Vardenafil-hydrochloride-trihydrate-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVardenafilhydrochloridetrihydrate(Standard)Cat.No.:HY-B0442BRCASNo.:330808-88-3分⼦式:C₂₃H₃₉ClN₆O₇S分⼦量:579.11作⽤靶点:EndogenousMetabolite;Phosphodiesterase(PDE)作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Vardenafil(hydrochloridetrihydrate)(Standard)Vardenafil(hydrochloridetrihydrate)的分析标准品。本产品⽤于研究及分析应⽤。Vardenafilhydrochloridetrihydrate⼀种具有⾼选择性和⼝服活性的磷酸⼆酯酶5(PDE5)抑制剂，IC50为0.7nM。Vardenafilhydrochloridetrihydrate对PDE1、PDE6的IC50为180nM，11nM，对PDE3、PDE4的IC50>1000nM。Vardenafilhydrochloridetrihydrate⾮竞争性地抑制环磷酸鸟苷(cGMP)⽔解，从⽽提⾼cGMP⽔平。Vardenafilhydrochloridetrihydrate可⽤于研究勃起功能障碍、肝炎、糖尿病等疾病。IC50&TargetIC50:0.7nM(PDE5);180nM(PDE1);11nM(PDE6);>1000nM(PDE3,PDE4)[1]REFERENCES[1].GresserU,etal.Erectiledysfunction:comparisonofefficacyandsideeffectsofthePDE-5inhibitorssildenafil,vardenafilandtadalafil--reviewoftheliterature.EurJMedRes.2002Oct29.7(10):435-46.[2].OudotA,etal.CombinationofBAY60-4552andvardenafilexertsproerectilefacilitatoreffectsinratswithcavernousnerveinjury:aproofofconceptstudyforthetreatmentofphosphodiesterasetype5inhibitorfailure.EurUrol.2011Nov.60(5):1020-6.[3].AhmedN,etal.Hepatoprotectiveroleofvardenafilagainstexperimentallyinducedhepatitisinmice.JBiochemMolToxicol.2017Mar.31(3).[4].BódiB,etal.Long-TermPDE-5AInhibitionImprovesMyofilamentFunctioninLeftandRightVentricularCardiomyocytesthroughPartiallyDifferentMechanismsinDiabeticRatHearts.Antioxidants(Basel).2021Nov6.10(11):1776.[5].SaenzdeTejadaI,etal.ThephosphodiesteraseinhibitoryselectivityandtheinvitroandinvivopotencyofthenewPDE5inhibitorvardenafil.IntJImpotRes.2001;13(5):282-290.[6].AshourAE,etal.Vardenafildihydrochloride.ProfilesDrugSubstExcipRelatMethodol.2014;39:515-544.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.