Digitoxin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDigitoxin(Standard)Cat.No.:HY-B1357RCASNo.:71-63-6分⼦式:C₄₁H₆₄O₁₃分⼦量:764.94作⽤靶点:Bcl-2Family;Caspase;Apoptosis;HSV;Na+/K+ATPase;CalciumChannel作⽤通路:Apoptosis;Anti-infection;MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Digitoxin(Standard)Digitoxin的分析标准品。本产品⽤于研究及分析应⽤。Digitoxin⼀种抗癌剂。Digitoxin可诱导细胞凋亡(apoptosis)、抑制流感细胞因⼦风、引起DNA双链断裂(DSBs)、将细胞周期阻滞在G2/M期。Digitoxin通过形成跨膜钙通道诱导细胞内钙摄取，可⽤于⼼⼒衰竭的研究[1][2][3][4][5]。REFERENCES[1].HauxJ.Digitoxinisapotentialanticanceragentforseveraltypesofcancer[J].Medicalhypotheses,1999,53(6):543-548.[2].SuCT,HsuJTA,HsiehHP,etal.Anti-HSVactivityofdigitoxinanditspossiblemechanisms[J].Antiviralresearch,2008,79(1):62-70.[3].GanH,QiM,ChanC,etal.DigitoxininhibitsHeLacellgrowththroughtheinductionofG2/Mcellcyclearrestandapoptosisinvitroandinvivo[J].InternationalJournalofOncology,2020,57(2):562-573.[4].PollardBS,BlancoJC,PollardJR.Classicaldrugdigitoxininhibitsinfluenzacytokinestorm,withimplicationsforCOVID-19therapy[J].invivo,2020,34(6):3723-3730.[5].ArispeN,etal.Heartfailuredrugdigitoxininducescalciumuptakeintocellsbyformingtransmembranecalciumchannels[J].ProceedingsoftheNationalAcademyofSciences,2008,105(7):2610-2615.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>