[生物医药论文精品a]survivin与肿瘤关系的研究进展

1DEVELOPMENTOFSURVIVINANDTUMORRESEARCHJIYUBIN1,2,3,LIUGUANGDA1,YULEI1,2,3,LIHAIJIAO1,YANGHAIFAN1，PANGLINLIN1A11CENTEROFRESEARCHANDDEVELOPMENTONLIFESCIENCESANDENVIRONMENTALSCIENCES,HARBINUNIVERSITYOFCOMMERCE,HARBIN150076,CHINA2INSTITUTEOFMATERIAMEDICAANDPOSTDOCTORALPROGRAMMEOFHARBINUNIVERSITYOFCOMMERCE,HARBIN150076,CHINA3ENGINEERINGRESEACHCENTEROFNATURALANTICANCERDRUGS,MINISTRYOFEDUCATIONA2ABSTRACTA0OBJECTIVESURVIVINWASFIRSTLYSEPARATEDINHYBRIDIZATIONOFEFFECTORCELLPROTEASERECEPTOR1EPR1CDNAINHUMANGENOMEBYYALEUNIVERSITYSAMBROSINIIN1997,WHICHISMEMBEROFTHEINHIBITOROFAPOPTOSISPROTEINSIAPSUNLIKEOTHERIAPPROTEIN,FOUNDDURINGEMBRYONICANDFETALDEVELOPMENT,SURVIVINWASCOMPLETELYDOWNREGULATEDANDUNDETECTABLEINNORMALADULTTISSUES,ANDBECAMEPROMINENTLYREEXPRESSEDINALLOFTHEMOSTCOMMONCANCERSITTHROUGHINCLUDESTHECYSTEINE/HISTIDINERODSHAPEDVIRALIAPREPETITIONSEQUENCEBACULOVIRALIAPREPEATSBIRSTHESTRUCTURETERRITORYDIRECTLYORINTERVENESCASPASESTHEFUNCTIONTODISPLAYINDIRECTLYITSANTIPERISHESWEAKLYTHEFUNCTION,SIMULTANEOUSLYITALSOISINTHECELLDIVISIONPROCESSTHECHROMOSOMETRAVELERPROTEINCHROMOSOMEPASSENGERPROTEINTHEREARETHREEAPPROACHESBYWHICHSURVIVININHIBITSTHEPROCESSINGOFAPOPTOSIS1INHIBITSPROCESSINGOFDOWNSTREAMEFFECTORCASPASE3,CASPASE7ANDCASPASE9INCELLRECEIVINGAPOPTOTICSTIMULS2WITHTHESMAC/DIABLOFUNCTION,SENDSTHEXIAPACTIVENESSTOINCREASE,XIAPTHROUGHDIRECTLYAFFECTSANDRESTRAINSITSFUNCTIONWITHCASPASES,ACHIEVEDRESTRAINSFUNCTIONWHICHPERISHESWEAKLY3THROUGHRESTRAINSP53THEFUNCTIONTOBLOCKPERISHESWEAKLYTHEPROCESSSURVIVINEXPRESSEDSPECIFICITYANDITSFUNCTIONMULTIPLICITYSURVIVINONLYEXPRESSESINTUMORTISSUESANDCANNOTBEFOUNDINNORMALTERMINALLYDIFFERENTIATEDTISSUESTHISKINDOFEXPRESSIONISBEENEXTREMELYLOWTHECELLCYCLESTRICTREGULATIONINTHEG1TIMEEXPRESSION,THESTIMEISG1TIME6TIMES,THEG2/MTIMEADVANCESTO40TIMES,DEMONSTRATEDITSEXPRESSIONHASTHEG2/MTIMEDEPENDENCESPECIFICITYITHASBIFUNCTIONOFINHIBITINGAPOPTOSISANDINVOLVINGINCELLCYCLECONTROLSURVIVINHASFOUNDINMOSTOFTUMORCELLSINRECENTLYRESEARCHESSURVIVINEXPRESSESGENERALLYINALLTUMORCELLLINEINTHEAMERICANSTATERUNCANCERRESEARCHINSTITUTEANTITUMORMEDICINESCREENINGPROCEDURE60DIFFERENTTUMORCELLS,INWHICHEXPRESSESINTHEMAMMARYGLANDCANCERCELLANDTHELUNGCANCERCELLHIGHLY,EXPRESSESINTHEKIDNEYCANCERLOWLYSURVIVINEXCEPTINTUMORCELLHIGHEXPRESSION,ATBREASTCANCER,TUMORINFRONTOFANDSOONENDOMETRIUMCANCER,CERVICALCANCERCANCERSINTHEPATHOLOGICALCHANGEHASTHEEXPRESSIONSURVIVINISOVEREXPRESSEDINEARLYMALIGNANT,WHICHBROKESTHEBALANCEOFPROLIFERATIONANDAPOPTOTIC,CAUSESTHEOCCURRENCEOFTUMOROBVIOUSLY,SURVIVINISCLOSELYRELATEDTOTHEUNCONTROLLEDGROWTH,CARCINOGENESIS,DEVELOPMENTANDTUMORIGENESISBECAUSESURVIVININTUMORORGANIZATIONSSPECIALEXPRESSIONANDPERISHESWEAKLYINTHESUPPRESSIONCELLANDADJUSTSINTHECELLDIVISIONTHEVITALROLE,CAUSESITTOBECOMEONETOHAVETHELATENTAPPLICATIONVALUETUMORDESIGNATEDOBJECTANDTHETUMORTREATMENTNEWTARGETSPOTSOTOINTRODUCETHERESEARCHOFSURVIVININTHEDEVELOPMENT,TREATMENTANDSITUATIONOFTUMORRECENTLYKEYWORDSA3SURVIVINCANCERRESEARCHADVANCE2SURVIVIN与肿瘤关系的研究进展季宇彬1,2,3，刘光达1，于蕾1,2,3，李海娇1，杨海帆1,庞琳琳1A41A5A6A7A8A9A10A11A12A13A14A11A15A16A17A14A11A18A19A20A21A22A5A6A7150076A232A5A6A7A8A9A10A11A24A25A18A19A26A27A28A29A14A18A30A31A32A22A5A6A71500763A33A34A35A36A37A24A25A38A39A40A30A41A18A19A20A21A22A42A43A44A5A6A7150076A45A46A47A48A49A50SURVIVINA511997A52A53A54A55A56A57A50AMBROSINIA58A59A60A61A62A63A64A65A66A67A681EFFECTORCELLPROTEASERECEPTOR1A69EPR1CDNAA70A71A72A73A74A75A76A50A77A78A79A80A81A82A83A84A85A86A87A50A69A51A88A89A64A65A90A91A74A92A93A94A95INHIBITOROFAPOPTOSISPROTEINS,IAPSA96A50A97A98A69A99A100A101A102A103A71A104A105A50A106A107A108A109A75A110A111A112A113A114A71A72A115A116A62A63A69A117A70A118A119A71A75A110A81A120A121A103A122A123A124A125A126A104A84A127A128A92A129A130A131A132A133A134A135A136A137A138A139/A75A138A139A50A140A141A142A143IAPA144A145A146A147A95BACULOVIRALIAPREPEATS,BIRSA96A148A149A150A151A152A153A154A152A155A156A157CASPASESA50A158A159A117A108A160A131A161A88A89A162A59A69A163A164A165A166A51A62A63A84A167A133A168A81A169A170A68A50A133A171A64A65A95CHROMOSOMEPASSENGERPROTEINA96A130SURVIVINA1723A173A174A175A90A176A62A63A50A88A891A132A133A151A152A90A176A88A89A177A178CASPASE3,CASPASE7,CASPASE9A58A50A179A180A172A117A181A182A62A63A183A89A133A1682A184A159A132A133A185SMAC/DIABLOA162A59,A186XIAPA179A180A187A188,XIAPA132A133A151A152A185CASPASESA162A59A189A90A176A131A158A159,A102A190A90A176A88A89A50A162A593A132A133A90A176P53A50A158A159A181A182A88A89A133A168A130SURVIVINA191A192A159A111A99A193A180A50A148A149A151A152A153A154A152A90A91CASPASEA194A195A153CASPASEA196A135A195A50A88A89A174A175A197A198A69A199A144A47A50A51A165A101A102A50A99A100A180A185A158A159A50A113A200A180A130SURVIVINA70A201A202A203A135A50A71A72A115A116A81A204A101A102A69A70A118A119A205A206A84A207A50A97A52A75A110A153A62A63A81A196A101A102A208A209A131A204A101A102A210A115A116A62A63A194A195A50A99A100A180A130A211A212A101A102A67A62A63A213A128A214A215A183A216A70G1A128A101A102A217A218A69SA128A219G1A128A506A220A69G2/MA128A221A187A204A22240A220A69A208A209A131A101A102A223A135G2/MA128A194A195A50A99A100A180A130SURVIVINA223A224A62A63A213A128A183A216A104A88A89A183A225A226A144A158A159A130A227A52A87A50A228A229A230A231A101A232A69SURVIVINA70A56A233A115A116A62A63