辅酶一(NAD)与老年化疾病PPT参考课件

1、,Age-related diseases and cancer,Age-related diseases,COENZYME I,P-1,2020/9/1,CONTENTS,A. NAD biosynthetic pathways and metabolism B. NAD consuming enzymes in health and disease C. Age-related diseases and cancer D. Mechanisms of NAD Precursors in humans and animal models E. NAD and the hallmarks of

2、 aging,P-2,2020/9/1,A.,NAD biosynthetic pathways and metabolism,P-3,2020/9/1,NAD biosynthetic pathways and metabolism,Eric Verdin. (2015). Special Section 350（6265）: 1208-1213.,P-4,NAD biosynthetic pathways and metabolism in different cellular compartments.,2020/9/1,B.,NAD consuming enzymes in healt

3、h and disease,P-5,2020/9/1,NAD consuming enzymes in health and disease,E F. Fang,. (2017). NAD+: a key metabolic regulator with great therapeutic potential: 1120-1143.,P-6,NAD availability can influence the activity of three groups of master regulator enzymes the sirtuins, the PARPs and cyclic ADP-r

4、ibose synthases. Each group of enzymes regulate many biological processes and can thus couple changes in NAD levels with a wide range of physiological responses.,2020/9/1,C.,Age-related diseases and cancer,P-7,2020/9/1,1980s,1930s,P-8,Age-related diseases and cancer could be the consequence of a dec

5、line in NAD+ concentrations,Amanda Garrido (2017). Trend in cancer 181: 181-199.,Age-related diseases and cancer,Metabolic syndrome including cardiovascular disorders, type 2 diabetes and obesity, Neurodegenerative diseases such as Alzheimer and Parkinsondiseases, arthritis, and osteoporosis, and ca

6、ncer are some of the diseases that commonly affect human health during aging.,2020/9/1,D.,Benefits and mechanisms of NAD precursors in humans and animal models,P-9,2020/9/1,Benefits and mechanisms of NAD precursors in humans and animal models,GSultani. (2017). Trends in Molecular Medicine23（10）: 900

7、-918,P-10,2020/9/1,Benefits and mechanisms of NAD precursors in humans and animal models,GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918,P-11,2020/9/1,Benefits and mechanisms of NAD precursors in humans and animal models,GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918,P-1

8、2,2020/9/1,E.,NAD and the hallmarks of aging,P-13,2020/9/1,NAD and the hallmarks of aging,GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918,P-14,2020/9/1,NAD and the hallmarks of aging,GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918,P-15,2020/9/1,NAD and the hallmarks of aging,GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918,P-15,2020/9/1