解热镇痛药PPT课件

1、A Free sample background from Slide 1A Free sample background from Slide 2A Free sample background from Slide 3OCOOHCH3OHOCOOHCH3OHOHOCOOHCH3OHHOHOCOOHCH3 OHHOOPGH2PGE2PGF2PGD2PG endoperoxide reductasePG endoperoxide E isomeraseglutathione-S-transferasePG peroxidaseA Free sample background from Slid

2、e 4A Free sample background from Slide 5A Free sample background from Slide 6PGH2OCOOHCH3OHOCOOHCH3OHOHOHOTXA2TXB2COOHCH3 OHHOHOOCH3OHHOOCOOHPGI26-keto PGF1prostacyclinsynthetasethromboxanesynthetaseCOOHCH3OHOOA Free sample background from Slide 7A Free sample background from Slide 8A Free sample ba

3、ckground from Slide 9A Free sample background from Slide 10COOHCH3AACell membrane phospholipidsPhospholipase A212-HPETE12-HETECOOHCH3OOH5-HPETE12-lipoxygenase5-lipoxygenaseLTA synthetaseCH3COOHOHCOOHCH3OOHA Free sample background from Slide 11dipeptidaseglutathione-StransferaseCOOHC5H11OHSCOOHNHH2NO

4、HOOCCOOHC5H11OHSH2NCOOHCOOHC5H11OHSNHCOOHOH2NLTA hydrolaseCOOHC5H11OHSNHCOOHONHH2NOHOOCLTF4LTE4LTD4LTC4LTB4LTA4COOHCH3OHOHCOOHCH3O-glutamyl transpeptidase-glutamyltranspeptidaseA Free sample background from Slide 12A Free sample background from Slide 13A Free sample background from Slide 14A Free sa

5、mple background from Slide 15A Free sample background from Slide 16A Free sample background from Slide 17CH3NHOH3COCH3NHOAcetanilidePhenacetinA Free sample background from Slide 18N-(4-羟基苯基羟基苯基)乙酰胺乙酰胺N-(4-Hydroxyphenyl)acetamide醋氨酚（醋氨酚（Acetaminophen）扑热息痛）扑热息痛CH3NHOHOA Free sample background from Sli

6、de 19A Free sample background from Slide 20GluNCH3HOOHNCH3HOOOHNCH3OOHNCH3OOSHOOOHNCH3OHNCH3OOH3CHNH2OH3CGlucuronidesulfatephenacetinAcetanilidehepatotoxicmethmoglobinemia,hemolytic anemiaA Free sample background from Slide 21glutathioneNCH3OONCH3HOOglutathineHN-acetylimidoquinone reactive metabolit

7、e hepaticproteinsNCH3HOOHhepaticproteinsNCH3HOOSHOOHNCH3OHN-acetylcysteinhepatic necrosisrenal failure rena l e x cretion as mercapturic acid o r cy steine conjuga t esA Free sample background from Slide 22A Free sample background from Slide 23A Free sample background from Slide 24COOHOHCOOHOCH3CONH

8、2OHOA Free sample background from Slide 25A Free sample background from Slide 26OHOOCOCH3COONHCOCH3FFOHOHOOCOOH在水杨酸的在水杨酸的5-位引入芳香环，可以增加其抗位引入芳香环，可以增加其抗炎活性，例如，引入二氟苯基得到二氟尼柳炎活性，例如，引入二氟苯基得到二氟尼柳（Diflunisal）,其抗炎和镇痛活性均比阿司其抗炎和镇痛活性均比阿司匹林强匹林强4倍，体内的维持时间长达倍，体内的维持时间长达812h，胃，胃肠道的刺激性小，可用于关节炎，手术后或肠道的刺激性小，可用于关节炎，手术后或癌

9、症引发的疼痛的治疗。癌症引发的疼痛的治疗。A Free sample background from Slide 27A Free sample background from Slide 28COO-OCOCH3COO-OH. (CH3)3N+CH2CH2OHCOO-OCOCH3. H3N+CH(CH2)4N+H32AlOHCOO-阿司匹林阿司匹林 AspirinOOHOCH3OA Free sample background from Slide 29OHOHO+H3COOCH3OH2SO47075OOHOOCH3A Free sample background from Slide 30

10、COOHOCOCH3+(CH3CO)2OOCOCH3OOCOCH3OOOCH3OOCH3OOOA Free sample background from Slide 31OHOH+Fe3+OOOHOFe3+OHOHOOHOHOHOOHOOOOHOHOHOHOOHOOOHOOHO或HOO-OO+OHOO黄色蓝至黑色A Free sample background from Slide 32OOHOCH3OOHOHOCOOHOGluOOGluOHNHCH2COOHOOHOHOHHOOHOOHOOHOHNHCH2COOHOOHHOOHOOHHOUDP-葡萄糖醛酸转移酶UDP-葡萄糖醛酸转移酶甘氨酸N-酰基转移酶甘氨酸N-酰基转移酶龙胆酸SAA Free sample background from Slide 33A Free sample background from Slide 34A Free sample background fr