NOD1-antagonist-2-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENOD1antagonist-2Cat.No.:HY-170447分⼦式:C₂₁H₁₃Cl₂F₂N₃O₅S₂分⼦量:560.38作⽤靶点:NOD-likeReceptor(NLR)作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性NOD1antagonist-2(compound66)⼀种⼝服有效的选择性拮抗剂，可抑制⼈类和⼩⿏的NOD1。NOD1拮抗NOD1antagonist-2(compound66)可以阻断NOD1诱导的NF-κB和MAPK途径。IC50&TargethNOD1mNOD10.8nM(IC50,inHEK293cells)32nM(IC50,inHEK293cells)体外研究NOD1antagonist-2(compound66)demonstratespromisingantagonisticactivityagainstbothh/mNOD1-inducedNF-κBactivationinHEK293cells(IC50=0.8nMand32nM,respectively)[1].NOD1antagonist-2(compound66,0.1,1μM)markedlyinhibitstheincreasesinp-RIP2,p-p65,p-p38,andp-JNKofbothTHP-1cellsandmBMDMs,demonstratingitsefficacyinmodulatingNOD1-inducedsignalingpathways[1].体内研究NOD1antagonist-2(compound66,orally)inhibitstheexpressionofinflammatorycytokines(IL-6,TNF-α)andchemokines(CXCL1,CXCL8)inimmuneandepithelialcells,aswellasinflammatorycytokines(KC,IL-6)inaH.pylori-inducedmurinemodel[1].REFERENCES[1].XinhuaLiu,etal.SelectivelyAntagonizingtheNOD1-MediatedInflammatorySignalingPathwayMitigatestheGastricInflammationInducedbyHelicobacterpyloriInfection.JMedChem.2024Dec26;67(24):22145-22167.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a