ROS-inducer-4-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEROSinducer4Cat.No.:HY-159518分⼦式:C₄₉H₆₂BrO₄P分⼦量:825.89作⽤靶点:ReactiveOxygenSpecies;MitochondrialMetabolism;Apoptosis作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ROSinducer4(compoundTE3)⼀种线粒体抑制剂。ROSinducer4可导致肿瘤发⽣⼀系列与线粒体相关的⽣理变化，如线粒体碎裂、ROS的爆发性产⽣和积累、线粒体膜电位降低、ATP含量降低以及线粒体中ROS介导的凋亡信号的激活[1]。体外研究ROSinducer4(compoundTE3)showsanticanceractivityagainstHeLa,A549,andHCT-15cellswithIC50valuesof4.83,3.49,and8.74μM,respectively[1].ROSinducer4(8µM)disruptsmitochondrialfunctioninHeLacellsbyinducingROS[1].ROSinducer4(1-8µM)inducescellapoptosisinHeLacellsinadose-dependentmanner[1].ROSinducer4exhibitsgreatlyenhancedanticanceractivitycomparedtotheparentmoleculeErgosterolperoxide(HY-N3845)[1].体内研究TheLD50ofROSinducer4(compoundTE3)inC57BL/6femalemiceis70mg/kgandthe95%confidenceintervalwas59.29-97.9mg/kg[1].ROSinducer4(1-2mg/kg)hasbetteranti-cervicalcanceractivityandsafetythantheCisplatin(HY-17394),andcanactivatetheimmuneresponseinmice[1].ROSinducer4hasmoderatetoxicity,ROSinducer4doesnothavesignificanttoxiceffectsataneffectivedose(1mg/kg)[1].REFERENCES[1].LiuP,etal.Mitochondrialtargetedmodificationandanticancermechanismofnaturalproductergosterolperoxide.BioorgChem.2024Jul31;151:107688.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5