世界最杰出的生物医学论文

1、.世界最杰出的生物医学论文 千名生物学家（Faculty of 1000 Biology）和千名医学家（Faculty of 1000 Medicine）是英国BioMed Central出版集团，所建立的两个医学生物学论文数据库。它是由美国哈佛大学和英国剑桥大学等近5000多名世界顶级生物医学同行专家，所推荐和评选出的世界医学和生物学的最新发表的论文所组成。论文依据创新性、新理论、新发现、新技术、科学价值和实际应用前景等原则，从世界上几千种重要的医学生物学杂志，成千上万篇论文中，实时进行筛选和评定，评选出F1000因子，并进行分级排序，分为杰出(Exceptional 9分)、必读(Must

2、 Read 6分)和推荐(Recommend 3分)三个级别，并写有简短的评语。再向医学生物学界进行推荐和发布，以提供世界上最重要、最优秀的生物医学论文信息和最新研究成果与发展趋势。 F1000只重视论文的实际科学价值和临床应用前景，不考虑期刊的状况和论文在何处发表，影响因子（I F）值也仅仅作为辅助参考指标。被推荐出的论文不足SCI发表论文的千分之二，其中杰出的论文仅占所推荐论文的5%。F1000还依据不同的科学领域，适时评选出最近和最受关注（Must-Viewed）的10篇最佳论文，称为“Top 10”，并不断更新。此外还邀请世界上最知名和权威的领域科学家，编写生物医学最近的进展、评论和综

3、述，刊登在“F1000 Reports上”。 F1000是一个新的医学生物学论文数据库，是一个新的生物医学论文评价工具，是一个新的医学论文评估的专家系统。它不仅可以帮助我们来快速检索世界上最“杰出”、“必须阅读”和“值得推荐”的生物医学论文；还可以了解每篇发表论文的专家评价观点和意见，使我们可以节时、高效、全面认识和了解当今世界上生物医学最新研究成果和发展动向，引导和促进生物医学科学的发展。研究论文能为F1000所收录和推荐，成为F1000“杰出”论文，代表着该论文的极高的科学水平和重要的科学价值。 目前我国每年被SCI收录的医学生物学论文已逾万篇，成为“论文大国”，但能为F1000收录为“杰

4、出”的论文却寥寥。以20092010年为例，在F1000收录和推荐出1017篇“杰出”论文中，中国只有11篇，其中还有4篇是台湾和香港的。从20002010年F1000共评出近5000篇“杰出”论文，中国（包括台湾和香港）总共只有25有篇。反应出我国现在医学生物学研究“跟”多“创”少，重“量”不重“质” ；一般资料性的工作多，有创新性、有实际应用价值、有重要理论和应用前景的论文少的潜在而深刻的危机。我们必须在原始创新和实际应用上再上一层楼！我们要发表SCI论文，要发表高IF影响因子论文；我们更要多发表F1000“杰出”论文，发表创新性强，有重要理论价值和实际应用前景的科学论文，这才能成为真正的

5、科技强国。 这里我们收集了20092010年心血管、肿瘤、细胞生物学、分子生物学、免疫学、神经科学等领域F1000的“杰出”论文供大家参考，更多的F1000论文，可在F1000Biology和F1000Medicine网站上搜索。 Biochemistry Bioinformatics Biotechnology Cancer Biology Cardiovascular Biology Cell Biology Chemical Biology Developmental Biology Ecology Evolutionary Biology Gastrointestinal Biolog

6、y Genomics & Genetics Immunology Metabolic & Endocrine Science Microbiology Molecular Biology Molecular Medicine Neuroscience Pharmacology & Drug Discovery Physiology Plant Biology Renal Biology Respiratory Biology Structural Biology Anesthesiology & Pain Management Cardiovascular Disorders Critical

7、 Care & Emergency Medicine Dermatology Diabetes & Endocrinology Gastroenterology & Hepatology Hematology Infectious Diseases Nephrology Neurological Disorders Oncology Otolaryngology Psychiatry Public Health & Epidemiology Research Methodology Respiratory Disorders Rheumatology & Clinical Immunology

