味精安全问题PPT课件

1、skeletal stunting骨萎缩骨萎缩marked obesity明显肥胖明显肥胖sterility 不育不育hypothalamic lesions下丘脑损伤下丘脑损伤msg injected注射味精后注射味精后olney jw. science 164: 719-721, 1969.小白鼠注射味精后出现大脑损小白鼠注射味精后出现大脑损伤，肥胖以及其他系统紊乱伤，肥胖以及其他系统紊乱1969年科学杂志年科学杂志adult males (80 kg) quickly ingested msg, 12.7 g (150 mg/kg) in solution.成年男子 （体重约80公斤）能

2、很快吸收溶液中12.7g（约150毫克每公斤）的味精time (minutes)060120180240plasma glu (nmol/ml)100200300400500arrows = meal or snack 箭头代表摄取的食物或点心meals: 0745, 1215, 1800 h 饮食时间：0745，1215，1800data are means sem(n = 10)数据：均值标准差black circle: no msg黑圈表示不含味精white circle: msg.白圈表示含有味精time (minutes)060120180240plasma prolactin (n

3、g/ml)510152025trh placebomsgprotein mealstegink ld et al am j obstet gynecol 122: 70-78 (1975)monkey study.猴子实验猴子实验highest dose (400 mg/kg iv, open circles) produced plasma glu 70-times normal.battaglia fc. j nutrition 130: 974s-977s (2000)lactating women ingested 100 mg/kg msg in capsules with wate

4、r, and milk samples were taken at the indicated times thereafter. from: baker gl et al., factors influencing dicarboxylic amino acid content of human milk. in: , filer lj et al., ed. new york, raven press, 1979 , pp. 111-123.哺乳期女性加水摄入 100 mg/kg 的胶囊，对其后特定时间的母乳样品进行检验表明：这一剂量使得血液谷氨酸浓度在这一剂量使得血液谷氨酸浓度在30-4

5、5分钟内从分钟内从 from: baker gl et al., factors influencing dicarboxylic amino acid content of human milk. in: , filer lj et al., ed. new york, raven press, 1979 , pp. 111-123.影响人体母乳二氨基酸浓度的因素谷氨酸：生物化学和生理学进展nprotocol a: self-styled msg-sensitive individuals. fasted, challenge with placebo or msg (5 g in liqu

6、id).n实验a：130例自认为msg过敏者，禁食，以安慰剂或msg(5克液体)进行盲试。nprotocol b:subjects had positive response of 2 symptoms toeither or both treatments in a (i.e., placebo responderstoo). fast, challenge with 0, 1.25, 2.5 or 5 gmsg (in liquid).n实验b: 对a中，出现阳性反应的实验对象，超过2种症状（例如：对安慰剂反应也一样）。禁食，以0，1.25，2.5或5克msg(液体)进行盲试。geha r

7、s et al., j allergy clin immunol 106:973-80, 2000nprotocol c:subjects had positive response of 2 symptoms to 5g msg but not placebo in a or b. fast, placebo (suc- rose) or msg (5 g), in capsules (). do twice.n实验实验c: 对a和b中阳性反应的实验对象-对5克msg出现超过2种症状（对安慰剂没有），禁食，以胶囊性的安慰剂（蔗糖）或msg(5克)，进行盲试。重复实验。nprotocol d:

8、subjects had positive response to both msg chal-lenges in c. fast, breakfast & placebo (sucrose)or msg (5 g), in capsules (). do three times.n实验实验d: 对c中msg治疗出现阳性反应的实验对象，禁食，早餐加胶囊性安慰剂（蔗糖）或msg(5克)，进行盲试。重复3次实验geha rs et al., j allergy clin immunol 106:973-80, 2000geha rs et al., j allergy clin immunol 1

9、06:973-80, 2000 placebo.: geha rs et al., j allergy clin immunol 106:973-80, 2000geha rs et al., j allergy clin immunol 106:973-80, 2000geha rs et al., j allergy clin immunol 106:973-80, 2000geha rs et al., j allergy clin immunol 106:973-80, 2000geha rs et al., j allergy clin immunol 106:973-80, 200

10、0conclusion: using criteria established by the 1995 faseb panel, none of the individuals who claimed a sensitivity to msg actually showed this sensitivity when tested under blinded conditions.结论：根据1995年美国实验生物学联合会（faseb）制定的标准，对那些声称味精过敏的个体进行双盲试验表明他们未表现出敏感性。stevenson dd. monosodium glutamate and asthma

11、. j nutr 130: 1067s-1073s, 2000味精和哮喘 2000年 营养学杂志.simon ra. additive-induced urticaria: experience with monosodium glutamate (msg).j nutr 130: 1063s-1066s, 2000. bazzano g, delia ja, olson re science 169: 1208-1209, 1970.adult human subjects ingested a chemically-de-fined diet supplying all of the essential amino acids in optimum amounts, plus glutamic acid as the sole source of non-essential nitrogen, for 14-42 days. no subjects developed