A234A81A235A70A101A102A130A236A237A237A238A239A240A228A229A203A161A115A116A241A242A79A80A168A146A81A5060A243A196A163A115A116A62A63A81,SURVIVINA70A203A135A115A116A62A63A234A81A244A245A101A102,A131A81A70A246A123A239A62A63A104A247A239A62A63A81A101A102A248A204,A70A249A239A81A101A102A248A218A130SURVIVINA191A192A70A115A116A62A63A81A204A101A102,A70A246A123A239A124A92A129A250A251A239A124A129A252A239A58A115A116A50A239A253A142A254A81A255A135A101A102A130A70A62A63A25A254A0A128SURVIVINA213A133A1A101A102,A215A2A192A62A63A187A217A104A88A89A197A154A50A3A4,A220A186A115A116A50A108A217A130A184A121SURVIVINA73A74A185A115A116A62A63A217A28A5A216A124A115A116A108A217A124A108A63A111A112A115A116A248A205A6A97A7A234A8A9A130A53A103SURVIVINA70A115A116A75A110A81A50A99A100A101A102A112A131A70A90A91A62A63A88A89A112A183A225A62A63A84A167A81A50A144A47A162A59A69A228A131A97A219A10A243A223A135A11A70A61A59A12A13A50A115A116A14A15A242A104A115A116A16A17A50A18A19A20A130A240A21SURVIVINA227A52A70A115A116A108A217A124A108A63A124A16A17A81A50A228A229A235A22A23A111A24A26A130A7A225A27A48SURVIVINA249A115A116A249A228A229A183A63SURVIVINA511997A52A53A54A55A56A57A50AMBROSINIA58A59A60A61A62A63A64A65A66A67A681EFFECTORCELLPROTEASERECEPTOR1A69EPR1CDNAA70A71A72A73A74A75A76A50A77A78A79A80A81A82A83A84A85A86A87A50A69A51A88A89A64A65A90A91A74A92A93A94A95INHIBITOROFAPOPTOSISPROTEINS,IAPSA96A50A97A98A69A99A100A101A102A103A71A104A105A50A106A107A108A109A75A110A111A112A113A114A71A72A115A116A62A63A69A117A70A118A119A71A75A110A81A120A121A103A122A123A124A125A126A104A84A127A128A92A129A130A131A132A133A134A135A136A137A138A139/A75A138A139A50A140A141A142A143IAPA144A145A146A147A95BACULOVIRALIAPREPEATS,BIRSA96A148A149A150A151A152A153A154A152A155A156A157CASPASESA50A158A159A117A108A160A131A161A88A89A162A59A69A163A164A165A166A51A62A63A84A167A133A168A81A169A170A68A50A133A171A64A65A95CHROMOSOMEPASSENGERPROTEINA96A130A53A103SURVIVINA70A115A116A75A110A81A50A99A100A101A102A112A131A70A90A29A30A31A32A33A39A34A35A36A37A38A40A41A42A43A44A45A46D200610A47A48A49A50A51A52A53A54A551956,A56,A57A58A59A57A58A60A59A61A62,A57A58A64A65A66,A67A68A69A70A52A71A72A73A74A75A67A681A76A77A48A49A78TEL045184844242EMAILYULEIHRBCUEDUCN3A79A80A81A82A83A84A85A86A80A81A87A88A89A90A91A92A93A94A95A96A97A98A99A100A101A102A103A104A105A106A94A107A108A90A109A110A111A112A113A114A109A110A115A116A90A117A118A119A1201SURVIVIN的结构特点SURVIVINA121A122A123A124A125142A198A126A127A128,A129IAPA130A131A132A133A134A135A136A137A138A139A140A141A142A143A144A145A146A147A148A149A150,A151A152A229A153IAPA154A155A147A156A157A139A140A158A159A160A161A162A163A164A139A140BACULOVIRUSIAPREPEAT,BIR,A165A166A167A168A169A170A171A172A167A163A173A174A175A148A176A177A178A179A177PRO33A180TRP67A181CYS84,A182A184CASPASE3A139A185A169A170A165A186A157A187A177A188A189A190A191A192A193A139A140A194A195A196A197A199A200A139A140A201SURVIVINA177A202A203A204A205A206A207A208A20917Q25,A177A202A210A221145KB,A2114A153A212A173A214A216A218A1803A153A219A222A214A216A218A,B,CA1813A153A223A166A218A224A226,A214A216A218A181A223A166A218A227A230A224A185A231A226SURVIVINMRNAA232A233A234A236A237A140A209A201SURVIVIN2BMRNAA238A239A241A242A223A166A2182A243A214A216A218B,A244A245A246A216A247A248A250SURVIVIN2BA149A150A251A252A160A203A204A205A253A254A209,A255A25A171A172A0A1A2A3A4A5,A6A253A254A209A171A172A23A7A148A39A8A202A218A201A25A9A10A171A172A41A11A12A13A119,A253A254A209A2SURVIVINA45A14A15A16A177A0A1A251A2,A169A170CASPASESA113A182A17A194A169A170A171A172A203A204A205A253A254A209A2A148SURVIVIN2BA176A18A182A19A20A21A22A253A254A209A2SURVIVINA15A16A63A24A165A49A250A171A172A148A174A175A201SURVIVINEX3MRNAA190A26A214A216A2183,A27A241A242A204A205A0A1A51A223,A244A245A246A216A247A248A33A18A139A253A254A209A181A0A1A51A223A205A167A53A28A4A5A252A1671/5A108A55A154A26A229A252A204A205A253A254A209A2A201A166A214,SURVIVINPTEX2/3,SURVIVIN2A181SURVIVIN3BA29A232A153SURVIVINA237A140A209A56A63A30A255A25A0A1A171A172A31A32A2A63A24A227A230A174A175A2012SURVIVIN与细胞凋亡SURVIVINA178A34A35A36A37A38A40A42A43A44A46A40A47A48A50A52A54A85SURVIVINA1273A128A57A58A59A60A35A36A61A44A461A87A62A64A65A59A60A44A46A66A67A68CASPASE3,CASPASE7,CASPASE9A69A70A71A72A73A74A75A76A77A78A79A80A81A822A83A84A86A81A88SMAC/DIABLOA117A89,A141XIAPA71A72A134A90,XIAPA86A81A91A92A88CASPASESA117A89A93A94A131A95A96A84,A97A98A94A131A99A80A70A117A893A86A81A94A131P53A70A96A84A75A76A99A80A81A82A100A101A77A78A102A103A104A105A70A81A82A106,A102A103A168A107A109A110A72A168A107A111A112CELLCYCLEDEPENDEDKINASE,CDKA114A115A116A118A77A78A102A103A118A120A70A117A89,P21A83A121A94A122CDKA70A117A89,A73A74A123A77A78A102A103A124A98A145A72A125A126A72A79A135A100SURVIVINA83A88P21A168A107A129A130A132A106A133A136A137,A228P21A138A140A101A106A133A136A137,A142A143A126A72A79A144,A77A78A102A103A146A147A100SURVIVINNA148A70BIRA149A83A88CASPASE3A150A151A117A89A73A74A94A122A99A80A152A77A78A153A155A156A157A158A134A159A160,SURVIVINMRNAA161A97A162SURVIVINA168A107A96A84A163A98A94A122A164A253A165A167RNAA169A170,A171A172A173A174A175A179,CASPASE3A180A181A182A183A101A99A80A184A185,P21A186A187A75A188A77A78A102A103,A77A78A102A103A189A114A190A191A192A100A77A78A99A80A88A77A78A102A103A101A193A194A70A79A135A165A167SURVIVINA168A107A70A79A144A195A150A151A196A226A197A130