of the polylactide

8、 membrane. The biocompatibility of PLA can be improved after chitosan grafted the surface of PLA membrane.【关键词】壳聚糖 接枝共聚物 甲氧基聚乙二醇 聚乳酸 丙交酯 【英文关键词】chitosan graft copolymer phthaloylchitosan poly(ethylene glycol)(mPEG) polylactide(PLA) Lactide【目录】壳聚糖的改性研究4-5ABSTRACT5摘要1.1 壳聚糖1.2.1 壳聚糖在生第一章 绪论8-18的简介8-91

9、.2 壳聚糖的应用9-11物医用材料方面的应用9-10应用101.2.2 壳聚糖在食品工业方面的1.2.41.2.3 壳聚糖在造纸工业方面的应用10壳聚糖在纺织工业方面的应用10方面的应用10-11111212-1313-14反应15161.2.5 壳聚糖在吸附和螯合1.2.6 壳聚糖在环保方面的应用1.3.1 主链降解1.3.3 酯化反应1.3.5 酰化反应1.3.7 希夫碱1.3.9 共混改性第二章1.3 壳聚糖的改性11-161.3.2 烷基化反应121.3.4 醚化反应131.3.6 壳聚糖的接枝改性14-151.3.8 羧基化反应15-161.4 研究目的和意义及主要研究内容16-1

10、82.1 引言18-19mPEG-g-CS的制备18-2819-222.2 实验部分2.2.1 实验药品及试剂192.2.2 实验仪器19-2020-2222-272.2.3 mPEG-g-CS的接枝共聚物的制备2.2.4 mPEG-g-CS的表征222.3.1 PHCS的结构表征22-242.3 结果与讨论2.3.2 mPEG-COOH2.3.4 聚第三章 3.2的表征24-25合物溶解性能实验2.3.3 mPEG-g-CS的表征25-2626-272.4 本章小结27-283.1 引言28-29壳聚糖接枝聚乳酸共聚物28-38实验部分29-3229-30323.2.1 实验药品和仪器、实验

11、药品干燥处理3.3 PLA-g-CS的表征3.3.2 核磁共3.2.3 实验方法30-323.3.1 傅里叶红外光谱(IR)测试32振波谱(NMR)分析323232-333.3.3 聚合物的溶解性能实验3.4.1 PHCS的结构表征3.4.3 PLA-g-CS3.4 结果与讨论32-373.4.2 PLA-g-PHCS的表征33-35的结构表征35-3636-373.4.4 聚合物的溶解性能实验第四章 壳聚糖涂层聚乳酸4.2 聚乳酸膜的制备及其4.3.1 实验药品及试4.4 实验方法4.4.2 聚乳酸的改性4.5.1 红外光谱仪4.6 结果与讨4.6.2 醛3.5 本章小结37-384.1 引言384.3 实验部分40-41膜的制备38-47改性38-40剂4041-4241-424.3.2 实验仪器40-414.4.1 PLA膜