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5A216A217A218A219PDE4A220A221A222A223A224A225A226A227A229A218A230A214A231A232A198A233A234A235A236A225A205A238A239A233A234A235A236A225A240A241A239A233A234A235A236A242A243A244A245A246A235A236A2031A247A248A249A250A251A252A253A254A255A11A0A1A250A251A252A253A0A1A239A2A3A4A5A6A7A2A8A9A10A12A13A14A15A20A47A22CATALYSTA209A16A17A18A19A21A23A24A25A21A26A27A28A29A30A31A38A32A33A34A21A35A24A36A37A39A95A40A41A42A43A23A24A25A44A45A26A27A46A48A49A23A24A25A26A27A28A29A61A50A51A31A38A32A33A34A21A59A52A27A53A26A27A46A48A57A54A55A56A58A1382A49TABLE2THEMATCHINGOFCOMPOUNDSWITHPHARMACOPHORENOFITMAPPINGESTACTERROR177444286714071016452800437440130390223780431240130620321947914367401304803215574922615311304926677734512210660513772732624912105538880943754013032063297623267491094063151075344286714110913117323451221191191275634511811112111372734542212114151474034622211516115735436740131721216699345322142217716346622127221218643194811525581977343124013072253520643192811443621768345422108143532264243401315529236431953115818246441948114101425640192811610162664343401315101527706760201341544286444352251416112961519511281617306193422125171531648345122113191532617342212624113361734221262411346203422125311335627760201213115366084916132351137642192811540273864353623514402839619642542540164059534181444911416192922125532142620342212562254364443522514634444644435225146344456183322126762946614324912880294760734221338826485843233157901649497204531420904650605342213511032514723711274013057524984226141014029535019485380140275448420403156018031554711826376020038565281217282002301157567142348325035849994520400260155948894055202801860479133146403501861475371126904001762428261210043048635181334426047018644301712000500396548653261540580116648218633600700126742928132000750266847337112730910126951346361290120042704312640219001400137143026119001400147243019120001600127344426482140016001174423281230018001375435264021700190011764291712000300015774153022800310011784291712000460023794173912600480018804074133005200168141835132600810032824055313400900026834291013200011000558442814121001100053A60A623A63A64A65A66A225A67A78A68A94A69A70A63A71A72A73A74A75A76A73A77A85A79A80A228A81A82A832A189A84A86A87A88A89A90A184A91A92A93A1202A96A97A98A105A99A100A210A101A102A93FIT800,A103A104A106039NMOLL1A98A139A104A106020NMOLL1A97A107A103A104A105A99A108A109A98A110A88A89A111A112A113A114A115A116A117A118A107FIGURE2MAPPINGOFTHECOMPOUND2A119LEFTA121ANDCILOMILASTA119RIGHTA121ONTOTHEOPTIMALPHARMACOPHOREMODEL2A122A122A123A124A125A126A127A128A129A130A131A132A133A134A135A136A137A140A141A142A143A144A123A124A126A127A128A129A130A131A135A136A137A140A142A143A123A145A146A147A148A149A150A151A152A153A154A155PDE4A156A157A158A155A159A160A161A162A163A155A164A165A166A167A168A169A170A171A146A172A173A174A175A176A17717A178A169A179A180A181A155A182A183A185A155PDE4A156A157A158A186A187A188A159A160A161A162A163A147A190A146A191A173A192A167A193A194A195A196A166A147A190A146A197A198A199A200A201A202A2033A152A204A167A2033A172A173A174A175A177PDE4A205A206A158A186A159A160A161A162A163A191A173A200A201A207A208A183A185A155A211A212A159A174A2137A214,A147A215A216A217A218A219A220A221A155A22240A223A214A172A173A174,A224A223A226A176CILOMILASTA145A227A163,A194A195A229A178A230A231A147A190A232A233A192A234A235A236A237A238A155A199A195A240A230A241A182A183A185A155A172A173A174A200A242A167A186A162A163A155A243A244A166A176A245A196A166A197A198A246A247A248A249A250A251A252A2533A254A2033A192A2533A155A200A201A255A204A167A168A169A152A238A155A159A160A161A