Norharmane-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENorharmane(Standard)Cat.No.:HY-W008566RCASNo.:244-63-3分⼦式:C₁₁H₈N₂分⼦量:168.2作⽤靶点:MonoamineOxidase;EndogenousMetabolite作⽤通路:NeuronalSignaling;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Norharmane(Standard)Norharmane的分析标准品。本产品⽤于研究及分析应⽤。Norharmane(Norharman)⼀种β-carboline⽣物碱，⼀种有效的可逆单胺氧化酶(monoamineoxidase)抑制剂，其对MAO-A和MAO-B的IC50分别为6.5and4.7μM。Norharmane引起抗抑郁反应。Norharmane还⼀种很有前景的抗癌光敏剂。Norharmane通过抑制PIN2、PIN3和PIN7转运蛋⽩来改变极性⽣长素转运，从⽽对拟南芥幼的⽣长产⽣显著的抑制作⽤。IC50&TargetIC50:4.7μM(MAO-B),6.5μM(MAO-A)[1]REFERENCES[1].HerraizT,etal.Humanmonoamineoxidaseenzymeinhibitionbycoffeeandbeta-carbolinesnorharmanandharmanisolatedfromcoffee.LifeSci.2006Jan18;78(8):795-802.[2].López-GonzálezD,etal.Anaturalindolealkaloid,norharmane,affectsPINexpressionpatternsandcompromisesrootgrowthinArabidopsisthaliana.PlantPhysiolBiochem.2020Jun;151:378-390.[3].Ebrahimi-GhiriM,etal.AnxiolyticandantidepressanteffectsofACPAandharmalineco-treatment.BehavBrainRes.2019May17;364:296-302.[4].SaitoK,ChenCY,MasanaM,CrowleyJS,MarkeySP,HeyesMP.4-Chloro-3-hydroxyanthranilate,6-chlorotryptophanandnorharmaneattenuatequinolinicacidformationbyinterferon-gamma-stimulatedmonocytes(THP-1cells).BiochemJ.1993Apr1;291(Pt1)(Pt1):11-4.[5].PaulBK,etal.BindingofnorharmanewithRNArevealstwothermodynamicallydifferentbindingmodeswithopposingheatcapacitychanges.JColloidInterfaceSci.2019Mar7;538:587-596.[6].LuoHZ,etal.InhibitoryeffectofnorharmaneonSerratiamarcescensNJ01quorumsensing-mediatedvirulencefactorsandbiofilmformation.Biofouling.2021Feb;37(2):145-160.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-