Avadomide-hydrochloride-CC-122-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAvadomidehydrochlorideCat.No.:HY-100507ACASNo.:1398053-45-6Synonyms:CC122hydrochloride分⼦式:C₁₄H₁₅ClN₄O₃分⼦量:322.75作⽤靶点:E1/E2/E3Enzyme;Apoptosis;MolecularGlues;NF-κB作⽤通路:MetabolicEnzyme/Protease;Apoptosis;PROTAC;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Avadomidehydrochloride(CC122hydrochloride)Avadomide(HY-100507)的盐酸盐形式。Avadomidehydrochloride⼝服有效的cereblon调节剂。Avadomidehydrochloride可以调节cereblonE3连接酶活性，抑制NF-κB通路，在G1期阻滞细胞周期，从⽽诱导癌细胞PDAC的细胞凋亡(apoptosis)。Avadomidehydrochloride具有抗肿瘤和免疫调节活性。户使⽤本产品发表的科研⽂献•NatCommun.2020Jul14;11(1):3508.•CellRepMed.2024Mar19;5(3):101472.•CellChemBiol.2020Jul16;27(7):866-876.e8.•iScience.2023Jun7;26(7):107059.•iScience.2023Jun1.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].RascoDW,etal.AFirst-in-HumanStudyofNovelCereblonModulatorAvadomide(CC-122)inAdvancedMalignancies.ClinCancerRes.2019Jan1;25(1):90-98.[2].Hagner,P.R.etal.CC-122,apleiotropicpathwaymodifier,mimicsanIFNresponseandhasantitumoractivityinDLBCL.Blood.Aug6;126(6):779-89.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[3].NishiH,etal.,Anti-tumoreffectofavadomideingemcitabine-resistantpancreaticductaladenocarcinoma.CancerChemotherPharmacol.2023Oct;92(4):303-314.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>