3-Demethylthiocolchicine-生命科学试剂-MCEVIP

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE3-DemethylthiocolchicineCat.No.:HY-W355463CASNo.:87424-25-7分子式:C₂₁H₂₃NO₅S分子量:401.48作用靶点:Microtubule/Tubulin作用通路:CellCycle/DNADamage;Cytoskeleton储存方式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:125mg/mL(311.35mM;Needultrasonic)SolventMass1mg5mg10mgConcentration制备储备液1mM2.4908mL12.4539mL24.9078mL5mM0.4982mL2.4908mL4.9816mL10mM0.2491mL1.2454mL2.4908mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。BIOLOGICALACTIVITY生物活性 3-Demethylthiocolchicine是一种Colchicine(HY-16569)类似物，具有广谱抗肿瘤活性。3-Demethylthiocolchicine在阻断酪蛋白诱导的淀粉样变性，微管结合和抗炎作用方面与Colchicine具有相同的作用和活性，且毒性明显较低。REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEKerkesP,etal.Synthesisandbiologicaleffectsofnovelthiocolchicines.3.EvaluationofN-acyldeacetylthiocolchicines,N-(alkoxycarbonyl)deacetylthiocolchicines,andO-ethyldemethylthiocolchicines.Newsynthesisofthiodemecolcineandantileukemiceffectsof2-demethyl-and3-demethylthiocolchicine[J].Journalofmedicinalchemistry,1985,28(9):1204-1208.WolachB,etal.Colchicineanalogues:effectonamyloidogenesisinamurinemodeland,invitro,onpolymorphonuclearleukocytes[J].Europeanjournalofclinicalinvestigation,1992,22(9):630-634.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fa