课题组报告汇工作汇报

工作汇报汇报人：王铭铭工作汇总1，333系列2，二硫代氨基钠盐系列3，开链系列二硫代氨基钠盐系列评价挑菌（IMP10株，NDM-1选10株）化合物MIC筛选（单用联合用药，联合用药，MEM,NOTA,化合物10个）红细胞溶血（3个化合物）细胞毒（3个化合物）时间杀菌曲线锌离子联合用药酶活性实验蛋白分子对接开链系列挑菌（NDM共20株）化合物MIC筛选（单用联合用药，联合用药,MEM,NOTA,化合物3个）MIC菌株挑选菌株对应编号A1EC-13-22B1N5-15-2-1D1KP-13-9A2EC-13-33B2N5-15-2-2D2EC-13-26A3PM-13-36B3N5-15-2-24D3ECL-13-46A4CF-14-50B4N5-15-2-26D4ECL-14-57A5EC-15-3B5N5-15-2-35D5K-15-36A6KP-15-35B6N5-15-2-36D6EC-15-65A7PM-58B7N7-15-50D7KP-15-72A8PM-153B8N5-15-2-52D815-2-84A9KP-113B9N4-14-55D915-2-85A10KP-131B10N5-15-2-62D1015-2-88二硫代氨基钠盐联合用药MIC结果化合物编号/64kp-13-9EC-13-26ECL-13-46ECL-14-57K-15-36EC-15-65KP-15-7215-2-8415-2-8515-2-8849＜0.03125＜0.0312516＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125＜0.031251650＜0.03125＜0.031250.125＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125165182＞16884161681610384＞1681681616816137＞16＞16＞16＞16＞16＞16＞16＞16＞16＞161400.250.0625＜0.031250.06250.1250.0625＜0.03125＜0.031252＞16142162＞1616＞1616＞168＞16＞1614320.54＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125416146168＞168168161684147＜0.0312518812＜0.03125442化合物编号/32kp-13-9EC-13-26ECL-13-46ECL-14-57K-15-36EC-15-65KP-15-7215-2-8415-2-8515-2-884940.5＞16822＞1688165020.5＞16842888＞1651164＞1616168168816103164＞1681681616168137＞16＞16＞16＞16＞16＞16＞16＞16＞16＞16140＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125＜0.031250.0625＜0.03125＜0.03125＜0.0312514281＞168881688814340.5＞16882＜0.03125881614684＞16888168881478416888＜0.03125884化合物编号/64EC-13-22EC-13-33PM-13-36CF-14-50EC-15-3KP-15-35PM-58PM-153KP-113KP-13149＜0.03125＜0.03125＜0.03125＜0.031250.25＜0.03125416＜0.03125＜0.0312550＜0.03125＜0.03125＜0.03125＜0.031252＜0.03125280.25＜0.031255188162＞168161641610316842＞16448416137＞16＞16＞16＞16＞16＞16＞16＞16＞16＞16140＞16＞16＞16＞16＞16＞16＞16＞16＞16＞1614216＞16＞16＞16＞16＞160.25＞16＞16＞16143210.5＜0.0312516142＜0.031252146＞16888＞16881681614784241614218MEM单用20201010802020401020开链化合物联合用药MIC结果A系列菌株化合物固定浓度64μg/Ml化合物固定浓度64μg/Ml化合物编号187198199187198199A1222222A20.1250.1250.1250.1250.1250.125A30.50.50.50.50.51A40.1250.1250.1250.1250.1250.125A5121121A6222222A7444444A8442442A9222222A10222222D系列菌株化合物固定浓度64μg/Ml化合物固定浓度64μg/Ml化合物编号187198199187198199D1444444D2222222D3222222D40.50.50.50.50.50.5D50.125120.062512D60.250.250.250.1250.1250.125D7110.5111D80.1250.1250.1250.1250.250.125D9212211D100.12510.1250.062510.0625B系列菌株化合物固定浓度64μg/Ml化合物编号187198199B10.1250.1250.25B20.1250.06250.125B30.1250.06250.0625B40.1250.1250.125B50.1250.06250.0625B60.06250.06250.0625B70.1250.06