先睹为快！2024 AACR年会：PCF空间单细胞蛋白组应用案例集锦

先睹为快！2024AACR年会：PCF空间单细胞蛋白组应用案例集锦2024年美国癌症研究协会（AACR）年会于美国时间4月5日-10日在美国加州圣地亚哥举行。Cancerresearch杂志发表了年会提交的摘要，我们从中检索了新一代空间组学技术Phenocycler-Fusion（PCF）空间单细胞蛋白组技术的应用案例。从检索结果可以发现PCF空间单细胞蛋白组技术已经被广泛的应用到多种类型的肿瘤研究中，并且通过联合其他空间组学研究人员深度解析了肿瘤微环境的异质性和对不同治疗策略响应的空间机制。我们整理了部分PCF空间单细胞蛋白组的应用案例，希望能为国内研究人员提供一定的信息参考。题目：Deepspatialimmunophenotypingoflymphoidaggregatesinpancreaticcancerusingmulti-omicintegrationofultrahigh-plexproteomicsandtranscriptomics研究机构：MDAndersonCancerCenter类型：胰腺癌PCF抗体数量：96-plex其他平台：CosMxSMI链接：/cancerres/article/84/6_Supplement/3988/740632/Abstract-3988-Deep-spatial-immunophenotyping-of?searchresult=1题目：Multi-omicspatialanalysisofthetumormicroenvironmentingliomas研究机构：ThePrestonRobertTischBrainTumorCenteratDuke类型：神经胶质瘤PCF抗体数量：>50-plex其他平台：Xenium链接：/cancerres/article/84/6_Supplement/5496/741788/Abstract-5496-Multi-omic-spatial-analysis-of-the?searchresult=1题目：Spatialprofilingofpediatricrhabdomyosarcomatoelucidatetheirimmunosuppressivetumormicroenvironment研究机构：UniversityofQueensland类型：儿童横纹肌肉瘤PCF抗体数量：51-plex其他平台：GeoMxDSP链接：/cancerres/article/84/6_Supplement/73/737520/Abstract-73-Spatial-profiling-of-pediatric?searchresult=1题目：Dissectingtumor-immuneinteractioninresponseandresistancetoimmunecheckpointblockadeinmetastaticmelanoma研究机构：Dana-FarberCancerInstitute类型：黑色素瘤PCF抗体数量：NA其他平台：MERFISH链接：/cancerres/article/84/6_Supplement/2486/740207/Abstract-2486-Dissecting-tumor-immune-interaction?searchresult=1题目：Decipheringtherolesofgermlinepredispositionvariantsandsomaticmutationsonbreastcancercellsandthetumormicroenvironment研究机构：WashingtonUniversityinSt.Louis类型：乳腺癌PCF抗体数量：NA其他平台：sc/snRNA-seq、snATAC-seq链接：/cancerres/article/84/6_Supplement/1773/735532/Abstract-1773-Deciphering-the-roles-of-germline?searchresult=1题目：Spatial-resolvedsingle-cellanalysisofthetumormicroenvironmentinAlaskaNativecolorectalcancerpatients研究机构：FredHutchinsonCancerCenter类型：结直肠癌PCF抗体数量：40-plex链接：/cancerres/article/84/6_Supplement/3423/735764/Abstract-3423-Spatial-resolved-single-cell?searchresult=1题目：SpatiallyresolvedcellprofilingunveilstumormetabolicstatesassociatedwithimmunotherapyresponseinNSCLC研究机构：UniversityofQueensland类型：非小细胞肺癌PCF抗体数量：45-plex链接：/cancerres/article/84/6_Supplement/1158/737448/Abstract-1158-Spatially-resolved-cell-profiling?searchresult=1题目：Single-cellspatiallandscapeofthemutation-specifichumanlungtumorimmunemicroenvironment研究机构：JustusLiebigUniversity类型：肺癌PCF抗体数量：42-plex链接：/cancerres/article/84/6_Supplement/5508/738387/Abstract-5508-Single-cell-spatial-landscape-of-the?searchresult=1题目：High-resolutionspatialatlasrevealsinsightintospatiallandscapeoflungcancerandchroniclungdiseases研究机构：JustusLiebigUniversity类型：肺癌PCF抗体数量：45-plex链接：/cancerres/article/84/6_Supplement/5507/738388/Abstract-5507-High-resolution-spatial-atlas?searchresult=1题目：Comparativespatialanalysesofthetumorimmunelandscapeindifferentmousemodelsofglioblastoma研究机构：TheUniversityofMelbourne类型：胶质母细胞瘤（小鼠）PCF抗体数量：>40-plex链接：/cancerres/article/84/6_Supplement/3763/738464/Abstract-3763-Comparative-spatial-analyses-of-the?searchresult=1题目：Aspatio-temporalapproachtomappingthedynamicsofcutaneoussquamouscellcarcinomaprogressionandimmunotherapyresponse:AjourneythroughTiME研究机构：UniversityofQueensland类型：皮肤鳞状细胞癌PCF抗体数量：>50-plex链接：/cancerres/article/84/6_Supplement/6872/738111/Abstract-6872-A-spatio-temporal-approach-to?searchresult=1题目：Overlappinganddistinctmechanismsofeffectiveneoantigencancervaccinesandimmunecheckpointtherapy研究机构：MDAndersonCancerCenter类型：黑色素瘤（小鼠）PCF抗体数量：46-plex链接：/cancerres/article/84/6_Supplement/6738/736385/Abstract-6738-Overlapping-and-distinct-mechanisms?searchresult=1题目：Evolutionofthespatialmyeloid-lymphoidengagementinglioblastomaundertemozolomidetreatment研究机构：MDAndersonCancerCenter类型：胶质母细胞瘤PCF抗体数量：NA链接：/cancerres/article/84/6_Supplement/6171/736478/Abstract-6171-Evolution-of-the-spatial-myeloid?searchresult=1PhenoCycler-Fusion单细胞原位空间蛋白组学优势华盈生物PhenoCycler-Fusion单细胞原位空间蛋白组学技术资格证书华盈生物是美国AkoyaBioscience公司的PhenoCycler-Fusion空间单细胞蛋白组学技术认证服务商，已经被纳入了该技术的全球CRO服务提供者体系。借助全球领先的PhenoCycler-Fusion空间单细胞蛋白组学技术平台的建立，华盈生物将为中国客户提供更具精准医学特色的服务与合作，推动中国团队在空间生物学领域的研究水平，加快构建符合中国人群的精准医学模式。相关阅读单细胞测序之后再怎么做？这篇文章告诉你答案Immunity(IF=32.4)|空间多组学联合揭示免疫检查点联合疗法响应机制真实数据！一张切片实现101种蛋白的超多重空间单细胞原位成像4）炎症性肠病开启新的研究模式：从单细胞到空间原位分析5）CancerResearc