血脂相关指标及动脉粥样硬化发展阶段相关性探究

1、血脂相关指标及动脉粥样硬化发展阶段相关性探究【摘要】目的通过检测动脉粥样硬化(as)不同发展阶段 的各种血脂相关指标，来探讨各种检测值与as各个发展阶段的相关性。方法随机选择健康体检者60例(as()组x脑 as无并发症患者24例(as(+)组x as性脑栓塞患者67例 (as(+)组),酶化学法测定血清三酰甘油(tg x总胆固醇 (tc),直接法测定低密度脂蛋白胆固醇(ldlc 高密度 脂蛋白胆固醇(hdlc ),免疫透射比浊法测定载脂蛋白ai (apoal 载脂蛋白 b100( apob100、脂蛋白(a )(lp(a), 并对3组的检测值进行统计分析。结果as(+)组与as()组 比较，

2、tg、tc、ldlc、apobioo. lp(a)、apob100/apoai 增高(pa和+83 bp c->t，在apoal基因中作上述碱基 替代，可抑制apoal基因的转录和表达。这可解释，包含-75 bp a和+83 bp t的个体为什么具有较低的hdlc水平。本调查结果提示,tg、tc、ldlc、hdlc、apoal、 apobioo. lp(a)、apob100/apoai 水平与 as 的早期发展 阶段相关，而且 apobioo. lp(a)、apob100/apoai 水平与 as的晚期发展阶段相关。因此，较之于其它血脂相关指标， apobioo. lp(a)和apob1

3、00/apoai更可靠,可作为诊断 as发生发展的辅助指标，也可作为检测各种措施对as治疗 效果的参考指标。参考文献口itiyyagura sr, smith da. standard lipid profile. clin lab med, 2006,26:707732口2zabalawi m, bharadwaj m, horton h, et al. inflammation and skin cholesterol in ldlr-/-, apoa-l-/- mice: link between cholesterol homeostasis and self-tolerance? j

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