Olanzapine-hydrochloride-LY170053-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOlanzapinehydrochlorideCat.No.:HY-14541ACASNo.:783334-36-1Synonyms:LY170053hydrochloride分⼦式:C₁₇H₂₁ClN₄S分⼦量:348.89作⽤靶点:5-HTReceptor;DopamineReceptor;mAChR;AdrenergicReceptor;Autophagy;Mitophagy;Apoptosis作⽤通路:GPCR/GProtein;NeuronalSignaling;Autophagy;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Olanzapinehydrochloride⼀种选择性的、具有⼝服活性的单胺能拮抗剂，⾼亲和⼒结合5-羟⾊胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapinehydrochloride⼀种⾮典型的抗精神病剂[1][2]。户使⽤本产品发表的科研⽂献•NatCommun.2022Nov10;13(1):6796.•ActaPharmacolSin.2021May11.•BrainPathol.2024Sep18:e13306.•FrontPharmacol.12August2022.•DrugDevRes.2024Jun;85(4):e22225.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].APPROVEDAGREED-UPONLABELING.[2].OlanzapineforInjection,powder,forsolutionforintramuscularuse.[3].VucicevicL,etal.Autophagyinhibitionuncoverstheneurotoxicactionoftheantipsychoticdrugolanzapine.Autophagy.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2014;10(12):2362-78.[4].Karpel-MasslerG,etal.Olanzapineinhibitsproliferation,migrationandanchorage-independentgrowthinhumanglioblastomacelllinesandenhancestemozolomide'santiproliferativeeffect.JNeurooncol.2015Mar;122(1):21-33.[5].CoccurelloR,etal.Chronicadministrationofolanzapineinducesmetabolicandfoodintakealterations:amousemodeloftheatypicalantipsychotic-associatedadverseeffects.Psychopharmacology(Berl).2006Jul;186(4):561-71.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0