,A198A199A77A78A153A194A190A200A201A202A70A155A156A100SURVIVINA203A204A84A121A206A207A72A70A129A208A91A92A162A209A92A94A122CASPASEA109A110A162CASPASEA153A210A110A70A99A80A184A185A211A212A213A214A180A1564A70A215A216A161A97A70A206A217A72A88A96A84A70A218A219A72A100A220A221A213SURVIVINA101A222A223A224A210A70A225A227A229A230A106A231A161A97A213A101A145A232A233A234A165A235A70A236A237A238A239A162A77A78A106A153A161A97A240A241A95A231A161A97A123A229A230A77A78A109A110A70A206A217A72A100A95A187A213A242A243A161A97A163A77A78A102A103A244A245A79A135A101G1A103A161A97A246A247A213SA103A248G1A103A706A249A213G2/MA103A254A134A231A25540A249A213A240A241A95A161A97A56A210G2/MA103A109A110A70A206A217A72A1003SURVIVIN与肿瘤A182A0A1A2A3A4A5A6A7A8A24SURVIVINA25A9A10A11A12A13A14A15A16A17A25A7A18A85A191A19A19A20A21A22A3A4A23A116A26A27A28A29A30A31A32A33A34A3560A198A36A37A26A27A38A39A34,SURVIVINA40A41A42A26A27A38A39A43A34A44A45A46A47,A86A34A40A48A49A50A38A39A51A52A50A38A39A34A46A47A53A54,A40A55A50A34A46A47A53A57A58SURVIVINA146A59A40A26A27A38A39A34A54A46A47,A40A48A49A50A79A60A61A62A63A50A79A61A84A50A64A26A27A35A50A65A66A67A34A68A42A46A47A58RYAN1A64A69ELISAA89A90A70420A92A71A72A73A48A49A50A74A90A75A76A34SURVIVINA77A78,A86A34378A9290A80SURVIVINA94A73A58A95A42A183A81A82A83A8734A167A61A84A50A38A39A96A8825A92A61A84A50A91A97A34SURVIVINA46A47A68A94A73,A93A40A98A99A61A84A75A76A88A50A100A98A99A75A76A34A101A46A47A102A73A58A40A38A39A103A67A104A105SURVIVINA213A106A107A46A47,A215A108A59A38A39A109A110A51A111A112A113A114A35A115A117,A220A118A26A27A35A72A110A58A139A119SURVIVINA120A121A122A26A27A38A39A110A123A124A125A79A26A27A72A110A79A72A126A127A88A26A27A53A128A129A130A131A43A132A133A5831SURVIVINA134A135A136A135A136SURVIVINA137A138A194A140A141A142A143A144A145A147A148A149A150A151A152A153A154A155A156A157A185A158A159A160ITO3A161A162A163A164A165A166A155A168A169A170A171A172A173A17420A175A176A177A165A178A159L4A17570A179A180SURVIVINA155A181A184A186A187A174A188A186A187A189A190A155A192A193A195A161A1965A179A19795A179A249A188A199A180A155A177A200A165A178A201A176A202A166A155A176A203A165A178A159A204A205SURVIVINA155A186A187A160MORINAGA4A161A206A162A207A208A209A210RTPCRA168A169A211A21240A175A176A177A214A216A217A177A200A165A178A218A219A175A221A222A176A165A178A159SURVIVINMRNAA155A186A187A174A176A177A165A178A159SURVIVINMRNAA155A186A187A223A224A225587073LOGA226A227A192/MGA228RNAA174A216A217A177A200A165A178A225479096A174A221A222A176A165A178A225195044A249A176A177A165A178SURVIVINMRNAA155A186A187A229A230A231A232A192A233A234A216A235A236R0537A174P0001A237,A229A238A239A232A192A233A221A216A235A236R0433A174P0005A237