8、 Urology Womens Health _F1000 Reportcell-A mover and a shaker- 53BP1 allows DNA doublestrand breaks a chance to dance and unite cell-A virtual cycle- theory and experiment converge on the exit from mitosis cell-Aberrant mRNA transcripts and nonsense-mediated decay cell-Autophagy of intracellular mic

9、robes and mitochondria- two sides of the same coin cell-Brd4 engagement from chromatin targeting to transcriptional regulation- selective contact with acetylated histone H3 and H4 cell-Conformational changes in receptor tyrosine kinase signaling- an ErbB garden of delights cell-Destroy to create- E3

10、 ubiquitin ligases in neurogenesis cell-Doing cell biology in embryos- regulated membrane traffic and its implications for cadherin biology cell-Epigenetic regulation of antigen receptor gene rearrangement cell-G-protein-coupled receptor structure cell-Induced pluripotent stem (iPS) cells- an up-to-

11、the-minute review cell-Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer cell-Intracellular trafficking and signaling in development cell-LOV conquers (sm)All GTPases cell-Membrane deformation and separation cell-Microtubule motors- moving forward on many fronts cell-

12、Mitochondria and apoptosis- a quick take on a long view cell-novel functions of the exocyst complex in polarized epithelia in animals cell-PARP inhibitors in BRCA1-BRCA2 germline mutation carriers with ovarian and breast cancer cell-Plk4-SAK-ZYG-1 in the regulation of centriole duplication cell-Puta

13、tive functions of caspase-2 cell-Recent advances in polyubiquitin chain recognition cell-Recent advances in understanding Golgi biogenesis cell-Regulatory roles of the cadherin superfamily cell-Role of caspases and non-caspase proteases in cell death cell-Roles of AD-cofilin in actin polymerization

14、and beyond cell-Roles of the small GTPases RhoA and Rac1 in cell behavior cell-Single-molecule dynamics of nuclear mRNA cell-Spindle checkpoint silencing- ensuring rapid and concerted anaphase onset cell-Telomeric RNAs as a novel player in telomeric integrity cell-The roles, mechanisms, and controve

15、rsies of autophagy in mammalian biology cell-Transport vesicle uncoating- its later than you think cell-Understanding lipid rafts and other related membrane domains cell-Vesicle coating and uncoating- controlling the formation of large COPII-coated carriers cell-When transcription meets recombinatio

16、n ecology-Characterizing changes in marine ecosystem services ecology-Climate change and biodiversity conservation- impacts, adaptation strategies and future research directions ecology-Current themes and recent advances in modelling species occurrences ecology-Eco-evolutionary dynamics- intertwinin

17、g ecological and evolutionary processes in contemporary time ecology-Evaluation of global change impacts on diffuse pollution ecology-Evolutionary impacts of fishing ecology-Extinction risks from climate change- macroecological and historical insights Ecology-Modelling ecosystem services in terrestr

18、ial systems ecology-The consequences of human-driven ocean acidification for marine life ecology-Toward understanding the effect of top predators on ecosystems genome-A direct measurement of crossing over in human prophase oocytes genome-Advances in the genetics of primary torsion dystonia genome-Ap

19、plications of high-throughput sequencing to chromatin structure and function in mammals genome-Bioinformatic detection of horizontally transferred DNA in bacterial genomes genome-CRISPR-Cas- an adaptive immunity system in prokaryotes genome-Distinct disorders affecting the brain share common genetic

20、 origins genome-Emerging technologies for the genomic analysis of cancer genome-Genetics of pulmonary arterial hypertension- do the molecular findings have translational value- genome-Hidden ribozymes in eukaryotic genome sequence genome-how medical sequencing and network biology will enable persona

21、lized medicine genome-Insulators- linking genome architecture to gene regulation genome-Mapping chromatin conformation genome-Pharmacogenetics of osteoporosis genome-PRDM9 sticks its zinc fingers into recombination hotspots and between species genome-Prediction of function in protein superfamilies g

22、enome-RecA-independent single-stranded DNA oligonucleotide-mediated mutagenesis genome-Recent advances in RNA sequence analysis genome-Retrotransposons and germ cells- reproduction, death, and diversity genome-The application of massively parallel sequencing technologies genome-Ubiquitous antisense

