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西咪替丁抗肿瘤机制研究进展马丽娟，王卓，胡晋红（第二军医大学长海医院药学部上海200433）A1A0A1A0A1A0A3A3A3A2A4A5A6A7A8A9A10A11A12A13A14A15A16A17A18A19A20A21A22A23A24A25A26A27A6A7A8A9A28A29A30A31A32A33A34A17A35A5A36A37A38A39A40A28A41A42A43A17A44A10A40A45A46A11A12A29A30A47A48A49A21A22A50A51A52A53A28A54A55A56A57A14A58A59A60A61A62A57A14A11A12A60A63A33A34A17A57A14A11A12A64A65VEGFA66A67A17A57A14A11A12A28A60A63A17A68A36A37A58A69VEGFA66A67A56A57A14A70A71A72A73A74A28A75A76A62A77A78A10A11A12A17A50A51A57A14A79A80A49A81A43A11A12A12A82A60A63A46A58A83A84A85A28A33A34A56A6A7A8A9A35A86A87A88A89A90A91A92A93A60A94A95A96A97A17A98A99A100A101A102A103A17A104A105A106A107A80A87A88A28A108A109A110A102A103A111A10A11A12A27A112A113A114A112A113A115A6A7A8A9A29A30A31A32A57A14A6A7A8A9A116A117A118A119A7A120,A121A122A123,A15A124A125A72A73A43A28H2A126A82A127A128A129,A130A131A57A14A64A132A133A134A135A122A136A74A137A138A139A77A28A122A140A91A136,A18A62A76A78A10A140A28A33A34A27A141A142A143A144A145A34A146A47A48A122A147A148A149A150A79A151A152A110A143A153A97A154A155A58A49A156A157A158A111,A159A160A161A162A163A164A165A28A166A128A100A23A46A141A142A167A34A28A108A168,A93A169A50A51A170A168A166A171A172A101A173H2A126A82A174A10A129A28A175A33A34A27A176A177A178A179A180A46A141A142A164A165A181A75A94A6A7A8A9A50A51A182A47A168A183A81A43A11A12A184A185A46A186A124A187A188A60A189A190A28A33A341A191A56A6A7A8A9A35A106A107A168A183A10A11A12A161A192A28A161A193A194A195A163A105A196A17A86A197A198A10A12A161A192A199A200A201A108A202A46A161A203A204A205A206A22A207A108A2022A49A27A169A208A101A10A11A12A13A14A33A52A209A26A27一、免疫调节作用A210A211A212A213A214A215A216A217A218A219A220A221A222A223A224A225A226A227A228A229A230A231A232A233A234A235A236A237A238A239A240A234A241A242A215A216A223A243A244A245A246A247A248A249A250A251A252A253A254A255A139A0A1A2A3A4A5A248A6A7A8A9A254A255A10A11A4A12A13A25A163A14A15A16A224A62A17A249A18A19A254A255A20A21A22A23A244A4A24A26A27A28A29A30A224A203A31A32A254A255A33A34A246A35A10A11A12A13A224A7A62A17A34A246A60A31A32A36A372A4A38A39A249A250A251A40A41A31A32A42A43A4H2A120A44A7A45A46A12A13A4A25A47A48A49A59A251A50A51A52A204A53A254A255A5A248A54A55A52A242A56A33A34A246A35TA244TSA245A31A32A57A4A58A242A52A171A61A63A64A65A66A67A49A59A31A32A85A68A69A70A224A253A71A40A41A31A32A20A21A72A73A52A61A74A75A76A31A32NKCA77A35A70A78A79A40A41A31A32A252A80A81A78A69A25A82A48A245A44A47A48A83A84A86A78A52A247A87A88A89A51A62A17A90A118A91A165A92A48A93A94A200A2A95A4A96A35A31A32A97A98A99A100A101A62A17A52A6A7A84A86TA31A32A4A5A248A52A102A59A254A255A34A246A25A7A103A104A105A106A244CMDA245A12A13A107TA31A32A108A4H2A120A44A224A34A246A31A32A4A77A35A52A147A109A62A17A4A34A246A12A13A25CMDA248A252A124A110A44A71A59A52A10A111T1A31A32A112THA31A32A113A114A35TA31A32A4A115A116A52A117A33A110A119A121A23A122A31A32A254A255A12A13A52A123A124A125A126A127A128A129A31A32A139A0A130A109A110A131A4A125A194A224A72A132A110A131A