,A229A240A241A242A243A244A245A214A165A178A246A244A247A248A250A216A235A236P005A237A174SURVIVINMRNAA186A187A223A224A251A155A252A253A180A254A255A155A5A0A120P003A160IKEGUCHI5A161A217A162A156A119A207A208A209A210RTPCRA168A169A211A21252A175A176A189A190A177A252A253A2015A175A92A176A189A190A177A252A253A176A203A227A1A2A97SURVIVINMRNAA155A186A187A174A172A173SURVIVIN/GAPDHA122A232A3A176A177A165A178A159A248A250A251A151A92A176A177A165A178A174SURVIVIN/GAPDHA122A232A229A240A241A189A190A230A231A233A234A216A235A174A229A240A241A189A190A155A238A239A134A184A233A221A216A235A174A188A38SURVIVIN/GAPDHA122A232A251A155A240A241A252A253A100A172A155A123A4A254A11A160SURVIVINA139A6A225A7A8A125A9A155A240A241A127A10A12A137A232A2A160A130A13A170A171A186A248A174SURVIVINA180A139A90A6A225A176A177A12A137A214A236A14A132A137A214A112A212A176A177A100A172A214A132A137A112A133A155A7A8A232A2A174A188A38A139A15A6A225A240A241A5A16A17A236A18A19A155A205A2A16032SURVIVINA21A22A23A24A21A22A23A24A182A25A26A27A28A29A30A31A32SURVIVINA33A34A35A62A36A135A37A39A194A40A41A42A43A44A45A46A47A48A58A49A50A37A39A40A41A51A72A52A53A54A37A39A194A40A41A55A56A117A59A57A60A56A61A43A141A48A72A159A48A51A63A140A37A39A194A43A40A41A55A64A142A65A225A85A35A66A37A39A194A118A67A43A57A60A68A69A56A145A42A70A71A51A57A60A56A61A146A73A51A40A41A56A117A211A135A74A75A146A48A51SURVIVINA43A94A135A44A45A76A146A48A51A72A77A58A57A60A56A61A51A40A41A56A117A74A75A140A37A39A194A43A78A79A226A80A81A225A51A148A46SURVIVINA43A48A44A45A78A82A83A84A86A87A48A43A149A88A135A59A89A91A78A79A51A151A82SURVIVINA35A62A36A135A37A39A194A43A70A93A70A95A96A74A42A98A147A99A101A102A103A51A104A105A106A96A107A108A62A36A135A37A39A194A109A110A111A113A72A66A37A39A194A43A70A95A59A149A88A98A99A101A102A103A51SURVIVINA33A34A104A114A102A115A116A121A78A79A43A86A103A124A233A126A128A85KLEINBERG2A129A131A136A138A70A135A37A39A194A42SURVIVINA143A144A44A45,A70A71A150A152A153A154A155A156A35A157,A83A84A109A110SURVIVINA94A135A76A210A3590A114A62A85SUIL6A129A158A160A37A39A62A36A135A83A84A42SURVIVINA143A144A43A44A45A51A161A44A45A76A35A91A135A83A84A42A115212A51A162A163A135A83A84A115478A51A37A39A194A115511A51A72A35A49A50A37A39A62A36A40A41A42A164A158A160A165SURVIVINA43A44A45A85A166A37A39A91A135A83A84A165A162A163A135A167A211A135A83A84A51SURVIVINA43A44A45A168A169A159A48A51A170A171A172A173A35A128A174A194A175A155A176A177A70A135A170A178A179A180A51A181A183A184A155A129A42A158A160A185SURVIVINA43A44A45A51A186A160SURVIVINA35A83A84A211A135A176A43A187A61A188A86A44A45A51A189A190A128A191A192A190A83A84A193A195A44A142A43A153A196A85SURVIVINA43A96A44A45A35A37A39A91A135A197A162A163A135A167A211