Rhynchophylline-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERhynchophylline(Standard)Cat.No.:HY-N0387RCASNo.:76-66-4分⼦式:C₂₂H₂₈N₂O₄分⼦量:384.47作⽤靶点:NF-κB作⽤通路:NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Rhynchophylline(Standard)Rhynchophylline的分析标准品。本产品⽤于研究及分析应⽤。钩藤碱(Rhyncholphylline)从钩藤中分离到的⼀种⽣物碱类化合物。钩藤碱⼀种EphA4抑制剂。钩藤碱具有很⾼的⽣物活性，被⼴泛⽤于抗炎、神经保护等⽅的研究。REFERENCES[1].DanYuan,etal.Anti-inflammatoryeffectsofrhynchophyllineandisorhynchophyllineinmouseN9microglialcellsandthemolecularmechanism.InternationalImmunopharmacologyVolume9,Issues13–14,December2009,Pages1549–1554[2].HoucaiHuang,etal.NeuroprotectiveEffectsofRhynchophyllineAgainstIschemicBrainInjuryviaRegulationoftheAkt/mTORandTLRsSignalingPathways.Molecules2014,19(8):11196-11210;doi:10.3390/molecules190811196[3].Tai-HyunKang,etal.Protectiveeffectofrhynchophyllineandisorhynchophyllineoninvitroischemia-inducedneuronaldamageinthehippocampus:putativeneurotransmitterreceptorsinvolvedintheiraction.LifeSciencesVolume76,Issue3,3December2004,Pages331–343[4].KinzoMatsumoto,etal.Suppressiveeffectsofisorhynchophyllineon5-HT2Areceptorfunctioninthebrain:Behaviouralandelectrophysiologicalstudies.EuropeanJournalofPharmacologyVolume517,Issue3,11July2005,Pages191–199[5].YangY,etal.RhynchophyllinesuppressessolubleAβ1-42-inducedimpairmentofspatialcognitionfunctionviainhibitingexcessiveactivationofextrasynapticNR2B-containingNMDAreceptors.Neuropharmacology.2018Jun;135:100-112.[6].FuAK,etal.BlockadeofEphA4signalingameliorateshippocampalsynapticdysfunctionsinmousemodelsofAlzheimer'sdisease.ProcNatlAcadSciUSA.2014Jul8;111(27):9959-64.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-