251A133A134A254A255A135A71A254A4A49A59A79A72A136A254A255A135A71A254A137A200A47A62A138A108A4A88A140A12A141A142A143A144A145A146A148A149A1501949A151A152A153A154A155A153A156A157A158A159A160A161A162A164A166A167A168A169A170A172EMAILHUJHSMMUEDUCNA143A144A173A174A145A175A176A1771982A159A178A159A152A153A156A172EMAILMALIJUAN190719163COMA179A180200433A141A142A181A182A183A161A160A161A184168A185A160A161A162A164A166A167A168A13A52A6A7A186A135A187A2A3A186A135A254A255A20A21A187A254A255A31A32A77A35A25A188DAMSA57A26A189A47A30A62A190A191A192A193A51A195A196A9A52A197A67A252A48A198A189A199A201A202A205A206A103A104A105A1061A207A208A52A45A163A103A104A105A106A248A209A210A252A124A93A211A62A138A4A40A41A31A32A212A213A214A52A103A104A105A106A62A21567A216A52A203A217A62A218A21524A216P001A52A165A92A219A45A163A40A41A31A32A212A213A214A19A198A189A201A208A39A220A221A222A210A223A225A226A227A224A228A229A52ADAMSA57A4A230A231A42A209A52A103A104A105A106A247A232A118A93A211A233A2A4A254A255A5A248A25A234A107A103A104A105A106A4A254A255A10A11A235A248A52A247A236A69A70A237A238A140A4A239A240A35A52A47A110A140A241A121A93A211A254A255A243A246A57A247A43A117A33A30A248A4A249A1163A52A14A250A59A5A13A251A255A135A67A70A252A48A57A77A0A1A35A93A211A141A70A71A0A72A2A60A89A83A141A162A3A74A4A5A76A6A38A7A78A8A38A62A211A9A10A80A181A11A12A13A14A15A164A25二、抑制血管生成而抑制肿瘤生长作用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,VEGFA36A100A101A102A18A19A103A104A105A106A39A107A108A109A110A111A50A51A18A19A26A112A113A44A52A53A107A49810A50A58A60VEGFA26A114A115A57A116A117A58A60A118A119A115A18A19A26A34A48A44A52A53A26A37A3411A47A151A17A20A21A110A116A159A122A123A124A58A60A18A19A54A49A26A32A33A34A35A50A125A73A126A127A42A18A19A128A129A47TOMITAA13012A131A83A132A252A101A133A134A135A132A53A136A19A137A138A50A139A140A159A122A123A1244A142A50A252A143A159A122A123A124A117A144A58A60A18A19A105A106VEGFA145A146A50A58A60A18A19A26A34A48A50A66A147A148A32A149VEGFA145A146A50A117A144A150A152A18A19A105A106A26A18A19A32A33A244MVDA245A50A153A154A105A106A155A156A47A157A158A13013A20A21A210A159A122A123A124A160A161A101A134A135A132A163A199A53A136A19A34A48A26A128A129A50A164A137A165A43A45A105A166A167A163A199A168A170A159A122A123A124A50A19A171A172A173A160A174A105A50A737A142A175A50A176A104A26A177A246A178A59A116A117A507A142A165A118A119A252A179A50A159A122A123A124A58A19A180A11177A50A182A183A184A185A110A116A159A122A123A124A160A18A19A26A37A34A186A37A27A31A118A125A58A60A128A129A50A187A160A188A165A26A189A190A191A129A192A193A210A194A195A196A197A47三、抑制E选择素的表达而起到抗肿瘤的作用A198A200A50A107A20A21A201A102A50A159A122A123A124A56A202A203A65A58A60A204A163A93A94A182A205A207A208A209A212A26A110A111A213A121A89A134A93A94A26A52A53A50A215A107A58A60A101A134A130A216A115A18A19A19A171A34A48A44A32A217A218A219A26A128A129A220A221A222A223A50A224A66A225A226A118A227A65A67A228A40A30A203A65A159A122A123A124A58A60A32A33A204A163A93A94A110A111A205A207A208A209A212A50A229A230A58A60A210A18A19A93A94A51A32A33A204A163A93A94A26A231A232A230A37A233A128A129A26A220A221A234A223A47A159A122A123A124A42A18A19A128A129A26A235A236A237A238A84A239A240A59A51A241A242A92A57A153A243A107A49A50A247A248A249A241A242A92A57A26A63A212A250A95A47A251A253A254A104A20A21A255A157A172A159A122A123A124A26A241A242A4A114A128A129A30A203A65A153A243A18A19A93A94A110A31A26A231A232A89A75A110A111A50A142A251A0A37A91A26A205A207A208A209A212A50A98A230A98A4A1A2A93A94A153A3A224A5A6A7A115A144A1A2A93A94A26A114A115A192A108A50A99A34A160A18A19A93A94A26A6A7A128A129A50A229A230A111A73A42A18A19A26A198A26A47A145A8A254A104A203A65A93A94A44A9A10A137A138A118A119A220A221A222A223A226A118A159A122A123A124A58A60A18A19A93A94A52A53A26A128A129A56A57A30A203A65A199A79A204A163A93A94ESELECTINA244CD62EA245A110A111A50A229A230A121A89A18A19A93A94A51A204A163A93A94A231A232A230A118A91A26A47A151A151A146A29A41A145A8A254A104A36A189A190A20A2115A39A14A98A29A147A119A226A210A187A214A56A57A172A36A100A134A44A252A101A134A103A104A39A195A45A73A103A104A32A149A39A26ESELECTINA36A191A129A159A122A123A124A165A37A34A210A116A117A26A199A147A50A240A59ESELECTINA30A18A19A32A217A52A53A26A23A40A63A75A50A159A122A123A124A58A60A18A19A52A53A26A128A129A250A56A57A203A65A205A207A148A11A12A11A13A15A16A17A125A128A129A220A221A18A223A47四、通过影响癌细胞的增殖及凋亡来抗肿瘤A155A19A20A21A22A23A24A19A21A25A19A26A27A28A29A30A158A32A33A34A35A36A37A38A39A40A70A41A55A42A43A141A70A77A44A46A47A160A19A160A48A69A162A49A50A51A52A53A54A99A56A57A58A56A57A100A59A60A61A106A62A49A63A64A46A47A62A57A101A163A35A46A47A56A57A85A65A66A49A67A68A71A68A72A73A74A75A76A78A213A79A80A81A164A36A37A38A39A40A82A46A47A83A84A86A87A67A68A34A88A90A92A224A36A37A38A39A80A81A46A47A165A93A94A95A35A168A96A97A168A102A84A46A47A50A103A35A104A84A71A168A162A97A171A84A46A47A105A107A224A46A47A108A109A61A168A96A97A168A102A84A110A82A46A47A83A84A54A74A111A108A35A112A113A46A47A78A173A86A174A35A114A110A55A42A46A47A68A72A224A175A115A36A37A38A39A40A116A117A73A177A118A56A57A35A112A113A46A47A83A84A54A74A119A55A42A46A47A50A51A58A178A120A26A63A162A71A178A19A121A100A214A180A46A47A56A57A49A63A122A123A124A35A178A19A121A100A181A125A178A120A26A63A162A126A211A127A232A183A49A123A124A35A178A19A121A127A232A226A178A120A26A63A162A127A232A128A129A78A162A102A130A49A60A185A131A35A76A78A122A132A178A120A26A69A162A127A232A55A42A46A47A56A57A49A80A81A224A133A134A35A211A61A36A37A38A39A53A56A57A135A42A49A158A32A186A107A224A187A136A188A137A27A28A138A30A114A36A37A38A39A122A46A47A56A57A126A211A123A124A178A120A26A63A162A71A178A19A121A49A214A180A139A194A190A140A210A99A80A81A135A42A224A43A143A67A149A35A36A37A38A39A40A150A214A178A120A26A69A162A127A232A33A152A35A60A153A154A214A178A19A121A127A232A33A152A224A33A34A36A37A38A39A40A116A117A73A150A214A178A120A26A69A162A127A232A33A152A35A154A214A178A19A121A127A232A33A152A156A177A118A159A44A46A47A56A57A224A161A43A143A166A167A169A170A81A36A37A38A39A176A179A