GSK-3β-inhibitor-17-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEGSK-3βinhibitor17Cat.No.:HY-163748CASNo.:2521624-67-7分子式:C₂₆H₁₈F₃N₅O₆S₂分子量:617.58作用靶点:GSK-3作用通路:PI3K/Akt/mTOR;StemCell/Wnt储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性GSK-3βinhibitor17(compound5n)是一种有效的GSK-3β抑制剂。GSK-3βinhibitor17可降低顺铂(HY-17394)诱导的p-p65、KIM-1蛋白和mRNA表达。GSK-3βinhibitor17可降低顺铂诱导的TNF-α、IL-1β、IL-6和MCP-1mRNA表达。GSK-3βinhibitor17具有抗炎作用，具有研究急性肾损伤的潜力[1]。IC50&TargetGSK-3β体外研究GSK-3βinhibitor17(compound5n)(16,32,64µM)reducescisplatin(HY-17394)inducedp-p65,KIM-1proteinexpressioninadose-dependentmanner[1].GSK-3βinhibitor17(32µM)decreasestheTNF-α,IL-1β,IL-6andMCP-1mRNAexpressionlevelsincisplatininducesacutekidneyinjury(AKI)inHK-2cells[1].WesternBlotAnalysis[1]CellLine:HK-2cellsConcentration:16,32,64µMIncubationTime:Result:Decreasedthecisplatin(20µM;24h)inducedproteinexpressionofp-p65,KIM-1.体内研究GSK-3βinhibitor17(12.5,25,50mg/kg;i.p.)reducescisplatin(HY-17394)inducedNF-κBsignalingactivationandinflammatorycytokinerelease,therebyreducingkidneyinjury[1].1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEAnimalModel:6-8weeks,20-22g,MaleC57/BL6mice(cisplatin20mg/kgi.p.for3days)[1]Dosage:12.5,25,50mg/kgAdministration:I.p.;24hbeforethemodelingResult:Inhibitedcisplatin-inducedrenalglycogenaccumulationandtubularnecrosis,5nsignificantlyreducedtheproteinlevelofp-P65incisplatintreatment,significantlydownregulatedmRNAlevelsofTNF-α,IL-1β,IL-6andMCP-1.REFERENCES[1].CaiYT,etal.AnovelGSK3βinhibitor5nattenuatesacutekidneyinjury.Heliyon.2024Apr12;10(8):e29159.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37