23、transcription in eukaryotes- novel regulatory mechanism or byproduct of opportunistic -NA polymerase genome-When transcription meets recombination- a lesson from the human RECQ protein complexes imm-Antigen processing for MHC presentation by autophagy imm-inf-A novel mucosal RORt+NKp46+ cell subset

24、is a source of interleukin-22 imm-inf-Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responses imm-inf-Alternative macrophage activation and the regulation of metabolism imm-inf-An update on pathobiologic roles of anti-glycan antibodies in Guillain-B

25、arr茅 syndrome imm-inf-B cell-targeted therapies in autoimmunity- rationale and progress imm-inf-Bacterial surface proteins and vaccines imm-inf-Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion imm-inf-Do apicomplexan parasites hijack the host cell

26、 microRNA pathway for their intracellular development imm-inf-Duality in the Th17-Treg developmental decision imm-inf-Electron transport chains of lactic acid bacteria - walking on crutches is part of their lifestyle imm-inf-Genetic reprogramming of host cells by bacterial pathogens imm-inf-Gut comm

27、ensal flora- tolerance and homeostasis imm-inf-HIV vaccination- turning the spotlight on effector memory T cells as mucosal gatekeepers imm-inf-HIV-1 host interactions- integration of large-scale datasets imm-inf-Latest advances in innate antiviral defence imm-inf-Lessons from the failure of the ade

28、novector HIV vaccine imm-inf-New templates for HIV-1 antibody-based vaccine design imm-inf-Ocular immune privilege imm-inf-Recent insights into fatty acid acquisition and metabolism in malarial parasites imm-inf-Recent strategies to identify broadly neutralizing antibodies against influenza A virus

29、imm-inf-Regulation of the IgE response imm-inf-The garden of antimicrobial delights imm-inf-The inflammasome and alum-mediated adjuvanticity imm-inf-The role of microbial polysaccharides in host-pathogen interaction imm-inf-Thymic egress- S1P of 1000 imm-inf-Two mechanisms that account for major his

30、tocompatibility complex restriction of T cells imm-inf-Why is Pseudomonas aeruginosa a pathogen imm-The role of IL-23 in the immunopathogenesis of psoriasis ns-A current view of Alzheimers disease ns-An uncorrelated state for the cortex ns-channelopathies- new antibody-mediated disorders of the cent

31、ral nervous system ns-Control of Schwann cell myelination ns-De novo prions ns-Development of object recognition in humans ns-Dysfunction of the CaV2.1 calcium channel in cerebellar ataxias ns-E3 ubiquitin ligases in neurogenesis ns-mechanotransduction in inner-ear hair cells ns-Multiple functions o

32、f dopamine neurons ns-Music drives brain plasticity ns-Neuronal calcium sensor proteins ns-Recent advances in neural development ns-Seeing with the minds eye ns-Setting the absolute threshold of vision ns-Sources of the spatial code within the hippocampus ns-The growth cone- an integrator of unique

33、cues into refined axon guidance ns-The posterior parietal cortex and non-spatial cognition ns-Transcranial magnetic stimulation studies of visuospatial attentional control ns-What drives corticospinal output ns-Why do oligodendrocyte lineage cells express glutamate receptors physiol-Functional body

34、composition- differentiating between benign and non-benign obesity physiol-Biased agonism physiol-Bitopic ligands- all-in-one orthosteric and allosteric physiol-Central control of feeding physiol-Depression and metabolism- linking changes in leptin and ghrelin to mood physiol-Malarial parasite patho

35、genesis and drug targets physiol-Multiple functions of dopamine neurons physiol-New antibiotics for antibiotic-resistant bacteria physiol-pharmacol-The pathophysiology of diastolic heart failure physiol-Purinergic cotransmission physiol-Regulation of the mTOR signaling pathway physiol-Role of neurop

36、eptides, hormones, and growth factors in regulating thymopoiesis in middle to old age physiol-Stress and eating behaviour physiol-Targeting cytokines in inflammatory diseases physiol-The ABCB1 transporter gene and antidepressant response physiol-The evolving story of orexin biology- the hits keep co

37、ming physiol-TRPV4 as a target for bladder overactivity physiol-Using the ribosome to synthesize peptidomimetics structural biology-Biased agonism structural biology-Describing protein conformational ensembles structural biology-Detailed mechanism for transposition by TnpA transposase involves DNA -

