全面介绍地中海贫血

UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALUATIONORGANIZATIONS,POORORGANIZATION,THEPROBLEMSAREMANY,TOCRITICIZE,TOACCOUNTABILITYMAINISRESPONSIBLEFORCOMRADETOCONSCIOUSLYBEARUPFIRSTRESPONSIBILITYPEOPLEDUTIES,NOTONLYTOTUBEGOODCADRES,ANDWITHGOODTEAM,ALSOTOTUBEGOODMEMBERS,ANDWITHGOODTEAM,BOTHFIRSTEXAMPLES,LEADPARTICIPATEINLEARNINGEDUCATION,ANDBYQIANCOMMAND,INPUTENOUGHOFTIMEANDENERGY,STRENGTHENEDGUIDEANDCHECKSROLE,ONWORKPROGRAMMEPERSONALLYVALIDATION,ONIMPORTANTTASKPERSONALLYDEPLOYMENT,ONEXISTSPROBLEMTIMELYSOLUTION,THROUGHOUTPUTRESPONSIBILITYCARRYINSHOULDERSHANG,IMPROPER“SHUAISHOUZHANGGUI“THECOUNTYPARTYCOMMITTEEANDMUNICIPALPARTYCOMMITTEEMUNICIPALWORKERS,VARIOUSENTERPRISESANDINSTITUTIONS,COMMISSION,PARTYCOMMITTEESANDDEPARTMENTSINCHARGEOFINDUSTRYPRACTICE,DEVELOPSPECIFICIMPLEMENTATIONPLAN,ORGANIZINGSPECIALFORCESRESPONSIBLEFOREDUCATIONALWORKTOSTRENGTHENTHISUNITTOTHESYSTEMSTUDYANDEDUCATIONINTHEREGIONSPECIFICGUIDANCEORGANIZATIONDEPARTMENTS,ASTHELEADDEPARTMENT,TOSTRENGTHENTHEPLANNING,ORGANIZATION,COORDINATIONANDGUIDANCE,GOODDESIGN,DECOMPOSITION,EACHKEYACTIONTOIMPLEMENTCARRYOUTSTUDYANDEDUCATION,TORELYONSTRICTDOCREALGUIDE,PRESSURECONVEYINGLAYERUPONLAYER,STEPBYSTEP,COMPACTIONOFRESPONSIBILITYINSTEERINGTHESTEERINGMUSTPREVENTFORMALISM,CATCHTHEWAYTHETHINKINGOFPREVENTIONACTIVITIES,STUDYANDEDUCATION,PREVENTINGROUTINEASIDE,PREVENTSIMPLE,DOINGASMUCHASMEETINGNOTESTOJUDGETHEEDUCATIONALRESULTSTOTAKEREPORTS,CUSTOMIZEDRESEARCH,ATTENDINGTHEMEETING,RANDOMSPOTCHECKS,BRIEFINGSANDOTHERMEANS,TOFOCUSTHEPUSHGUIDETOGRASSROOTS,ONTHEPARTYBRANCH,INDEPTHUNDERSTANDINGOFEDUCATIONANDACTUALEFFECT,SUMUPFRESHEXPERIENCETOPROMOTEGRASSROOTS,TODETECTANDCORRECTTHESIGNSOFPROBLEMSPUBLICINFORMATIONDEPARTMENTSSHOULDPAYSPECIALATTENTIONTOPUBLICOPINION,INDEPTHINFORMATIONRELATINGTOPROVINCIAL,MUNICIPALANDCENTRALDECISIONSANDARRANGEMENTSTOPROMOTEEDUCATIONALEFFECTIVENESSANDPROGRESSOFTHETYPICALEXPERIENCE,ANDCREATEAGOODSOCIALATMOSPHERESECOND,PERSEVERINGINABOVERATESLEADINGBODIESATALLLEVELS,LEADERSHIP,LEADINGCADRESSHOULDTAKETHELEAD,ASAGOODEXAMPLE,ANDASKINGOTHERSTODOYOUFIRSTDOIT,ASKSOFOTHERSANDNOTTHEMSELVESDETERMINEDNOTTODO,FOREXAMPLEOFSUPERIORTOSUBORDINATE,TEAMLEADERFORTEAMMEMBERSFOREXAMPLE,LEVELTOLEVEL,LEVELWITHLEVELS,LAYERSOFDRIVENMODEL,LAYERUPONLAYER,FORMATIONOFTHESHOTS,THEOVERALLGENERALEFFECTOFLINKAGENEEDSTRESSEDOFIS,REGARDLESSOFWHATRANKS,ANDWHATPOSTOFMEMBERSLEADERS,ARETOTOGENERALMEMBERSIDENTITYPUTHIMSELFPENDULUMIN,SERIOUSLYIMPLEMENTATIONCENTRALANDPROVINCIAL,ANDMUNICIPALONLEARNINGEDUCATIONOFTHEREQUIREMENTS,STRICTLYIMPLEMENTATIONDOUBLEORGANISED,BASICSYSTEM,LEADLEARNINGDISCUSSION,LEADONEXPERIENCE,ANDTOLDPARTYLECTURE,ANDFORREPORT,LEADPARTICIPATEINORGANISEDWILL,ANDDEMOCRATICCOMMENTS,LEADSHOEVOCATIONALDUEDILIGENCE,ANDBASEDPOSTFORCONTRIBUTION,DO“FOURTOLDFOURHAS“OFQUALIFIEDCOMMUNIST,STRIVETOMAKESLEARNINGRESEARCHMOREINDEPTH,ANDCHECKPENDULUMPROBLEMMOREDEEP,TOREORGANIZETHEIMPLEMENTATIONOFMORERADICAL,AVANTGARDEMORERESPECTABLEIMAGE,THUSLEARNINGEDUCATIONEFFECTIVETHIRD,STRENGTHENTHEGUIDANCETHEEDUCATIONFORALLMEMBERS,LARGEPERSONNELBASE,WIDEFIELD,HIERARCHY,DIFFERENCE,ANDTODIFFERENTIATEBETWEENCOUNTIES,DEPARTMENTS,GRASSROOTSUNITS,ALLKINDSOFPARTYORGANIZATIONANDPARTYMEMBERBETWEENTHEACTUALCHARACTERISTICSOFHIERARCHICALCLASSIFICATIONPOSITIONSPUTFORWARDMEASURESTOPREVENT“FLOODIRRIGATION“TOHAVEOPERABLEEACHPARTYSHOULDDEVELOPSPECIFICPROGRAMMESANDSPECIFICMEASURES,EDUCATIONPRINCIPLESANDLEARNINGREQUIREMENTSINTOOPERATIONAL,ABLETOPUTINPLACEWAYSTOGRASPFROMTHESPECIFICWORK,HARD,CATCHINGFINEPRACTICE,WITHCONCRETERESULTSTOVERIFYTHEEDUCATIONALRESULTSSHOULDBETARGETEDDIFFERENTPARTYMEMBERSIDEOLOGICALTRENDSANDBEHAVIORS,DIFFERENTIALTREATMENTINEDUCATION,PRECISIONAPPLICATIONPOLICY,“KEYSTARTSLOCKS“,DOWNTOLEARNANDDOTHEMEASURESEACHPARTYMEMBER,ENABLINGTHEMTOACCESSTOEDUCATION,IMPROVE,MAKEPEOPLEFEELMEMBERSOFTHENEWCHANGESTOREFLECTTHEDIFFERENCENOUNIFORM,THOUSANDSOFPEOPLE,ANDGIVEEXPRESSIONDIFFERENCES,CHARACTERISTICSINDETERMININGTHELEARNINGWHENTHETOPICWASDISCUSSED,ACCORDINGTODIFFERENTCHARACTERISTICSANDEXISTINGPROBLEMSOFPARTYMEMBERS,BOTHCLOSELYLINKEDTOTHETHEME,ANDREALITY,LETPARTYMEMBERSLEARN,ONTHEUPDOQUALIFIEDCOMMUNISTOFSTANDARDALSOCANNOTUNIFORM,COUNTYABOVEMEMBERSLEADERSSTANDARDTOMOREHIGHMORESTRICT,TOINSISTEDLOYALTYCLEANPLAY,DOJIAOYULUTYPEOFGOODCADRESONCOUNTYFOLLOWINGTHEFIELDTHEINDUSTRYOFMEMBERSTO全面介绍地中海贫血地中海贫血又称海洋性贫血，是一组遗传性疾病。