159A44A182A184A210A189A191A71A192A193A195A196A164MA224FUKUDAA137A158A32A67A149A36A37A38A39A40A116A117A73A55A42A197A198A168A46A47A49A68A72A119A122A132A199A131A49A200A201A202A65A66A58A203A231A35A36A37A38A39A85A167A169A154A204A205A216A206A207A208A141A209A212A208A141A215A92A216A206A207A208A137A217A78A218A219A220A170A81A35A221A72A84A170A81A52A59A222A50A103A223A225A65A66A227A202A44A49A67A208A228A229A27A28A230A30A35A78A218A219A220A49A170A81A134A233A58A234A78A235A236A237A166A35A36A37A38A39A49A132A65A66A80A81A78A238A35A239A81A240A241A85A242A150A243A244A238A61A43A77A44A141A245A46A47A44A137A101A246A35A52A221A100A80A166A247A248A176A179A249A250A231A63A35A251A252A122A253A254A65A66A255A176A9A179A215A76A78A213A79A49A48A118A8A0A58A60A153A234A59A170A161A133A133A84A122A99A217A52A73A1A156A2A3A81A27A4A12A30A219A124A63A85A190A140A160A171A171A167A169A132A65A66A80A81A49A73A74A75A219A170A221A5A6A7A123A18A71A179A74A164A225A10A11A2261MATSUMOTOS,IMAEDAY,UMEMOTOS,ETALCIMETIDINEINCREASESSURVIVALOFCOLORECTALCANCERPATIENTSWITHHIGHLEVELSOFSIALYLLEWISXANDSIALYLLEWISAEPITOPEEXPRESSIONONTUMOURCELLSMBRJCANCER2002,86A2272A228A1721591602A229A13A14A36A37A38A39A167A169A170A81A49A9A54A15A189A81A232A16A17A19A352006A359A24418A245A172320132023SZINCSAKNA35HEGYESIHA35HUNYADIJA35ETA1A224CIMETIDINEANDATAMOXIFENDERIVATEREDUCETUMOURFORMATIONINSCIDMICEXENOTRANSPLANTEDWITHAHUMANMELANOMACELLLINEJA35MELANOMARESA352002A35123A1722314CHANGSWA35HUANGZLA224ORALCIMETIDINEADJUVANTTHERAPYFORRECALCITRANTA35DIFFUSECONJUNCTIVALPAPILLOMATOSISJA224CORNEAA352006A35256A172687A2245FOLKMANJA224ROLEOFANGIOGENESISINTUMORGROWTHANDMETASTASISJA224SEMINONCOLA352002A35296SUPPL16A17215A23518A2246NATORITA35SATAMA35WASHIDAMA35ETA1A224GCSFSTIMULATESANGIOGENESISANDPROMOTESTUMORGROWTHA172POTENTIALCONTRIBUTIONOFBONEMAROWA235DERIVEDENDOTHELIALPROGENITORCELLSJA224BIOCHEMBIOPHYSRESCOMMUNA352002A352974587OREILLYMS,BOEHMT,SHINGY,FUKAIN,VASIOSG,LANEWS,ETALENDOSTATINANENDOGENOUSINHIBITOROFANGIOGENESISANDTUMORGROWTHCELL199788277858FOLKMANJA35SHINGYA224CONTROLOFANGIOGENESISBYHEPARINANDOTHERSULFATEDPOLYSACCHARIDESJA224ADVEXPMEDBIOLA351992A35313A172355A235364A2249TAKEDAAA35SHIMADAHA35IMASEKIHA35ETA1A224CLINICALSIGNIFICANCEOFSERUMVASCULARENDOTHELIALGROWTHFACTORINCOLORECTALCANCERPATIENTSA172CORRELATIONWITHCLINICOPATHOLOGICALFACTORSANDTUMORMARKERSJA224ONCOLREPA352000A3572A172333A235338A22410KARAYIANNAKISAJA35SYRIGOSKNA35POLYCHRONIDISAA35ETA1A224CIRCULATINGVEGFLEVELSINTHESERUMOFGASTRICCANCERPATIENTSA172CORRELATIONWITHPATHOLOGICALVARIABLESA35PATIENTSURVIVALA35ANDTUMORSURGERYJA224ANNSURGA352002A352361A17237A23542A22411NIETHAMMERAGA35XIANGRA35BECKERJCA35ETA1A224ADNAVACCINEAGAINSTVEGFRECEPTOR2PREVENTSEFFECTIVEANGIOGENESISANDINHIBITSTUMORGROWTHJA224NATMEDA352002A35812A1721369137512TOMITAKA35IZUMIKA35OKABESA224ROXATIDINEA235ANDCIMETIDINEA235INDUCEDANGIOGENE
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