38、shape rather than direct protein-DNA recognition to generate an active nucleoprotein complex structural biology-Diversity of protein structures and difficulties in fold recognition-the curious case of protein G structural biology-Implications of the RecA structure structural biology-Mechanistic and

39、functional versatility of radical SAM enzymes structural biology-Membrane deformation and separation structural biology-Molecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules structural biology-Monte Carlo, harmonic approximation, a

40、nd coarse-graining approaches for enhanced sampling of biomolecular structure structural biology-Nuclear magnetic resonance captures the elusive structural biology-Osmolyte solutions and protein folding structural biology-protein conformation and the ubiquitination reaction cascade structural biolog

41、y-Recent advances in polyubiquitin chain recognition structural biology-RNA pseudoknots-folding and finding structural biology-Structure of spliceosomal ribonucleoproteins structural biology-The unforeseeable hammerhead ribozyme structural biology-Understanding lipid rafts and other related membrane

42、 domains structural biology-Unnatural amino acids- better than the real things F1000 Top 10bi-A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury bi-Cell line misidentification- the beginning of the end bi-Chaperonin-dependent accelerated substitution rates in

43、 prokaryotes bi-Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model bi-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis bi-High-resolution analysis of parent-of-origin allelic expression in the mouse brain bi-Long-timescale

44、molecular-dynamics simulations of the major urinary protein provide atomistic interpretations of the unusual thermodynamics of ligand binding bi-Mammalian microRNAs predominantly act to decrease target mRNA levels bi-Robust Growth of Escherichia coli bi-Sex-specific parent-of-origin allelic expressi

45、on in the mouse brain bi-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy bi-The genetic landscape of a cell biochem-Functional modules and structural basis of conformational coupling in mitochondrial complex I biochem-In Vivo Double

46、 and Triple Labeling of Proteins Using Synthetic Amino Acids biochem-One SNARE complex is sufficient for membrane fusion biochem-Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy biochem-Robust Growth of Escherichia coli biochem-Self-confirming AND logic nanoparticles for

47、fault-free MRI biochem-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy biochem-Structure of RCC1 chromatin factor bound to the nucleosome core particle biochem-Structure of the torque ring of the flagellar motor and the molecular ba

48、sis for rotational switching biochem-The architecture of respiratory complex I biochem-The functional capacity of the natural amino acids for molecular recognition biochem-Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans biology-Activation of beta-catenin in dendritic cells

49、regulates immunity versus tolerance in the intestine biology-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis biology-Astrocytes control breathing through pH-dependent release of ATP biology-Chaperonin-dependent accelerated substitution rates in prokary

50、otes biology-Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel biology-Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension biology-MiR-33 contributes to the regulation of cholesterol homeostasis biology-Neu

51、roscience and the correct level of explanation for understanding mind biology-Role of secondary sensory cortices in emotional memory storage and retrieval in rats biology-Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer biology-TGF-beta signaling specifies axons during brain devel

52、opment biology-The Amphimedon queenslandica genome and the evolution of animal complexity biology-The coevolution of human hands and feet biotech-Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5 biotech-Exploiting the determinants of stochastic gene expression in Sacch

53、aromyces cerevisiae for genome-wide prediction of expression noise biotech-Fragment-based drug discovery applied to hsp90. Discovery of two lead series with high ligand efficiency biotech-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis biotech-Metabolomic and transc

54、riptomic stress response of Escherichia coli biotech-Sex-specific parent-of-origin allelic expression in the mouse brain biotech-Small-molecule inducers of insulin expression in pancreatic alpha-cells biotech-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by s

55、olution NMR spectroscopy biotech-The genetic landscape of a cell biotech-Type IIA topoisomerase inhibition by a new class of antibacterial agents ca-A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution ca-Allogeneic hematopoietic cell transplan

56、tation for hematological malignancy ca-An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein ca-Cdc14- a highly conserved family of phosphatases with non-conserved functions ca-Early palliative care for patients with metastatic non鈥搒mall-cell lung cancer

57、 ca-Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes- a randomised, open-label, phase III study ca-Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma ca-Hematopoiesis in three dimensions- human and murine bone marrow architecture visualized by confocal microscopy ca-Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis ca-IFNalph