Vigabatrin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEVigabatrin(Standard)Cat.No.:HY-15399RCASNo.:68506-86-5分子式:C₆H₁₁NO₂分子量:129.16作用靶点:GABAReceptor;GABAReceptor作用通路:MembraneTransporter/IonChannel;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Vigabatrin(Standard)是Vigabatrin的分析标准品。本产品用于研究及分析应用。Vigabatrin(γ-Vinyl-GABA)，一种抑制性神经递质GABA乙烯基衍生物，是一种具有口服活性且不可逆的GABA转氨酶(GABAtransaminase)抑制剂。Vigabatrin是一种抗癫痫剂，通过抑制GABAtransaminase对GABA的分解代谢来增加脑中GABA的水平。REFERENCESBroeer,etal.Vigabatrinforfocaldrugdeliveryinepilepsy:Bilateralmicroinfusionintothesubthalamicnucleusismoreeffectivethanintranigralorsystemicadministrationinaratseizuremodel.NeurobiologyofDisease(2012),46(2),362-376.Gaily,EijaVigabatrinmonotherapyforinfantilespasms.ExpertReviewofNeurotherapeutics(2012),12(3),275-286.JakobPlum,etal.Theanti-epilepticdrugsubstancevigabatrininhibitstaurinetransportinintestinalandrenalcellculturemodels.IntJPharm.2014Oct1;473(1-2):395-7.Broeer,etal.Vigabatrinforfocaldrugdeliveryinepilepsy:Bilateralmicroinfusionintothesubthalamicnucleusismoreeffectivethanintranigralorsystemicadministrationinaratseizuremodel.NeurobiologyofDisease(2012),46(2),362-376.Gaily,EijaVigabatrinmonotherapyforinfantilespasms.ExpertReviewofNeurotherapeutics(2012),12(3),275-286.JakobPlum,etal.Theanti-epilepticdrugsubstancevigabatrininhibitstaurinetransportinintestinalandrenalcellculturemodels.IntJPharm.2014Oct1;473(1-2):395-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021