Flunixin-Sch-14714-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFlunixinCat.No.:HY-121046CASNo.:38677-85-9Synonyms:Sch14714分⼦式:C₁₄H₁₁F₃N₂O₂分⼦量:296.24作⽤靶点:COX作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Flunixin⼀种环氧化酶(COX)抑制剂，对COX-1和COX-2的IC50值分别为0.55和3.24μM，其具有抗炎作⽤。IC50&TargetCOX-1COX-20.55μM(IC50)3.24μM(IC50)体外研究flunixinmeglumine(10-1000μM,2h)inhibitslipopolysaccharide(LPS)-inducedactivityofinduciblenitricoxidesynthase(iNOS)inRAW264.7murinemacrophages[2].flunixinmeglumine(10-1000μM,2h)inhibitslipopolysaccharide-inducedactivationofnuclearfactorkappaB(NfκB)inRAW264.7murinemacrophages[2].CellViabilityAssay[2]CellLine:RAW264.7murinemacrophagesConcentration:10,100,300,and1000μMIncubationTime:2hoursResult:InhibitedLPS-inducednitricoxidereleaseatconcentrationsbetween100and1,000µM(P=0.01).体内研究Flunixinmeglumine(intravenousinjection;1.1mg/kg;once)treatmentinhibitstheformationofexudatePGE21/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEandserumTXB2[1].AnimalModel:MalesheepinjectedwithCarrageenan[1]Dosage:1.1mg/kgAdministration:Intravenousinjection;1.1mg/kg;onceResult:InhibitedCarrageenan-inducedexudatePGE2formation(Emax,100%,IC50,max,100%,IC50,17nM)forupto32h.REFERENCES[1].ZCheng,etal.Measurementofcyclooxygenaseinhibitioninvivo:astudyoftwonon-steroidalanti-inflammatorydrugsinsheep.Inflammation.1998Aug;22(4):353-66.[2].ClareEBryant,etal.EvaluationoftheabilityofcarprofenandflunixinmegluminetoinhibitactivationofnuclearfactorkappaB.AmJVetRes.2003Feb;64(2):211-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379