A135A83A84A43A153A196A42A104A105A98A99A101A102A103A85SURVIVINA102A115A128A198A199A70A71A43A111A113A107A108A143A144A35A37A39A194A42A48A44A45A51A200A86A107A108A109A110A111A113A59A192A190A109A110A159A201A43A202A135A51A66A62A36A135A37A39A194A43A70A93A70A95A86A99A101A102A103A51A140A37A39A194A43A78A79A225A203A226A80A8533SURVIVINA204A205A206A207A205A206A208A209A212A213A214A215A216A217A218A219A220A221A222A223A224A228A229SURVIVINA230A231A234A235A237A238A239A240A241A242A243A244A245A246A253A237A247A248A249A250A251A252A254A251A230A255A237A228A172A103A173A151A0A174A85A175A1A2A185A3A237SAITCH7A13A4PCRSSCPA89A1657A92A84A207A5A6A7A8A2526A92A47A84A205A9A5A6A7A8A25225A92A84A207A5A10A11A12A178A6717A92A47A84A205A9A5A10A11A12A178A250A133A241A242A237A103A173A25A14A15A241A242A16A5A6A7A8A67A5A10A11A12A178A36A17A15SURVIVINMRNAA16A230A231A85TAKAI8A13A18A19A102A20A10A11A30A145A89A30A14531A92A47A84A205A9A5A2120A92A73A22A47A84A205A9A36SURVIVINA16A230A231A23A24A237A63A26A25A73A22A47A84A205A9A10A11A36A237SURVIVINA156A27A109A230A231A237A142A72A83051A252A30A39A830158,A234A69A110A25A47A84A205A9A5A10A11A16A7A51A21A7A59A36A237SURVIVINA230A231A120A28A29A237A118A31A63A26A10A11A36SURVIVINA230A231A254A251A120A16A29A32A33A47A84A205A9A5A16A139A34A30A83A252A10A11A35A30A117A252A37A179A38A67A47A84A180A40A161/2A237A139A34A112A41A13A42A43A234A235A237A127A44A170A45SURVIVINA37A46A48A129A137A47A84A205A9A5A16A12A182A197A237A49A0A165A112A41A250A133A132A137A85LEHNER9A13A241A242A4RTPCRA89A50A52A73A22A47A84A205A9A10A11A21A47A84A205A9A243A53A5A36SURVIVINMRNAA16A230A231A237A103A173A63A26A25A14A15A12A178A36A237A17A0A50A52A54A55A230A231A85TARKOWSKYA13A249A102A20A10A56A89A50A52A47A84A2056A9A5A252A142A57A19A58A47A84A205A9A10A11A36SURVIVINA60A61A230A231A30A183A45100,73A237A208A62A163A184A29A159A41A62A237A49A33A140A64A65A66A16A142A68A163A184A234A235A85SURVIVINA33A47A84A207A5A112A41A16A235A8A70A71A74A75A15A1A2A185A3A237A238A239A240A185A3A243A244A245A246A253A49A247A45A76A77A186A241A242A237A47A84A207A5A16A112A41A78A79A77A186A189A247A237A76A77A186A241A242A190A249A218A80A78A79A77A186A237A191A103A173A151A192A0A174A85A235A159SURVIVINA33A47A84A207A5A112A41A235A8A16A247A77A186A241A242A81A208A82A86A234A235A185A3A8534SURVIVINA87A88A90A88A90SURVIVINA91A193A194A93A94A95A96A97A98A99A131A100A101A104A91MRNAA105A106A107A108,A111A113A114A115A116A119A121A122SURVIVINA91A193A194A123A124A93A125A95A96A104KAZUHITO10A107A108A147107A126A193A194A128A194A130A123A124A196A194A123A124A134A1353CMSURVIVINMRNAA94A95A96A136A138A141A121A122A91A194A128A194A130A123A124MRNAA95A96A94A143A144A146A148A149A96782A128944A136A150A152A