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1、Neuroprotective Effects of Lutein in the RetinaYoko Ozawa1,2Yoko Ozawa1,2* *, Mariko Sasaki1,2, Noriko Takahashi1,2, , Mariko Sasaki1,2, Noriko Takahashi1,2, Mamoru Kamoshita1,2, Seiji Miyake1 and Kazuo Tsubota2Mamoru Kamoshita1,2, Seiji Miyake1 and Kazuo Tsubota21 1视网膜细胞生物学重点实验室视网膜细胞生物学重点实验室2 2眼科系，

2、庆应义塾大学医学院，眼科系，庆应义塾大学医学院，3535信浓町，信浓町，ShinjukukuShinjukuku，东京，东京160-8582160-8582，日本，日本Current Pharmaceutical Design （当今制药杂志）当今制药杂志） NLM NLM 缩写：缩写：CurrCurr PharmPharm Des DesNLM IDNLM ID：9602487 9602487 出版国家：出版国家：NetherlandsNetherlands出版地：出版地：SchipholSchiphol, The Netherlands, The Netherlands出版商：出版商：Be

3、ntham Science PublishersBentham Science Publishers出版周期：出版周期：Twenty-eight no. a year,Twenty-eight no. a year,创刊年份：创刊年份：19951995语言：语言：英语英语 SCISCI收录：收录：YES YES 研究领域：研究领域：药物设计、医药技术药物设计、医药技术ISSNISSN：1381-6128 (1381-6128 (印刷版印刷版) ) 1873-4286 (1873-4286 (电子版电子版) ) 1381-6128 (1381-6128 (ISSNLinkingISSNLinki

4、ng) ) 目前收录于：目前收录于：IMIMPubMedPubMed收录：收录：YES YES 影响因子影响因子投稿情况投稿情况同类期刊排行同类期刊排行排行排行杂志杂志1 1Nature reviews. Drug discoveryNature reviews. Drug discovery2 2Annual review of pharmacology and toxicologyAnnual review of pharmacology and toxicology3 3Pharmacological reviewsPharmacological reviews4 4Advanced d

5、rug delivery reviewsAdvanced drug delivery reviews5 5Trends in pharmacological sciencesTrends in pharmacological sciences6 6Medicinal research reviewsMedicinal research reviews7 7Drug resistance updates : reviews and commentaries in antimicrobial Drug resistance updates : reviews and commentaries in

6、 antimicrobial and anticancer chemotherapyand anticancer chemotherapy8 8Pharmacology & therapeuticsPharmacology & therapeutics9 9NeuropsychopharmacologyNeuropsychopharmacology : official publication of the American College : official publication of the American College of of Neuropsychopharm

7、acologyNeuropsychopharmacology1010Current opinion in pharmacologyCurrent opinion in pharmacology该杂志在PHARMACOLOGY & PHARMACY (药学)同类期刊中的影响因子排名第47位Contents简介简介1、叶黄素的相关资料、叶黄素的相关资料2、临床研究结果、临床研究结果 3叶黄素在小鼠视网膜疾病模型中的叶黄素在小鼠视网膜疾病模型中的生物效应和潜在分子机制生物效应和潜在分子机制 4、结论、结论 简介：简介： Content Title Content Title Content

8、Title Description of the contents Description of the contents 植物化学物质是植物衍生的化合物，是人体非必需的营养物质。因为他们植物化学物质是植物衍生的化合物，是人体非必需的营养物质。因为他们往往有色素、香味或有苦味，他们被认为可以起到一定的保护作用来抵御外来往往有色素、香味或有苦味，他们被认为可以起到一定的保护作用来抵御外来威胁，如紫外线、病原体和植物为食的生物。类胡萝卜素的基本结构为威胁，如紫外线、病原体和植物为食的生物。类胡萝卜素的基本结构为C C 4040 H H 5656。这些化合物是抗氧化剂，它们有多个双键，可以抗氧化清除

9、活性氧。这些化合物是抗氧化剂，它们有多个双键，可以抗氧化清除活性氧自由基（自由基（ROSROS）。虽然类胡萝卜素仅由碳和氢组成，但是叶黄素还包括其他元）。虽然类胡萝卜素仅由碳和氢组成，但是叶黄素还包括其他元素。叶黄素分子式为（素。叶黄素分子式为（C C 40 H40 H 5656 O O 2 2）（图）（图1 1）。叶黄素的性能与其它类胡萝卜）。叶黄素的性能与其它类胡萝卜素有很大不同。素有很大不同。胡萝卜素在体内转化为维生素胡萝卜素在体内转化为维生素A A，因此被称为维生素，因此被称为维生素A A前体前体 。叶黄素是一种黄。叶黄素是一种黄色晶体，在一些蔬菜中发现，如甘蓝，菠菜，西兰花，也有万寿

10、菊花，从中可色晶体，在一些蔬菜中发现，如甘蓝，菠菜，西兰花，也有万寿菊花，从中可以补充微量营养素。以补充微量营养素。简介：简介：因为动物不能合成叶黄素，它们必须从饮食中获得。从肠上皮细胞吸因为动物不能合成叶黄素，它们必须从饮食中获得。从肠上皮细胞吸收入血，经过全身循环到达肝脏、肺和视网膜细胞。在人的视网膜上，收入血，经过全身循环到达肝脏、肺和视网膜细胞。在人的视网膜上，它集中在最中心的区域它集中在最中心的区域- -黄斑区（图黄斑区（图2A2A，B B），因此被称为黄斑色素。），因此被称为黄斑色素。此黄斑色素结构显示两个具有相同属性的立体异构体，分别为叶黄素此黄斑色素结构显示两个具有相同属性的立

11、体异构体，分别为叶黄素和玉米黄质。每个组织的这些异构体的比例是不同的（和玉米黄质。每个组织的这些异构体的比例是不同的（例如，例如，视网膜视网膜和血浆之间），这表明它们是内部之间的转化。本研究还表明，这种和血浆之间），这表明它们是内部之间的转化。本研究还表明，这种转化（转化（3R3R，30R30R，60R60R）- -叶黄素叶黄素非饮食代谢产物（非饮食代谢产物（3R3R，30S-30S-内消旋内消旋的），玉米黄质的），玉米黄质（3R3R，30R30R）- -玉米黄质通过一系列的氧化还原和双玉米黄质通过一系列的氧化还原和双键异构化反应代谢的。键异构化反应代谢的。 DiagramRealityIde

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