其发病机制是合成血红蛋白的珠蛋白链减少或缺失导致血红蛋白结构异常，这种含有异常血红蛋白的红细胞变形性降低，寿命缩短，可以提前被人体的肝脾等破坏，导致贫血甚至发育等异常，这种疾病也就是医学上讲的溶血性贫血。疾病分类地中海贫血按照受累的氨基酸链来分类，组成珠蛋白的肽链有4种，即、链，分别由其相应的基因编码，这些基因的缺失或点突变可造成各种肽链的合成障碍，致使血红蛋白的组分改变。通常将地中海贫血分为、和等4种类型，其中以和地中海贫血较为常见。也可按照一个或两个基因缺损来分为轻型或重型地中海贫血。病因及发病机制本病是由于珠蛋白基因的缺失或点突变所致。1地中海贫血人类珠蛋白基因簇位于11P155。地中海贫血（简称地贫）的发生主要是由于基因的点突变，少数为基因缺失。基因缺失和有些点突变可致链的生成完全受抑制，称为0地贫；有些点突变使链的生成部分受抑制，则称为地贫。UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALUATIONORGANIZATIONS,POORORGANIZATION,THEPROBLEMSAREMANY,TOCRITICIZE,TOACCOUNTABILITYMAINISRESPONSIBLEFORCOMRADETOCONSCIOUSLYBEARUPFIRSTRESPONSIBILITYPEOPLEDUTIES,NOTONLYTOTUBEGOODCADRES,ANDWITHGOODTEAM,ALSOTOTUBEGOODMEMBERS,ANDWITHGOODTEAM,BOTHFIRSTEXAMPLES,LEADPARTICIPATEINLEARNINGEDUCATION,ANDBYQIANCOMMAND,INPUTENOUGHOFTIMEANDENERGY,STRENGTHENEDGUIDEANDCHECKSROLE,ONWORKPROGRAMMEPERSONALLYVALIDATION,ONIMPORTANTTASKPERSONALLYDEPLOYMENT,ONEXISTSPROBLEMTIMELYSOLUTION,THROUGHOUTPUTRESPONSIBILITYCARRYINSHOULDERSHANG,IMPROPER“SHUAISHOUZHANGGUI“THECOUNTYPARTYCOMMITTEEANDMUNICIPALPARTYCOMMITTEEMUNICIPALWORKERS,VARIOUSENTERPRISESANDINSTITUTIONS,COMMISSION,PARTYCOMMITTEESANDDEPARTMENTSINCHARGEOFINDUSTRYPRACTICE,DEVELOPSPECIFICIMPLEMENTATIONPLAN,ORGANIZINGSPECIALFORCESRESPONSIBLEFOREDUCATIONALWORKTOSTRENGTHENTHISUNITTOTHESYSTEMSTUDYANDEDUCATIONINTHEREGIONSPECIFICGUIDANCEORGANIZATIONDEPARTMENTS,ASTHELEADDEPARTMENT,TOSTRENGTHENTHEPLANNING,ORGANIZATION,COORDINATIONANDGUIDANCE,GOODDESIGN,DECOMPOSITION,EACHKEYACTIONTOIMPLEMENTCARRYOUTSTUDYANDEDUCATION,TORELYONSTRICTDOCREALGUIDE,PRESSURECONVEYINGLAYERUPONLAYER,STEPBYSTEP,COMPACTIONOFRESPONSIBILITYINSTEERINGTHESTEERINGMUSTPREVENTFORMALISM,CATCHTHEWAYTHETHINKINGOFPREVENTIONACTIVITIES,STUDYANDEDUCATION,PREVENTINGROUTINEASIDE,PREVENTSIMPLE,DOINGASMUCHASMEETINGNOTESTOJUDGETHEEDUCATIONALRESULTSTOTAKEREPORTS,CUSTOMIZEDRESEARCH,ATTENDINGTHEMEETING,RANDOMSPOTCHECKS,BRIEFINGSANDOTHERMEANS,TOFOCUSTHEPUSHGUIDETOGRASSROOTS,ONTHEPARTYBRANCH,INDEPTHUNDERSTANDINGOFEDUCATIONANDACTUALEFFECT,SUMUPFRESHEXPERIENCETOPROMOTEGRASSROOTS,TODETECTANDCORRECTTHESIGNSOFPROBLEMSPUBLICINFORMATIONDEPARTMENTSSHOULDPAYSPECIALATTENTIONTOPUBLICOPINION,INDEPTHINFORMATIONRELATINGTOPROVINCIAL,MUNICIPALANDCENTRALDECISIONSANDARRANGEMENTSTOPROMOTEEDUCATIONALEFFECTIVENESSANDPROGRESSOFTHETYPICALEXPERIENCE,ANDCREATEAGOODSOCIALATMOSPHERESECOND,PERSEVERINGINABOVERATESLEADINGBODIESATALLLEVELS,LEADERSHIP,LEADINGCADRESSHOULDTAKETHELEAD,ASAGOODEXAMPLE,ANDASKINGOTHERSTODOYOUFIRSTDOIT,ASKSOFOTHERSANDNOTTHEMSELVESDETERMINEDNOTTODO,FOREXAMPLEOFSUPERIORTOSUBORDINATE,TEAMLEADERFORTEAMMEMBERSFOREXAMPLE,LEVELTOLEVEL,LEVELWITHLEVELS,LAYERSOFDRIVENMODEL,LAYERUPONLAYER,FORMATIONOFTHESHOTS,THEOVERALLGENERALEFFECTOFLINKAGENEEDSTRESSEDOFIS,REGARDLESSOFWHATRANKS,ANDWHATPOSTOFMEMBERSLEADERS,ARETOTOGENERALMEMBERSIDENTITYPUTHIMSELFPENDULUMIN,SERIOUSLYIMPLEMENTATIONCENTRALANDPROVINCIAL,ANDMUNICIPALONLEARNINGEDUCATIONOFTHEREQUIREMENTS,STRICTLYIMPLEMENTATIONDOUBLEORGANISED,BASICSYSTEM,LEADLEARNINGDISCUSSION,LEADONEXPERIENCE,ANDTOLDPARTYLECTURE,ANDFORREPORT,LEADPARTICIPATEINORGANISEDWILL,ANDDEMOCRATICCOMMENTS,LEADSHOEVOCATIONALDUEDILIGENCE,ANDBASEDPOSTFORCONTRIBUTION,DO“FOURTOLDFOURHAS“OFQUALIFIEDCOMMUNIST,STRIVETOMAKESLEARNINGRESEARCHMOREINDEPTH,ANDCHECKPENDULUMPROBLEMMOREDEEP,TOREORGANIZETHEIMPLEMENTATIONOFMORERADICAL,AVANTGARDEMORERESPECTABLEIMAGE,THUSLEARNINGEDUCATIONEFFECTIVETHIRD,STRENGTHENTHEGUIDANCETHEEDUCATIONFORALLMEMBERS,LARGEPERSONNELBASE,WIDEFIELD,HIERARCHY,DIFFERENCE,ANDTODIFFERENTIATEBETWEENCOUNTIES,DEPARTMENTS,GRASSROOTSUNITS,ALLKINDSOFPARTYORGANIZATIONANDPARTYMEMBERBETWEENTHEACTUALCHARACTERISTICSOFHIERARCHICALCLASSIFICATIONPOSITIONSPUTFORWARDMEASURESTOPREVENT“FLOODIRRIGATION“TOHAVEOPERABLEEACHPARTYSHOULDDEVELOPSPECIFICPROGRAMMESANDSPECIFICMEASURES,EDUCATIONPRINCIPLESANDLEARNINGREQUIREMENTSINTOOPERATIONAL,ABLETOPUTINPLACEWAYSTOGRASPFROMTHESPECIFICWORK,HARD,CATCHINGFINEPRACTICE,WITHCONCRETERESULTSTOVERIFYTHEEDUCATIONALRESULTSSHOULDBETARGETEDDIFFERENTPARTYMEMBERSIDEOLOGICALTRENDSANDBEHAVIORS,DIFFERENTIALTREATMENTINEDUCATION,PRECISIONAPPLICATIONPOLICY,“KEYSTARTSLOCKS“,DOWNTOLEARNANDDOTHEMEASURESEACHPARTYMEMBER,ENABLINGTHEMTOACCESSTOEDUCATION,IMPROVE,MAKEPEOPLEFEELMEMBERSOFTHENEWCHANGESTOREFLECTTHEDIFFERENCENOUNIFORM,THOUSANDSOFPEOPLE,ANDGIVEEXPRESSIONDIFFERENCES,CHARACTERISTICSINDETERMININGTHELEARNINGWHENTHETOPICWASDISCUSSED,ACCORDINGTODIFFERENTCHARACTERISTICSANDEXISTINGPROBLEMSOFPARTYMEMBERS,BOTHCLOSELYLINKEDTOTHETHEME,ANDREALITY,LETPARTYMEMBERSLEARN,ONTHEUPDOQUALIFIEDCOMMUNISTOFSTANDARDALSOCANNOTUNIFORM,COUNTYABOVEMEMBERSLEADERSSTANDARDTOMOREHIGHMORESTRICT,TOINSISTEDLOYALTYCLEANPLAY,DOJIAOYULUTYPEOFGOODCADRESONCOUNTYFOLLOWINGTHEFIELDTHEINDUSTRYOFMEMBERSTO地贫基因突变较多，迄今已发现的突变点达100多种，国内已发现28种。其中常见的突变有6种4142（TCTT，约占45；IVS654CT，约占24；17AT；约占14；TATA盒28AT，约占9；7172（A,约占2；26GA，即HBE26，约占2。重型地贫是0或地贫的纯合子或0与地贫双重杂合子，因链生成完全或几乎完全受到抑制，以致含有链的HBA合成减少或消失，而多余的链则与链结合而成为HBFA22），使HBF明显增加。由于HBF的氧亲合力高，致患者组织缺氧。过剩的链沉积于幼红细胞和红细胞中，形成链包涵体附着于红细胞膜上而使其变僵硬，在骨髓内大多被破坏而导致“无效造血”。部分含有包涵体的红细胞虽能成熟并被释放至外周血，但当它们通过微循环时就容易被破坏；这种包涵体还影响红细胞膜的通透性，从而导致红细胞的寿命缩短。由于以上原因，患儿在临床上呈慢性溶血性贫血。贫血和缺氧刺激红细胞生成素的分泌量增加，促使骨髓增加造血，因而引起骨骼的改变。贫血使肠道对铁的吸收增加，加上在治疗过程中的反复输血，使铁在组织中大量贮存，导致含铁血黄素沉着症。轻型地贫是0或地贫的杂合子状态，链的合UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALUATIONORGANIZATIONS,POORORGANIZATION,THEPROBLEMSAREMANY,TOCRITICIZE,TOACCOUNTABILITYMAINISRESPONSIBLEFORCOMRADETOCONSCIOUSLYBEARUPFIRSTRESPONSIBILITYPEOPLEDUTIES,NOTONLYTOTUBEGOODCADRES,ANDWITHGOODTEAM,ALSOTOTUBEGOODMEMBERS,ANDWITHGOODTEAM,BOTHFIRSTEXAMPLES,LEADPARTICIPATEINLEARNINGEDUCATION,ANDBYQIANCOMMAND,INPUTENOUGHOFTIMEANDENERGY,STRENGTHENEDGUIDEANDCHECKSROLE,ONWORKPROGRAMMEPERSONALLYVALIDATION,ONIMPORTANTTASKPERSONALLYDEPLOYMENT,ONEXISTSPROBLEMTIMELYSOLUTION,THROUGHOUTPUTRESPONSIBILITYCARRYINSHOULDERSHANG,IMPROPER“SHUAISHOUZHANGGUI“THECOUNTYPARTYCOMMITTEEANDMUNICIPALPARTYCOMMITTEEMUNICIPALWORKERS,VARIOUSENTERPRISESANDINSTITUTIONS,COMMISSION,PARTYCOMMITTEESANDDEPARTMENTSINCHARGEOFINDUSTRYPRACTICE,DEVELOPSPECIFICIMPLEMENTATIONPLAN,ORGANIZINGSPECIALFORCESRESPONSIBLEFOREDUCATIONALWORKTOSTRENGTHENTHISUNITTOTHESYSTEMSTUDYANDEDUCATIONINTHEREGIONSPECIFICGUIDANCEORGANIZATIONDEPARTMENTS,ASTHELEADDEPARTMENT,TOSTRENGTHENTHEPLANNING,ORGANIZATION,COORDINATIONANDGUIDANCE,GOODDESIGN,DECOMPOSITION,EACHKEYACTIONTOIMPLEMENTCARRYOUTSTUDYANDEDUCATION,TORELYONSTRICTDOCREALGUIDE,PRESSURECONVEYINGLAYERUPONLAYER,STEPBYSTEP,COMPACTIONOFRESPONSIBILITYINSTEERINGTHESTEERINGMUSTPREVENTFORMALISM,CATCHTHEWAYTHETHINKINGOFPREVENTIONACTIVITIES,STUDYANDEDUCATION,PREVENTINGROUTINEASIDE,PREVENTSIMPLE,DOINGASMUCHASMEETINGNOTESTOJUDGETHEEDUCATIONALRESULTSTOTAKEREPORTS,CUSTOMIZEDRESEARCH,ATTENDINGTHEMEETING,RANDOMSPOTCHECKS,BRIEFINGSANDOTHERMEANS,TOFOCUSTHEPUSHGUIDETOGRASSROOTS,ONTHEPARTYBRANCH,INDEPTHUNDERSTANDINGOFEDUCATIONANDACTUALEFFECT,SUMUPFRESHEXPERIENCETOPROMOTEGRASSROOTS,TODETECTANDCORRECTTHESIGNSOFPROBLEMSPUBLICINFORMATIONDEPARTMENTSSHOULDPAYSPECIALATTENTIONTOPUBLICOPINION,INDEPTHINFORMATIONRELATINGTOPROVINCIAL,MUNICIPALANDCENTRALDECISIONSANDARRANGEMENTSTOPROMOTEEDUCATIONALEFFECTIVENESSANDPROGRESSOFTHETYPICALEXPERIENCE,ANDCREATEAGOODSOCIALATMOSPHERESECOND,PERSEVERINGINABOVERATESLEADINGBODIESATALLLEVELS,LEADERSHIP,LEADINGCADRESSHOULDTAKETHELEAD,ASAGOODEXAMPLE,ANDASKINGOTHERSTODOYOUFIRSTDOIT,ASKSOFOTHERSANDNOTTHEMSELVESDETERMINEDNOTTODO,FOREXAMPLEOFSUPERIORTOSUBORDINATE,TEAMLEADERFORTEAMMEMBERSFOREXAMPLE,LEVELTOLEVEL,LEVELWITHLEVELS,LAYERSOFDRIVENMODEL,LAYERUPONLAYER,FORMATIONOFTHESHOTS,THEOVERALLGENERALEFFECTOFLINKAGENEEDSTRESSEDOFIS,REGARDLESSOFWHATRANKS,ANDWHATPOSTOFMEMBERSLEADERS,ARETOTOGENERALMEMBERSIDENTITYPUTHIMSELFPENDULUMIN,SERIOUSLYIMPLEMENTATIONCENTRALANDPROVINCIAL,ANDMUNICIPALONLEARNINGEDUCATIONOFTHEREQUIREMENTS,STRICTLYIMPLEMENTATIONDOUBLEORGANISED,BASICSYSTEM,LEADLEARNINGDISCUSSION,LEADONEXPERIENCE,ANDTOLDPARTYLECTURE,ANDFORREPORT,LEADPARTICIPATEINORGANISEDWILL,ANDDEMOCRATICCOMMENTS,LEADSHOEVOCATIONALDUEDILIGENCE,ANDBASEDPOSTFORCONTRIBUTION,DO“FOURTOLDFOURHAS“OFQUALIFIEDCOMMUNIST,STRIVETOMAKESLEARNINGRESEARCHMOREINDEPTH,ANDCHECKPENDULUMPROBLEMMOREDEEP,TOREORGANIZETHEIMPLEMENTATIONOFMORERADICAL,AVANTGARDEMORERESPECTABLEIMAGE,THUSLEARNINGEDUCATIONEFFECTIVETHIRD,STRENGTHENTHEGUIDANCETHEEDUCATIONFORALLMEMBERS,LARGEPERSONNELBASE,WIDEFIELD,HIERARCHY,DIFFERENCE,ANDTODIFFERENTIATEBETWEENCOUNTIES,DEPARTMENTS,GRASSROOTSUNITS,ALLKINDSOFPARTYORGANIZATIONANDPARTYMEMBERBETWEENTHEACTUALCHARACTERISTICSOFHIERARCHICALCLASSIFICATIONPOSITIONSPUTFORWARDMEASURESTOPREVENT“FLOODIRRIGATION“TOHAVEOPERABLEEACHPARTYSHOULDDEVELOPSPECIFICPROGRAMMESANDSPECIFICMEASURES,EDUCATIONPRINCIPLESANDLEARNINGREQUIREMENTSINTOOPERATIONAL,ABLETOPUTINPLACEWAYSTOGRASPFROMTHESPECIFICWORK,HARD,CATCHINGFINEPRACTICE,WITHCONCRETERESULTSTOVERIFYTHEEDUCATIONALRESULTSSHOULDBETARGETEDDIFFERENTPARTYMEMBERSIDEOLOGICALTRENDSANDBEHAVIORS,DIFFERENTIALTREATMENTINEDUCATION,PRECISIONAPPLICATIONPOLICY,“KEYSTARTSLOCKS“,DOWNTOLEARNANDDOTHEMEASURESEACHPARTYMEMBER,ENABLINGTHEMTOACCESSTOEDUCATION,IMPROVE,MAKEPEOPLEFEELMEMBERSOFTHENEWCHANGESTOREFLECTTHEDIFFERENCENOUNIFORM,THOUSANDSOFPEOPLE,ANDGIVEEXPRESSIONDIFFERENCES,CHARACTERISTICSINDETERMININGTHELEARNINGWHENTHETOPICWASDISCUSSED,ACCORDINGTODIFFERENTCHARACTERISTICSANDEXISTINGPROBLEMSOFPARTYMEMBERS,BOTHCLOSELYLINKEDTOTHETHEME,ANDREALITY,LETPARTYMEMBERSLEARN,ONTHEUPDOQUALIFIEDCOMMUNISTOFSTANDARDALSOCANNOTUNIFORM,COUNTYABOVEMEMBERSLEADERSSTANDARDTOMOREHIGHMORESTRICT,TOINSISTEDLOYALTYCLEANPLAY,DOJIAOYULUTYPEOFGOODCADRESONCOUNTYFOLLOWINGTHEFIELDTHEINDUSTRYOFMEMBERSTO成仅轻度减少，故其病理生理改变极轻微。中间型地贫是一些地贫的双重杂合子和某些地贫的变异型的纯合子，或两种不同变异型珠蛋白生成障碍性贫血的双重杂合子状态，其病理生理改变介于重型和轻型之间。2地中海贫血人类珠蛋白基因簇位于16PTERP133。每条染色体各有2个珠蛋基因，一对染色体共有4个珠蛋白基因。大多数地中海贫血（简称地贫）是由于珠蛋白基因的缺失所致，少数由基因点突变造成。若仅是一条染色体上的一个基因缺失或缺陷，则链的合成部分受抑制，称为地贫；若每一条染色体上的2个基因均缺失或缺陷，称为0地贫。重型地贫是0地贫的纯合子状态，其4个珠蛋白基因均缺失或缺陷，以致完全无链生成，因而含有链的HHA、HBA2和HBF的合成均减少。患者在胎儿期即发生大量链合成4（HBBARTS）。HBBARTS对氧的亲合力极高，造成组织缺氧而引起胎儿水肿综合征。中间型和地贫是0和地贫的杂合子状态，是由3个珠蛋白基因缺失或缺陷所造成，患者仅能合成少量链，其多余的链即合成HBH（4）。HBH对氧亲合力较高，又是一种不稳定血红蛋白，容易在红细胞内变性沉淀而形成包涵体，造成红细胞膜僵硬而使红细胞寿命缩短。轻型地贫是地贫纯合子或0地贫杂合子状态，UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALU