图像分析法在化妆品临床测试中的运用

1、1,眼见为实：图像分析法在化妆品临床测试中的运用 瞿欣 亚什兰公司 特种添加剂部门，上海研发中心 上海, 中国 November 7, 2013,Cosmetics R,18,均匀肤色,所画直线必须穿过包括老年斑的区域，通过对比斑点和周围皮肤的L*值来显示皮肤的均匀性。,0 天,0 天,42d,42d,42d,42 天,42 天,19,皮肤皱纹,使用软件的“line profile”功能对特定区域的皱纹进行宽度和深度的定量分析。,20,皮肤粗糙度,提取交叉偏振照片中的L*图像，选择鼻翼附近容易毛孔粗大的区域作为分析区域。 使用软件中的“计数/尺寸”功能来计算皮肤毛孔的数目，面积等。 比较安慰剂

2、和活性物一侧使用产品前后毛孔数目，面积等的变化。,21,部分实验数据,22,C 图像示例,23,背景调查： 以前不怎么用护肤品，理想中护肤品：滋润有光泽，改善皱纹，淡化色斑，均匀肤色，有一定的美白效果。,年龄：54 性别：男 职业：销售人员 参加测试时间：2012年12月 皮肤特征：干燥，粗糙，皱纹较多，肤色不均匀，有时是敏感性皮肤。冬天干燥冷风吹来有痛感。,示例 1,24,Prolixir ICE 活性混合物对皮肤健康的改善情况,用后感受： “ 皮肤变白，变亮，更光滑细致。眼角皱纹几乎没有了，好像被撑平了一样，这个挺出乎意料的。以前不怎么用护肤品，从来没想到会有这么好的效果”,25,背景调查

3、： 有时感觉皮肤敏感，理想中护肤品：去除暗哑，黄气，美白皮肤，淡化色斑，提亮肤色，有一定的舒敏功效。,年龄：48 性别：女 职业：公司职员 参加测试时间：2012年12月 皮肤特征：暗哑，无光泽，有色斑，有时感觉皮肤敏感，皮肤耐受力相对较差。,示例 2,26,用后感受： “原来偏黄的皮肤变白变亮了,周围朋友同事发现皮肤变化很大，询问使用什么产品，暗黄减轻了很多. 皱纹减少了很多,就像长胖了,皱纹被撑开了,真的非常喜欢你们的产品,希望可以买到类似的产品.”,Prolixir ICE 活性混合物对皮肤健康的改善情况,27,致谢：,亚什兰（上海）护肤研发团队,（左）凌峰，陈志华，赵云珊，赵小敏，李亚

4、男，瞿欣（右） (left) Ling Feng, CHEN Zhi-hua, Zhao Yunsan, ZHAO Xiao-min, Li Ya-nan, QU Xin (Right),亚什兰（美国）研发中心 Germain Puccetti Linda Foltis,Disclaimer,The information contained in this presentation and the various products described are intended for use only by persons having technical skill and at thei

5、r own discretion and risk after they have performed necessary technical investigations, tests and evaluations of the products and their uses. This material is for informational purposes only and describes the scientific support for the use of the products described herein as an ingredient in cosmeti

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