162A163A186A250A251A175A176A177A15517A178PDE4A205A206A158A243A244A166A35A0A167A194A195A196A166A197A198A246A186A165A69A246A170A35A145A1A44A167A70A147A148A149A130A37A146A168A162A163A155A71A0A197A198A97A2A192A164A165A166A199TABLE3THEMATCHINGOFOTHERCOMPOUNDSWITHPHARMACOPHORENOSTUCTUREACTA25NMOLL1A26ESTA25NMOLL1A26ERROR1CILOMILASTA3A4A5A6A6A5A7A6A3A63032112ROFLUMILASTA8A9A10A8A11A12A11A12A10A13A10A131615433A25CGH2466A26A14A15A14A15A16A17A16A16A18A191287510254CI1018A20A20A21A22A20A20A211100320345NITRAQUAZONENNNO2OO1900200016IBMXA23A23A23A24A23A27A2790006700137DENBUFYLINEA28A28A28A28A29A29A29800200025A94A30A31A32A331A34CILOMILASTA36A38A207A72A81A39A40A53A59PDE4A41A42A43A45A46A47A48A49A50A51A52A54A55A59A56A58A57A60A61A62A57A63A64A65A66FIT6537,A54A55A5732NMOLL1A45A61A55A5730NMOLL1A45ERROR11A67A68A73A60A48A49A50A51A52A189A74A59A75A76A66A1202A66A77A67A67A95A78A79A80A45CILOMILASTA59A75A82A60A48A49A50A51A52A59A189A74A83A207A84A85A45A73A86A59A87A88A89A90A66HBAA67A91A92A189A74A45A138A93A73A96A92A98A99A59A100A101A68A61A102A40CILOMILASTA59A56A58A83A207A103A104A45A233A105A59A106A74A107A56A58A108A109A110CILOMILASTA68A1383A86A59A106A74A1072A66ROFLUMILASTA67A133A72A111A112A59PDE4A41A42A43A113A47A114A115A116COPDA117A118A119A121A122A58A123A124A125A126A127A74A128ARDSA129A68A143A131A132A134ZHAOQIYANGA129A13516A136A78A225A137A139A140A141A142A75A82A144A145A133A146A147,A46A47COMFAA59A148A149A150A151A139PED4A41A42A43A152A153A154A155A68A73A225A137A156A59PDE4A41A42A43A59COMFAA75A76A157A1205A225A158A136A181A159A160A161A162A238A120A86A163A164A166A167A112A138A181A159A160A161A162A238A95A168A169PDE4A41A42A43A56A58A45A171A172A164A166A167A112A138A181A159A160A161A162A238A150PDE4A41A42A43A173A107A142A56A58A92A160A161A68A243A140A160A161A120A86A174A164A166A167A175A158A242A58A243A140A176A177A178A179PDE4A41A42A43A59A56A58A45A171A180A164A166A167A138A158A182A183A184A185A243A140A151A139A176A177A92A46A114A56A58A59A168A169A68A1205A47COMFAA137A156A59A75A76A45A243A140A160A161A162A238A66A186A67A121A181A159A160A161A162A238A7716A60A40A187A75A76A152A153A188A63A45A192A190A191A193A207A181A159A160A161A162A238A96A207A243A140A160A161A162A238A194A60A195A143A168A80A59A48A49A50A51A52A196A197A74A45A198A199A195A143A59A48A49A50A51A52A96A150A243A140A160A161A162A238A200A87A88A117A201A202A203A129A148A204A205A78A206A208A45A209A168A80A210A211A212A213A50A59A160A161A45A162A182A214A205A215A216A121A93A217A68A48A49A50A51A52A138A190A80A210A60A41A42A56A58A218A219A220A221A59A48A49A222A128A237A238A223A73A181A159A224A232A226A227A45A198A199A225A228A229A59A51A52A230A92A63A85A59A56A58A54A55A231A141A45A133A234A52A75A82A59PDE4A41A42A43A59A235A236A121A56A58A54A55A168A239A210A240A193A213A241A68A244A245A200A246A247A59PDE4A41A42A43A86A248A249A56A58A63A169A59A106A74A107A133A51A250A45A46A47MSIA251CATALYSTA252A253A254A45A255A110A76A240,A82A228A80A74A70A59PDE4A41A42A43A59A48A49A50A51A52A68A48A49A50A59A92A49A58A118A221A255A110A61A62A59A62A119A45A78A120A152A81A183A64A242A48A49A50A51A52A45A133A234A59A169A248A249A58A59PDE4A41A42A43A59A74A240A235A236A168A239A240A193A107A240A68A152A81A183A59A154A155A81A0A242A177A152A153A86A68A67A1A2A3A2A31A122A10A123,A4A124,A77A125A5A75A22A30A6A7A8A94A112A11A12A127A22A13A128A21A14A15A16A17A222006A2222101161A12972XUXJ,HOUTJ,QIAOXB,ETALCOMPUTERAIDEDDRUGDESIGNA18A19A20A23A24A25A26A27A28A29A18MBEIJINGA31CHEMICALINDUSTRYPRESS,2004A312953CROCKERCI,TOWNLEYRGTHERAPEUTICPOTENTIALOFPHOSPHODIESTERASE4INHIBITORSINALLERGICDISEASESJDRUGSTODAY,1999,35751925354TEIXEIRAMM,GRISTWOODRWPHOSPH
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