谁在承担未成熟大鼠海马神经元及突触损伤的保护责任？

1、SICENCE新闻发布 作者：周戬平 稿号：NRR_1_14 谁在承担未成熟大鼠海马神经元及突触损伤的保护责任？1,6-二磷酸果糖是一种促进细胞代谢的中间物，对大脑皮质神经元有保护作用，但其能否减轻反复热性惊厥导致的海马神经元及突触损伤？来自中国西安交通大学第二附属医院周戬平所在团队选择相当于人类3-5岁的21日龄未成熟大鼠构建反复热性惊厥大鼠模型，按100 mg/100 g剂量将1,6-二磷酸果糖腹腔注射于模型大鼠，发现其海马CA1区线粒体肿胀、粗面内质网脱颗粒以及高尔基体扩张，能显著缩小突触间隙宽度，增加突触活性带长度及突触后致密区厚度及突触界面曲率。结果提示1,6-二磷酸果糖对反复热性惊

2、厥引起未成熟大鼠海马神经元及突触损伤有保护效应。文章发表在中国神经再生研究（英文版）杂志2014年5月第9期。透射电镜下可见，100 mg/100 g 1,6-二磷酸果糖腹腔注射可减轻反复热性惊厥模型未成熟大鼠海马CA1区粗面内质网脱颗粒（箭头）Article: Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage inimmature rats: neuroprotective effect of fructose-1,6-diphosphate, by Jianping Zhou1

3、, Fan Wang2, Jun Zhang3, Hui Gao4, Yufeng Yang5, Rongguo Fu6 (1 Department of Pediatrics, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, Xian, Shaanxi Province, China; 2 Department of Obstetrics and Gynecology, Shaanxi Provincial Peoples Hospital, Xian, Shaanxi Province

4、, China; 3 Department of Gastroenterology, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, Xian, Shaanxi Province, China; 4 Department of Anesthesiology, Yanan University Affiliated Hospital, Yanan, Shaanxi Province, China; 5 Editorial Board of Chinese Journal of Child H

5、ealth Care, Xian, Shaanxi Province, China; 6 Department of Nephrology, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, Xian, Shaanxi Province, China)Zhou JP, Wang F, Zhang J, Gao H, Yang YF, Fu RG. Repeated febrile convulsions impair hippocampal neurons and cause synapti

6、c damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate. Neural Regen Res. 2014;9(9):937-942.欲获更多资讯：SICENCE新闻发布 作者：周戬平 稿号：NRR_1_14Who are responsible for protecting against neuron and synapse injury in immature rats?Fructose-1,6-diphosphate is a metabolic intermediate that prom

7、otes cell metabolism. Whether it can alleviate hippocampal neuronal injury caused by febrile convulsion remains unclear. Dr. Jianping Zhou, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, China and his team established a repetitive febrile convulsion model in rats aged 2

8、1 days, equivalent to 35 years in humans, intraperitoneally administered fructose-1,6-diphosphate at 1,000 mg/kg into the rat model. Results showed that high-dose fructose-1,6-diphosphate reduced mitochondrial swelling, rough endoplasmic reticulum degranulation, Golgi dilation and synaptic cleft siz

9、e, and increased synaptic active zone length, postsynaptic density thickness, and synaptic interface curvature in the hippocampal CA1 area. The present findings suggest that fructose-1,6-diphosphate is a neuroprotectant against hippocampal neuron and synapse damage induced by repeated febrile convul

10、sion in immature rats. These results were published in NeuralRegeneration Research (Vol. 9, No. 9, 2014).Through transmission electron microscopy, it is known that fructose-1,6-diphosphate at 1,000 mg/kg administered intraperitoneally can alleviate rough endoplasmic reticulum degranulation (arrow) i

11、n hippocampal CA1 region of rats with repeated febrile convulsions.Article: Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate, by Jianping Zhou1, Fan Wang2, Jun Zhang3, Hui Gao4, Yufeng Yang5, Ronggu

12、o Fu6 (1 Department of Pediatrics, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, Xian, Shaanxi Province, China; 2 Department of Obstetrics and Gynecology, Shaanxi Provincial Peoples Hospital, Xian, Shaanxi Province, China; 3 Department of Gastroenterology, the Second A

13、ffiliated Hospital, Medical College of Xian Jiaotong University, Xian, Shaanxi Province, China; 4 Department of Anesthesiology, Yanan University Affiliated Hospital, Yanan, Shaanxi Province, China; 5 Editorial Board of Chinese Journal of Child Health Care, Xian, Shaanxi Province, China; 6 Department of Nephrology, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, Xian, Shaanxi Province, China)Zhou JP, Wang F, Zhang J