Methacholine-chloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMethacholinechloride(Standard)Cat.No.:HY-A0083RCASNo.:62-51-1分⼦式:C₈H₁₈ClNO₂分⼦量:195.69作⽤靶点:mAChR作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Methacholine(chloride)(Standard)Methacholine(chloride)的分析标准品。本产品⽤于研究及分析应⽤。Methacholine(Acetyl-β-methylcholine)choride⼀种有效的毒蕈碱-3muscarinic-3(M3)激动剂。Methacholinechoride直接作⽤于平滑肌上的⼄酰胆碱受体，导致⽀⽓管收缩和⽓道变窄。Methacholinechoride对识别⽀⽓管⾼反应性(BHR)显⽰出⾼灵敏度。Methacholinechoride可⽤于测量⽓道⾼反应性(AHR)，作为评估具有哮喘样症状和正常静息呼⽓流速的个体的诊断辅助[1][2][3][4]。REFERENCES[1].CohenJ,etal.RelationshipbetweenairwayresponsivenesstoneurokininAandmethacholineinasthma.PulmPharmacolTher.2005;18(3):171-176.[2].AndersonSD,etal.Comparisonofmannitolandmethacholinetopredictexercise-inducedbronchoconstrictionandaclinicaldiagnosisofasthma.RespirRes.2009;10(1):4.Published2009Jan23.[3].CockcroftDW.Methacholinechallengemethods.Chest.2008;134(4):678-680.[4].KabaraS,etal.Differentialeffectsofthiopentalonmethacholine-andserotonin-inducedbronchoconstrictionindogs.BrJAnaesth.2003Sep;91(3):379-84.[5].FolkertsG,etal.Bradykinincausesinhibitionofmethacholine-inducedbronchoconstrictioninvivoinmice.NaunynSchmiedebergsArchPharmacol.2001Jul;364(1):53-8.[6].VitorassoRL,etal.Methacholinedoseresponsecurveandacceptabilitycriteriaofrespiratorymechanicsmodeling.ExpLungRes.2020Feb-Mar;46(1-2):23-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589