Foretinib-phosphate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEForetinibphosphateCat.No.:HY-10338ACASNo.:1226999-07-0分⼦式:C₃₄H₄₀F₂N₄O₁₄P₂分⼦量:828.64作⽤靶点:c-Met/HGFR;VEGFR作⽤通路:ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Foretinibphosphate⼀种具有潜在抗肿瘤活性的⼝服⽣物可利⽤⼩分⼦。Foretinibphosphate能够选择性地抑制肝细胞⽣长因⼦（HGF）受体c-MET和⾎管内⽪⽣长因⼦受体2（VEGFR2），从⽽可能抑制肿瘤的⾎管⽣成、肿瘤细胞增殖和转移。Foretinibphosphate在肺癌细胞中显⽰出与cabozantinib不同的抗癌活性，并且对MEK1/2、FER和AURKB等靶点具有更强的抑制作⽤。户使⽤本产品发表的科研⽂献•CancerDiscov.2021Jan;11(1):126-141.•NatBiomedEng.2018Aug;2(8):578-588.•SciTranslMed.2018Jul18;10(450).pii:eaaq1093.•CellChemBiol.2018Feb15;25(2):206-214.e11.•CellRepMethods.2023Oct23;3(10):100599.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].QianF,etal.Inhibitionoftumorcellgrowth,invasion,andmetastasisbyEXEL-2880(XL880,GSK1363089),anovelinhibitorofHGFandVEGFreceptortyrosinekinases.CancerRes,2009,69(20),8009-8016.[2].KataokaY,etal.Foretinib(GSK1363089),amulti-kinaseinhibitorofMETandVEGFRs,inhibitsgrowthofgastriccancercelllinesbyblockinginter-receptortyrosinekinasenetworks.InvestNewDrugs,2011.[3].EderJP,etal.AphaseIstudyofforetinib,amulti-targetedinhibitorofc-Metandvascularendothelialgrowthfactorreceptor2.Clin1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECancerRes,2010,16(13),3507-3516.[4].DivergentPolypharmacology-DrivenCellularActivityofStructurallySimilarMulti-KinaseInhibitorsthroughCumulativeEffectsonIndividualTargetsMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-